BioDesign Research

BioDesign Research is dedicated to information exchange in the interdisciplinary field of biosystems design. Its unique mission is to pave the way towards the predictable de novo design and assessment of engineered or reengineered living organisms using rational or automated methods to address global challenges in health, agriculture, and the environment.

The journal publishes high quality breakthrough research, reviews, editorials, and perspectives focusing on in silico biosystems design, genetic or epigenetic modification, and genome writing or rewriting in any organism. Topics include but are not limited to:
• Genome writing and rewriting (gene and genome editing, synthetic viral and cellular genomes).
• Biological engineering at the level of chemical (e.g., unnatural nucleotides and amino acids), molecule (e.g., protein and RNA), pathway (e.g., metabolic, signaling and immunological pathways), tissue, organ (e.g., organoids), and organism (e.g., microbiome, plants, and animals).
• Methods/tools for biodesign (e.g., pathway/whole-cell/whole-organism modelling, machine-learning, automated design, and bioengineering using algorithm-directed in vivo evolution).
• Biodesign theory (e.g., control theory).
• Biodesign applications (e.g., gene therapy, cancer research, pharmaceuticals, biomaterials, biosensing, diagnostics, bioremediation, biofuels, carbon sequestration, crop domestication and breeding, biological computation, gene circuits, and minimal organisms).