Vascular Pharmacology
Smooth Muscle
- 1st Edition, Volume 78 - February 13, 2017
- Editor: Raouf A Khalil
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 1 1 4 8 5 - 8
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 1 4 8 6 - 5
Vascular Pharmacology: Smooth Muscle provides up-to-date information on the structure, function, signaling, and development of vascular smooth muscle. Contributors include p… Read more
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Request a sales quoteVascular Pharmacology: Smooth Muscle provides up-to-date information on the structure, function, signaling, and development of vascular smooth muscle. Contributors include prominent scientists and highly-recognized experts with major accomplishments in the field of vascular smooth muscle research.
- Presents a must read reference on vascular smooth muscle physiology and pharmacology
- Contains up-to-date information on the structure, function, signaling, and development of vascular smooth muscle
- Includes contributors from prominent scientists and highly-recognized experts with major accomplishments in the field of vascular smooth muscle research
Chapter One: Nanojunctions of the Sarcoplasmic Reticulum Deliver Site- and Function-Specific Calcium Signaling in Vascular Smooth Muscles
- Abstract
- 1 Introduction
- 2 What Defines a Nanojunction?
- 3 Conclusion
- Conflict of Interest
- Acknowledgments
Chapter Two: Calcium Channels in Vascular Smooth Muscle
- Abstract
- 1 Introduction
- 2 Plasmalemmal Ca2 +-Permeable Channels
- 3 SR Ca2 + Channels
- 4 Mitochondrial Ca2 + Channels
- 5 Conclusion
- Conflict of Interest
- Acknowledgments
Chapter Three: Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth
- Abstract
- 1 Introduction
- 2 Potassium Channels and Regulation of VSM Contraction
- 3 K+ Channels and VSM Proliferation
- 4 Conclusion
- Conflict of Interest
- Acknowledgments
Chapter Four: Sodium–Calcium Exchanger in Pig Coronary Artery
- Abstract
- 1 Introduction
- 2 NCX in Coronary Artery Smooth Muscle
- 3 NCX in SMC
- 4 Functional Coupling of NCX and SER in SMC
- 5 Colocalization of NCX1 and SERCA2 in SMC
- 6 Effect of Thapsigargin on Colocalization of NCX1 and SERCA2 in SMC
- 7 Comparison of NCX in Coronary Artery SMC and EC
- 8 Conclusion
- Conflict of Interest
- Acknowledgments
Chapter Five: Ca2 +/Calmodulin-Dependent Protein Kinase II in Vascular Smooth Muscle
- Abstract
- 1 Introduction
- 2 CaMKII Structure and Expression in VSM
- 3 CaMKII Activation in VSM
- 4 CaMKII Function in VSM
- 5 Conclusion
- Conflict of Interest
Chapter Six: Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders
- Abstract
- 1 Introduction
- 2 PKC Structure and Isoforms
- 3 PKC Distribution and Translocation
- 4 PKC Phosphorylation
- 5 PKC Activators
- 6 PKC Substrates
- 7 PKC Inhibitors
- 8 Vascular Effects of PKC
- 9 Physiological Changes in PKC
- 10 PKC in Vascular Injury and Disease
- 11 Conclusion
- Conflict of Interest
- Acknowledgments
Chapter Seven: Rho-Mancing to Sensitize Calcium Signaling for Contraction in the Vasculature: Role of Rho Kinase
- Abstract
- 1 Introduction
- 2 RhoA/Rho Kinase Structure and Expression
- 3 Rho Kinase Function
- 4 Regulation of RhoA/Rho Kinase Activity via Posttranslational Modifications
- 5 RhoA/Rho Kinase-Mediated Ca2 + Sensitization in Vascular Disease and Rho Kinase Inhibitors: Focus on Hypertension
- 6 Conclusion
- Conflict of Interest
Chapter Eight: Vascular Cells in Blood Vessel Wall Development and Disease
- Abstract
- 1 Introduction
- 2 Blood Vessel Development
- 3 Cardiovascular Diseases
- 4 Conclusion
- Conflict of Interest
Chapter Nine: Notch Signaling in Vascular Smooth Muscle Cells
- Abstract
- 1 Introduction
- 2 The Notch Signaling Pathway
- 3 Notch Signaling in VSMC Development
- 4 Notch Signaling and VSMC Phenotype
- 5 Notch Signaling in Vascular Disease
- 6 Conclusion
- Conflict of Interests
- Acknowledgments
Chapter Ten: Smooth Muscle Phenotypic Diversity: Effect on Vascular Function and Drug Responses
- Abstract
- 1 Introduction
- 2 Brief Review of the Players in VSM Contractile Function
- 3 Diversity Within the Vascular System
- 4 Agonist-Mediated Vasoconstriction and Its Antagonism
- 5 Signaling-Mediated Vasodilation and Its Agonism
- 6 Calcium Flux and Its Inhibition
- 7 Diversity Within Human Populations
- 8 Conclusion
- Conflict of Interest
- Acknowledgment
- No. of pages: 428
- Language: English
- Edition: 1
- Volume: 78
- Published: February 13, 2017
- Imprint: Academic Press
- Hardback ISBN: 9780128114858
- eBook ISBN: 9780128114865
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