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Zika Virus Biology, Transmission, and Pathways: The Neuroscience of Zika, Volume One provides a detailed introduction to the molecular biology of the Zika virus and its features,… Read more
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Zika Virus Biology, Transmission, and Pathways: The Neuroscience of Zika, Volume One provides a detailed introduction to the molecular biology of the Zika virus and its features, transmission, and impact on neurological systems. Designed to better readers’ understanding of the Zika virus, this volume features chapters on the immune response, molecular mechanisms, and other areas to better understand underlying pathways. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions.
Section A – Zika Virus: Introductory chapters1. Flaviviruses and where the Zika virus fits in: An overviewAdrián Diaz2. The innate immune response during Zika virus infectionManuela Sales Lima Nascimento, Wilo Victor dos Santos, Amanda Costa Ayres Salmeron, Josélio Maria Galvão de Araújo, José Veríssimo Fernandes, and Paulo Marcos Matta Guedes3. The public health perspective of Zika virus infectionSaurabh RamBihariLal Shrivastava and Prateek Saurabh Shrivastava4. Inequality in Zika virus and congenital Zika syndromeFinn Diderichsen and Lia Giraldo da Silva Augusto5. Lifestyle factors and congenital Zika syndrome: Drugs, alcohol, and beyondDaniela Pires Ferreira Vivacqua and Cristina Barroso Hofer6. Economic impact of Zika virus infection and associated conditionsHenry Maia Peixoto, Luciana Guerra Gallo, Gilmara Lima Nascimento, and Maria Regina Fernandes de Oliveira7. Health promotion, health education, and risk communication for Zika virus diseaseErnesto R. Gregorio Jr and Jun Kobayashi8. Molecular mechanisms of Zika virus-induced neurological pathologyTrisha R. Barnard, Quinn H. Abram, and Selena M. Sagan9. Validation of Zika virus infections: Nonmolecular aspects, immunoassays, and beyondAnne J. Jääskeläinen10. Validation of Zika virus infections: A focus on molecular methodsAnne J. Jääskeläinen11. Coinfection of Zika with Dengue and Chikungunya virusMarlen Yelitza Carrillo-Hernández, Julian Ruiz-Saenz, and Marlen Martínez-Gutiérrez12. Zika virus, pathology, and control: Zika vaccine strategies in developmentGilles Gadea, Wildriss Viranaicken, and Philippe Desprès
Section B – Effects on neurological and body systems
13. The adult brain and neurologic manifestations of the Zika virusFernanda J.P. Marques and Osvaldo J.M. Nascimento14. Postmortem studies: Contribution to understand the pathogenesis of congenital Zika syndromeLeila Chimelli15. Developmental trajectories in infants and toddlers born with congenital Zika syndromeFernanda J.P. Marques, Osvaldo J.M. Nascimento, and Marcio Leyser16. Host genetic susceptibility to ZIKV congenital syndrome: A tale of twinsLuiz Carlos de Caires Junior, Ernesto Goulart, and Mayana Zatz17. Zika virus infection disrupts development of both neurons and glial cellsDan Xu and Zhiheng Xu18. Neurological manifestations similar to multiple sclerosis in adults after Zika virus infectionSoniza Vieira Alves-Leon, Fabrı´cia Lima Fontes-Dantas, and Fernanda Cristina Rueda-Lopes19. Zika virus and the blood-brain barrierRishya Manikam, Soe Hui Jen, Amni Adilah Ismail, Chandramathi Samudi Raju, and Shamala Devi Sekaran20. Systems immunology of flavivirus infectionViviane Schuch, Felipe Martins, Felipe Ten Caten, Mariana Araujo-Pereira, Marielton Dos Passos Cunha, Nadia El Khawanky, Otavio Cabral-Marques, and Helder I. Nakaya21. Genetic susceptibility to congenital Zika syndrome: Current research and future perspectivesÁtila Duque Rossi and Cynthia Chester Cardoso22. Hearing and Zika virus infectionMaria Helena de M. Barbosa, Maria Clara de Magalhães-Barbosa, and Arnaldo Prata-Barbosa23. Neuromyelitis optica spectrum disorder: What it is and how it relates to Zika virusMaíra Cardoso Aspahan and Paulo Pereira Christo24. Zika virus infection and cytokinesSimone G. Fonseca, Irmtraut Araci H. Pfrimer, Carla Judice, Fabio T.M. Costa, and Helder I. Nakaya25. Urological sequels in the scope of the Congenital Zika SyndromeLucia Maria Costa Monteiro26. Zika virus and impact on male fertilityJocelyne Piret and Guy Boivin27. Testicular cell types and infection by Zika virusLuwanika Mlera and Marshall E. Bloom28. Proteome alterations promoted by Zika virus infectionJuliana Miranda Tatara, Lucélia Santi, and Walter Orlando Beys-da-Silva29. SOMAscan proteomics of Zika-infected cellsKevin M. Coombs30. Zika virus as an oncolytic therapy against brain tumorsCarolini Kaid, Matt Sherwood, Thiago Mitsugi, and Mayana ZatzSection C – International aspects
31. Zika virus in BrazilAndrezza Nascimento, Alberto José da Silva Duarte, and Sabri Saeed Sanabani32. Zika virus and the Middle EastEyal Meltzer33. Genetic diversity of Zika virus in Thailand: How does this compare with other countriesAtchara Phumee and Padet Siriyasatien34. Zika virus in Vietnam: Biology, transmission, pathology, associated conditions, and controlsNguyen Thai Son, Ho Huu Tho, and Dinh-Toi Chu35. Zika virus in Vietnam: Epidemic, distribution, strain origin, and potential risks for community healthDinh-Toi Chu, Tiep Tien Nguyen, and Nguyen Thai Son36. Zika virus infection in Mexico: Epidemiological and clinical dataAlfonso Vallejos Parás, Concepción Grajales Muñiz, Teresita Rojas Mendoza, Lumumba Arriaga Nieto, and David Alejandro Cabrera GaytánSection D – Features of the virus and transmission
37. Cytopathicity and pathogenesis of Zika virus strainsSergio P. Alpuche-Lazcano and Anne Gatignol38. Molecular evolution and codon usage bias of Zika virusMarianoel Pereira-Gómez and Juan Cristina39. Endosomal compartmentation and the transport route of Zika virusKatarzyna Owczarek and Krzysztof Pyrć40. Location of virus antigens in murine tissues infected with Zika virusAntónio Pedro Alves de Matos, Libia Zé-Zé, Fátima Amaro, and Maria João Alves41. The role of seminal Zika viral shedding: Tropism, duration, and magnitudeErin M. McDonald and Aaron C. Brault42. Nonhuman occurrence of Zika virus infection: compare with other countries Cécile Beck, Rodolphe Hamel, Marine Dumarest, Gaelle Gonzalez, and Sylvie Lecollinet43. Zika virus intrusion into the blood supply: Concerns about transfusion safetyBruno Deltreggia Benites and Marcelo Addas-CarvalhoSection E – Resources44. Research and recommended resources on Zika virus, pathology, and controlRajkumar Rajendram, Victor R. Preedy, and Vinood B. Patel
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Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.
Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.
Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.
Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.