Volpe's Neurology of the Newborn

6th Edition - November 3, 2017
Authors: Joseph J. Volpe, Terrie E. Inder, Basil T. Darras, Linda S. de Vries, Adre J du Plessis, Jeffrey Neil, Jeffrey M Perlman
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 4 2 8 7 6 - 7

A clear, engaging writing style, hundreds of full-color images, and new information throughout make Volpe’s Neurology of the Newborn, 6th Edition, an indispensable resource for tho… Read more

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A clear, engaging writing style, hundreds of full-color images, and new information throughout make Volpe’s Neurology of the Newborn, 6th Edition, an indispensable resource for those who provide care for neonates with neurological conditions. World authority Dr. Joseph Volpe, along with Dr. Terrie E. Inder and other distinguished editors, continue the unparalleled clarity and guidance you’ve come to expect from the leading reference in the field – keeping you up to date with today’s latest advances in diagnosis and management, as well as the many scientific and technological advances that are revolutionizing neonatal neurology.

Cover image
Title Page
Table of Contents
Copyright
Dedication
Contributors
Preface to the Sixth Edition
Preface to the First Edition
Acknowledgments
Video Contents
Unit I Human Brain Development
1 Neural Tube Development
Abstract
Normal Development of the Fundamental Central Neuroaxis
Disorders of Craniospinal Development
References
2 Prosencephalic Development
Abstract
Normal Prosencephalic Development
Disorders of Prosencephalic Development
References
3 Congenital Hydrocephalus
Fetal Ventriculomegaly
Management of Congenital Hydrocephalus
References
4 Cerebellar Development
Abstract
Normal Development of the Posterior Fossa Structures
Abnormal Development of the Posterior Fossa Structures
Reference
5 Neuronal Proliferation
Abstract
Neuronal Proliferation
References
6 Neuronal Migration
Abstract
Migration
References
7 Organizational Events
Abstract
Normal Development
Disorders of Organizational Events
References
8 Myelination Events
Abstract
Normal Development
Disorders
References
Unit II Neurological Evaluation
9 Neurological Examination
Normal Neurological Examination
Abnormal Neurological Features
Value of the Neonatal Neurological Examination
References
10 Specialized Neurological Studies
Abstract
Cerebrospinal Fluid Examination
Neurophysiological Studies
References
11 Neurodevelopmental Follow-Up
Abstract
Principles and Concepts of Child Development
Which Infants Need Follow-Up?
Models of Neurodevelopmental Follow-Up
The Timing of Follow-Up Assessments
Duration of Follow-Up
Neurodevelopmental Domains to Assess
Child Characteristics
References
Unit III Neonatal Seizures
12 Neonatal Seizures
Abstract
Pathophysiology
Clinical Aspects
References
Unit IV Hypoxic-Ischemic and Related Disorders
13 Pathophysiology
Abstract
Definitions
Primary Mediators of Hypoxic-Ischemic Injury in the Newborn Brain—Physiological and Biochemical
Physiological Mediators: Cerebral Blood Flow
Biochemical Mediators of Hypoxic-Ischemic Cerebral Injury—Human Newborn and Relevant Experimental Models
References
14 Encephalopathy of Prematurity
Abstract
Neuropathological Features of the Encephalopathy of Prematurity
Encephalopathy of Prematurity—Neuropathology in Living Infants
References
15 Encephalopathy of Prematurity
Abstract
Overview of Pathogenesis
References
16 Encephalopathy of Prematurity
Abstract
Clinical Settings
NeurologicAL Syndrome
Diagnosis
Prognosis and Clinicopathological Correlations
Management
References
17 Intrauterine, Intrapartum Assessments in the Term Infant
Abstract
Antepartum Assessment
Intrapartum Assessment
References
18 Hypoxic-Ischemic Injury in the Term Infant
Abstract
Neuropathology
References
19 Hypoxic-Ischemic Injury in the Term Infant
Abstract
Selective Neuronal Necrosis
Parasagittal Cerebral Injury
Cerebral White Matter Injury/Periventricular Leukomalacia
References
20 Hypoxic-Ischemic Injury in the Term Infant
Abstract
Clinical Settings
Neurological Syndrome
Diagnosis
Clinicopathological Correlations
Prognosis
Management
References
21 Stroke in the Newborn
Abstract
Classification-Nomenclature
Perinatal Arterial Ischemic Stroke
Cerebral Sinovenous Thrombosis
References
Unit V Intracranial Hemorrhage
22 Intracranial Hemorrhage
Abstract
Overview
Subdural Hemorrhage
Primary Subarachnoid Hemorrhage
Intraventricular Hemorrhage of the Term Infant
Miscellaneous Examples of Neonatal Intracranial Hemorrhage
References
23 Cerebellar Hemorrhage
Abstract
Cerebellar Hemorrhage: Preterm Infants
Cerebellar Hemorrhage: Term Infant
References
24 Preterm Intraventricular Hemorrhage/Posthemorrhagic Hydrocephalus
Abstract
Neuropathology
Pathogenesis
Clinical Features
Diagnosis
Prognosis
Management
References
Unit VI Metabolic Encephalopathies
25 Glucose
Definition
Normal Metabolic Aspects
Biochemical Aspects of Hypoglycemia
Neuropathology
Clinical Aspects
References
26 Bilirubin
Normal Bilirubin Structure and Metabolism
Pathophysiology
Neuropathology
Clinical Aspects of Acute and Chronic Bilirubin Encephalopathies
References
27 Amino Acids
Abstract
Overview of Aminoacidopathies With Neonatal Neurological Manifestations
Maple Syrup Urine Disease
Nonketotic Hyperglycinemia (Glycine Encephalopathy)
Hyperammonemia
Acquired Disorders With Neonatal HYPERAMMONEMIA
Miscellaneous Amino Acid Disorders
References
28 Organic Acids
Overview of Major Organic Acid Disorders and Neonatal Metabolic Acidosis
Disorders of Propionate and Methylmalonate Metabolism
Disorders of Pyruvate and Mitochondrial Energy Metabolism
Disorders of Branched-Chain Ketoacid Metabolism
Disorders of Fatty Acid Oxidation
Other Organic Acid Disorders
References
Unit VII Degenerative Disorders
29 Degenerative Disorders of the Newborn
Abstract
Major Disorders
Disorders Primarily Affecting Gray Matter
Disorders Primarily Affecting White Matter
Disorders Affecting Both Gray and White Matter
References
Unit VIII Neuromuscular Disorders
30 Evaluation, Special Studies
Abstract
Motor System
Evaluation of Disorders of the Motor System
References
31 Arthrogryposis Multiplex Congenita
Clinical Features
Pathogenesis
Pathology
Diagnosis
Management
References
32 Levels Above Lower Motor Neuron to Neuromuscular Junction
Abstract
Levels Above the Lower Motor Neuron
Level of the Lower Motor Neuron
Level of the Peripheral Nerve
Level of the Neuromuscular Junction
References
33 Muscle Involvement and Restricted Disorders
Abstract
Level of the Muscle
Restricted Neuromuscular Disorders
Distinguishing Features of Disorders of the Motor System
References
Unit IX Intracranial Infections
34 Viral, Protozoan, and Related Intracranial Infections
Abstract
Destructive Versus Teratogenic Effects
TORCH Infections
Other Viruses
References
35 Bacterial and Fungal Intracranial Infections
Abstract
Bacterial Meningitis
Brain Abscess
Disseminated Fungal Infection
Tetanus Neonatorum
Acknowledgment
References
Unit X Perinatal Trauma
36 Injuries of Extracranial, Cranial, Intracranial, Spinal Cord, and Peripheral Nervous System Structures
Abstract
Major Varieties of Perinatal Trauma
Injury to Extracranial, Cranial, and Central Nervous System Structures
Injury to Peripheral Nervous System Structures
References
Unit XI Intracranial Mass Lesions
37 Brain Tumors and Vein of Galen Malformations
Abstract
Brain Tumors
Vein of Galen Malformation
Arachnoid Cysts
References
Unit XII Drugs and The Developing Nervous System
38 Passive Addiction and Teratogenic Effects
Abstract
Major Factors Involved in Neurologic Disturbances Associated With Intrauterine Drug Exposure
Developmental Consequences for the Infant
Alcohol
Antiepileptic Drugs
Stimulants
Opioids
Antidepressants
Sedatives
Anesthetics
Marijuana
Drug Use and the Preterm Infant
Conclusions
References
Index

Joseph J. Volpe

Joseph Volpe is generally considered to have founded the field of neonatal neurology.

Affiliations and expertise

Bronson Crothers Professor of Neurology, Emeritus, Harvard Medical School, Neurologist-in-Chief, Emeritus, Boston Children’s Hospital, Department of Pediatric Newborn Medicine, Harvard Institutes of Medicine, Boston, Massachusetts

Terrie E. Inder

Dr. Inder is a dual-boarded neonatologist and child neurologist and is the current Chair of the Department of Pediatric Newborn Medicine. A native of New Zealand, she previously worked at the University of Melbourne, and Washington University in St. Louis before joining Brigham and Women’s Hospital in 2013. She has a passion for improving long-term outcomes of high-risk infants including premature infants and at-risk term born infants. Dr. Inder is the Mary Ellen Avery Professor of Pediatrics in the Field of Newborn Medicine at Harvard Medical School.

Affiliations and expertise

Mary Ellen Avery Professor of Pediatrics, Harvard Medical School, Chair, Department of Pediatric, Newborn Medicine, Brigham and Women’s Hospital, Boston, Massachusetts

Basil T. Darras

Dr. Basil T. Darras is Associate Neurologist-in-Chief and Chief of the Division of Clinical Neurology at Boston Children’s Hospital, and the Joseph J. Volpe Professor of Neurology at Harvard Medical School. Dr. Darras is a pediatric neurologist with advanced training and certification in human genetics and neuromuscular medicine. At Boston Children’s he serves as Director of the Neuromuscular Program, which includes one of the oldest and most active muscular dystrophy clinics in the country and where he specializes in the care of children with neuromuscular conditions originating from inherited or acquired conditions of the motor unit. He has published over 140 original reports in peer-reviewed journals and over 70 chapters, reviews and editorials; his major publications and specific research interests have focused on the molecular genetics, diagnostics, and therapeutics of Duchenne and Becker muscular dystrophies and spinal muscular atrophy, and on defining the indications for new diagnostic methodologies in the evaluation of children with pediatric neuromuscular diseases. Basic research, carried out in collaboration with scientists in the research laboratories of Boston Children’s and other institutions, focuses on the description of novel mutations in patients with neuromuscular diseases and the application of new technologies to explore the pathogenesis and treatment of congenital myopathies and muscular dystrophies. Dr. Darras is site PI for the consortium conducting Pediatric Neuromuscular Clinical Research in Spinal Muscular Atrophy, and site PI/PD for the NeuroNEXT NINDS Program. He is currently involved in multiple clinical trials of novel genetic interventions for the treatment of spinal muscular atrophy and Duchenne muscular dystrophy.

Affiliations and expertise

Children's Hospital, Boston, MA, USA

Linda S. de Vries

Linda de Vries is a neonatologist and pediatric neurologist, and obtained her PhD degree in Utrecht (1987). Since 1989, she has worked in the department of Neonatology in the University Medical Center Utrecht, where she is a professor in Neonatal Neurology. Her research focuses on prediction of neurodevelopmental outcome in high risk preterm and full-term newborns, using neurophysiology and neuro-imaging methods. These at risk children are also seen by her in the follow-up clinic until early childhood. She has a special interest in neonatal stroke and brain plasticity. Her work has been published in >400 publications.

Affiliations and expertise

Professor of Neonatal Neurology, Department of Neonatology, UMC Utrecht, Utrecht, The Netherlands

Adre J du Plessis

Affiliations and expertise

The Fetal Medicine Institute, Children's National Health System, Washington, Distric of Columbia

Jeffrey Neil

Affiliations and expertise

Boston Children's Hospital, Department of Neurology, Boston, Massachusetts

Jeffrey M Perlman

Affiliations and expertise

Chief, Division of Newborn Medicine, Professor of Pediatrics, Weill Cornell Medical College, New York, New York