Vascular Smooth Muscle: Metabolic, Ionic, and Contractile Mechanisms

List of Contributors

Preface


1. Vascular Smooth Muscle: Relations between Energy Metabolism and Mechanics

I. Introduction

II. Relations between Metabolism and Contractility in Vascular Smooth Muscle

III. Relations between Metabolism and Contractility—Current Questions

IV. Mechanisms and Energetics of Contraction

V. Coordination of Metabolism and Contractility

VI. Applied Aspects of Smooth Muscle Mechanochemistry: Hypertension

VII. Summary and Perspectives

References


2. Electrolyte Metabolism of the Arterial Wall

I. Introduction

II. Electrolyte Distribution

III. Electrolyte Transport

IV. Metabolic Control

References


3. Membrane Electrical Activation of Arterial Smooth Muscle

I. Introduction

II. Membrane Potential (Em) of Arterial Smooth Muscle as a Function of External K+ ([K])o

III. K+ Conductance (gK) and Electrical Activity

IV. Importance of Em in Controlling the Active State of Arterial Smooth Muscle

V. Summary

References


4. Current Status of Vascular Smooth Muscle Subcellular Calcium Regulation

I. Introduction

II. Physiological Heterogeneity

III. Subcellular Calcium Regulation: Biochemical Approaches

IV. Cyclic Adenosine 3’,5'-Monophosphate and Calcium Regulation

V. Hypertension and Subcellular Calcium Regulation

VI. Summary and Conclusions

References


5. The Contractile Apparatus of Smooth Muscle and Its Regulation by Calcium

I. Introduction

II. Contractile Apparatus

III. Types of Regulatory Mechanisms

IV. Regulatory Mechanisms in Vertebrate Smooth Muscle

References


6. Lipid Transport and Atherogenesis: Role of Apolipoproteins

I. Introduction

II. Lipoprotein Composition

III. Lipoprotein Structure

IV. Apoprotein Structure, Metabolism, Function, and Role in Disease

V. Lipid Transport and Atherosclerosis

VI. Summary

References

Index