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4331-4340 of 14737 results in All results

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

  • 1st Edition
  • Volume 3
  • March 28, 2018
  • Benjamin Bonavida + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 1 6 4 3 2 - 7
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 3 7 5 4 - 3
Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy.

Brugada Phenocopy

  • 1st Edition
  • March 27, 2018
  • Adrian Baranchuk
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 1 1 5 1 - 2
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 1 1 5 2 - 9
Brugada Phenocopy: The Art of Recognizing the Brugada ECG Pattern details all aspects associated with alternative diagnosis to Brugada Syndrome (BrS). Coverage includes how to identify the proper ECG pattern, what to do to investigate for BrP, and how to avoid misinterpretations and the use of unnecessary and expensive treatments. Chapters are written by experienced professionals, many of whom are colleagues that initially described this condition. This easy to use volume is a must have reference for researchers of cardiology, cardiologists, electrocardiologists, internists, emergency care doctors and students, residents and fellows.

Surgery in Rheumatic and Musculoskeletal Disease

  • 1st Edition
  • Volume 15
  • March 26, 2018
  • Fabiola Atzeni + 4 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 6 3 8 8 7 - 8
  • eBook
    9 7 8 - 0 - 4 4 4 - 6 3 8 8 8 - 5
Surgery in Systemic Autoimmune Disease, Volume 15, describes the state-of-the-art of the use of surgery in treating the most common systemic autoimmune diseases (SADS). The volume consists of an introductory chapter concerning the impact of surgery on SADs, follow by eight chapters describing the use of surgery in the treatment of specific diseases in various areas (cardiology, gastroenterology, orthopedics, neurology. etc.) and the possible difficulties and complications. The final five chapters deal with the possible complications arising during the course of biological and non-biological treatment, also providing recommendation concerning their management. International in scope, the list of more than 20 contributors from Europa and America reads like a who’s who of clinical researchers in the field.

Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A

  • 1st Edition
  • Volume 602
  • March 24, 2018
  • Roderic Eckenhoff + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 1 2 7 4 0 - 7
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 2 7 4 1 - 4
Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A, Volume 602 assembles new information on our understanding of anesthesia. This latest release in the series includes sections on how physical accuracy leads to biological relevance, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, pharmacophore QSAR, QM, ONIOM, and kinetic modeling of electrophysiology data.

Plant Micronutrient Use Efficiency

  • 1st Edition
  • March 23, 2018
  • Mohammad Anwar Hossain + 4 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 2 1 0 4 - 7
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 2 2 4 3 - 3
Plant Micronutrient Use Efficiency: Molecular and Genomic Perspectives in Crop Plants presents information on the complex mechanisms regulating micronutrient use efficiency in plants. Understanding this science is essential for the development of new varieties of crop plants that are more resilient to micronutrient stress, as well as plants with increased bioavailable concentrations of essential micronutrients. This book explores the discovery of novel genes and key metabolic pathways associated with micronutrient use efficiency in plants, gives an analyses of the gene expression patterns in plants in response to low and/or high nutrient levels, and investigates the potential functions of these genes and their products. Strategies to enhance micronutrient use efficiency and stress tolerance, to develop bio-fortified crop, and to improve the sustainable utilization of natural resources are critically evaluated. The book contains both fundamental and advanced information as well as critical commentaries that are useful for those involved in the various fields that make up the plant sciences.

Biodiversity and Evolution

  • 1st Edition
  • March 23, 2018
  • Philippe Grandcolas + 1 more
  • English
  • Hardback
    9 7 8 - 1 - 7 8 5 4 8 - 2 7 7 - 9
  • eBook
    9 7 8 - 0 - 0 8 - 1 0 2 5 6 7 - 3
Biodiversity and Evolution includes chapters devoted to the evolution and biodiversity of organisms at the molecular level, based on the study of natural collections from the Museum of Natural History. The book starts with an epistemological and historical introduction and ends with a critical overview of the Anthropocene epoch.

Ischemic and Traumatic Brain and Spinal Cord Injuries

  • 1st Edition
  • March 21, 2018
  • Akhlaq A. Farooqui
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 3 5 9 6 - 9
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 3 5 9 7 - 6
Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting-edge information on molecular mechanisms, including the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. The book also covers the molecular mechanisms of drugs used for the treatment of neurotraumatic disease. Chapters are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy. The book integrates and consolidates knowledge on neurotraumatic diseases, with the hope of bringing forth more dramatic advances and developments, not only on molecular mechanisms, but also on the causes of, and treatments for, neurotraumatic diseases.

Food Processing for Increased Quality and Consumption

  • 1st Edition
  • Volume 18
  • March 20, 2018
  • Alexandru Mihai Grumezescu + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 1 4 4 7 - 6
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 1 4 9 9 - 5
Food Processing for Increased Quality and Consumption, Volume 18 in the Handbook of Food Bioengineering series, offers an updated perspective on the novel technologies utilized in food processing. This resource highlights their impact on health, industry and food bioengineering, also emphasizing the newest aspects of investigated technologies and specific food products through recently developed processing methods. As processed foods are more frequently consumed, there is increased demand to produce foods that attract people based on individual preferences, such as taste, texture or nutritional value. This book provides advantageous tools that improve food quality, preservation and aesthetics.

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology

  • 1st Edition
  • March 20, 2018
  • Salvatore V. Pizzo
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 2 3 5 1 - 5
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 2 3 5 2 - 2
Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78.

Lipid Modification by Enzymes and Engineered Microbes

  • 1st Edition
  • March 20, 2018
  • Uwe T. Bornscheuer
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 3 1 6 7 - 1
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 3 1 6 8 - 8
Lipid Modification by Enzymes and Engineered Microbes covers the state-of-the art use of enzymes as natural biocatalysts to modify oils, also presenting how microorganisms, such as yeast, can be designed. In the past ten years, the field has made enormous progress, not only with respect to the tools developed for the development of designer enzymes, but also in the metabolic engineering of microbes, the discovery of novel enzyme activities, and in reaction engineering/process development. For the first time, these advances are covered in a single-volume that is edited by leading enzymatic scientist Uwe Borchscheuer and authored by an international team of experts.

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