Biochimica et Biophysica Acta: General Subjects

BBA General Subjects invites submissions of original research, hypothesis-driven studies, and reviews that address topics in biochemistry and biophysics. Manuscripts should present significant advancements in our understanding of molecular mechanisms and be of broad scientific interest to a wide audience. Interdisciplinary studies are encouraged. Descriptive studies without biochemical or biophysical mechanistic evidence and insights are discouraged.

Preferred topics are

• Biomedicine: Fundamental and emerging topics in biochemistry/biophysics with potential medical implications

• Nanobiology/Nanotechnology: Nanoparticles, nanotoxicology, nanomedicine; the topics are not limited to formulation of nanoparticles but investigate mechanism of action on cell types or animal models.

• Omics: Genomics, proteomics, lipidomics, glycomics, bioinformatics experimentally addressing a defined biological question; descriptive bioinformatics studies that rely solely on publicly available data without experimental validation are discouraged.

• Chemical biology: Chemical compounds, drug mechanisms, synthesis of novel compounds, click chemistry

• Structural biology: Crystallography, NMR, multimeric proteins, protein dynamics, nucleic acids

• Novel complexes: Nucleic acids, pure natural compounds, synthetic compounds, protein complexes, nucleic acid derivatives

• Cellular signaling: Receptor signaling, protein phosphorylation cascades, phosphatases, secondary messengers, transcription regulation, gene expression

• Glycobiology: Sugar metabolites and metabolism, glycosylated proteins, membrane protein, glycosylation, glycomics

• Microbiology: Fundamental and applied microbiology, emphasizing biochemical and biophysical aspects and mechanistic insights into infection and disease, as well as the mechanism of action of antimicrobials; manuscripts on clinical aspects such as treatment outcomes, clinical trials, and patient management are not suitable for this journal.

• Redox biology: Redox switches, glutathione and thioredoxin systems, oxygen and nitrogen radical species, superoxide, hydrogen peroxide, hydroxyl radical, nitric oxide, peroxides, hypoxia, redox regulation of transcription factors

• Neurobiology: Neuronal growth factors and nerve signaling, glial cells, autonomic and central nervous systems

• Stem cells: Differentiation, stem cell isolation and cultivation, growth factors

• Advanced molecular imaging technologies: This may include both biochemical and biophysical approaches.

• Plant biology: Specific emphasis on molecular plant sciences with mechanistic details and their applications through plant biotechnology

• Mechanistic characterization of compounds having biochemical importance and general interest (drug leads, toxicants, nutrients, and metabolites)

BBA General Subjects does not consider studies on the biological effects of crude extracts of natural sources, natural extracts, or traditional medicine unless the exact active molecules are identified and singularly characterized and their mechanism of action is experimentally evaluated.