
Viscoelasticity and Collective Cell Migration
An Interdisciplinary Perspective Across Levels of Organization
- 1st Edition - January 13, 2021
- Imprint: Academic Press
- Editors: Ivana Pajic-Lijakovic, Elias Barriga
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 0 3 1 0 - 1
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 0 3 1 1 - 8
Viscoelasticity and Collective Cell Migration: An Interdisciplinary Perspective Across Levels of Organization focuses on the main viscoelastic parameters formulated based on multis… Read more

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Request a sales quoteViscoelasticity and Collective Cell Migration: An Interdisciplinary Perspective Across Levels of Organization focuses on the main viscoelastic parameters formulated based on multiscale constitutive modeling and how to measure these rheological parameters based on existent micro-devices such as micro-rheology and micro-elastography. The book sheds light on inter-relationships across viscoelasticity scales, an essential step for understanding various biomedical processes such as morphogenesis, wound healing and cancers invasion. Cumulative effects of structural changes at subcellular and cellular levels influence viscoelasticity at a supracellular level are also covered, providing valuable insights for biologists, physicists, engineers, students and researchers in the field of developmental biology.
As this is a complex multidisciplinary field, perspectives are included from experts in biology, biochemistry, biomedicine, biophysics and biorheology. Readers will gain a deeper understanding of the complex dynamics that represent challenges and the necessity for further development in the field.
- Discusses the biological/biochemical mechanisms of collective cell migration
- Covers the inter-relation between collective cell migration and viscoelasticity by proposing rheological parameters
- Contains critical consideration of various experimental techniques that are suitable to measure these parameters
Research Scientists/ Engineers and Graduate Students working in the field of Viscoelasticity
- Cover image
- Title page
- Table of Contents
- Copyright
- List of Contributors
- Chapter one. The basics of collective cell migration: unity makes strength
- Abstract
- 1.1 Introduction
- 1.2 Experimental models to study collective cell migration
- 1.3 Using cell–cell junctions to stay as a group and communicate
- 1.4 Future perspectives
- Acknowledgments
- References
- Chapter two. The basic concept of viscoelasticity
- Abstract
- 2.1 Introduction
- 2.2 Linear viscoelasticity: constitutive models
- 2.3 Characteristics of the jamming state as the nonlinear viscoelastic solid
- 2.4 The main characteristics of various viscoelastic models
- 2.5 Relaxation of multicellular systems under externally applied stress conditions
- 2.6 Conclusions
- Acknowledgment
- References
- Chapter three. Biophysical origins of viscoelasticity during collective cell migration
- Abstract
- 3.1 Introduction
- 3.2 Timescale-dependent behavior in viscoelastic materials
- 3.3 Measuring viscoelastic behavior in biology
- 3.4 Viscoelasticity of the actin cytoskeleton
- 3.5 Cell–substrate adhesions and force transmission during migration
- 3.6 Substrate mechanics during migration
- 3.7 Cell–cell adhesion dynamics
- 3.8 Viscoelasticity in collective tissue migration
- 3.9 Conclusion
- Acknowledgments
- References
- Chapter four. Fine-tuning viscoelasticity: the key to collectively move in vivo
- Abstract
- 4.1 Introduction
- 4.2 Viscoelasticity of cellular components
- 4.3 Sensing and transducing environmental viscoelasticity
- 4.4 Environmental viscoelasticity triggers and directs collective migration
- 4.5 Concluding remarks and future perspectives
- Acknowledgments
- References
- Chapter five. Effects of time delays and viscoelastic parameters in oscillatory response of cell monolayers
- Abstract
- 5.1 Introduction
- 5.2 Planar deformations
- 5.3 Analysis of tissue cross-section
- 5.4 Conclusions
- Acknowledgments
- References
- Chapter six. Viscoelastic properties driving collective migration in zebrafish development
- Abstract
- 6.1 Introduction
- 6.2 Morphogenesis and zebrafish development
- 6.3 Epiboly
- 6.4 Doming
- 6.5 Gastrulation
- 6.6 Somite formation
- 6.7 Outlook
- References
- Chapter seven. Oscillations in collective cell migration
- Abstract
- 7.1 Introduction
- 7.2 Mechanism of collective cell motion
- 7.3 Propagative waves
- 7.4 Standing waves in fully confined monolayers
- 7.5 Mechanical considerations
- 7.6 Discussion
- 7.7 Conclusion and perspective
- References
- Chapter eight. Flow dynamics of 3D multicellular systems into capillaries
- Abstract
- 8.1 Introduction
- 8.2 Micropipette aspiration technique: a practical guide
- 8.3 Viscoelastic behavior of cellular aggregates
- 8.4 Active response of cellular aggregates to mechanical stimuli
- 8.5 Permeability of cellular aggregates
- 8.6 Conclusions and perspectives
- Acknowledgments
- References
- Chapter nine. Viscoelasticity of multicellular systems caused by collective cell migration: multiscale modeling considerations
- Abstract
- 9.1 Introduction
- 9.2 Phenomenological description of long-time rearrangement of multicellular surfaces under external stress
- 9.3 Long-time viscoelasticity at a mesoscopic level—constitutive modeling
- 9.4 Long-time viscoelasticity at a macroscopic level—constitutive modeling
- 9.5 Conclusion
- Acknowledgment
- Declaration of interest
- Appendix 1
- Appendix 2
- References
- Chapter ten. Recent advances in imaging of cell elasticity
- Abstract
- 10.1 Introduction
- 10.2 Cell structure: key architectural players in elasticity
- 10.3 Estimation of cell elasticity
- 10.4 Rheological modeling of a single cell
- 10.5 Trends in viscoelastography
- 10.6 Summary
- Acknowledgment
- References
- Index
- Edition: 1
- Published: January 13, 2021
- Imprint: Academic Press
- No. of pages: 314
- Language: English
- Paperback ISBN: 9780128203101
- eBook ISBN: 9780128203118
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Ivana Pajic-Lijakovic
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