Vascular Pharmacology

Chapter One: Nanojunctions of the Sarcoplasmic Reticulum Deliver Site- and Function-Specific Calcium Signaling in Vascular Smooth Muscles

• Abstract
• 1 Introduction
• 2 What Defines a Nanojunction?
• 3 Conclusion
• Conflict of Interest
• Acknowledgments

Chapter Two: Calcium Channels in Vascular Smooth Muscle

• Abstract
• 1 Introduction
• 2 Plasmalemmal Ca^{2 +}-Permeable Channels
• 3 SR Ca^{2 +} Channels
• 4 Mitochondrial Ca^{2 +} Channels
• 5 Conclusion
• Conflict of Interest
• Acknowledgments

Chapter Three: Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth

• Abstract
• 1 Introduction
• 2 Potassium Channels and Regulation of VSM Contraction
• 3 K⁺ Channels and VSM Proliferation
• 4 Conclusion
• Conflict of Interest
• Acknowledgments

Chapter Four: Sodium–Calcium Exchanger in Pig Coronary Artery

• Abstract
• 1 Introduction
• 2 NCX in Coronary Artery Smooth Muscle
• 3 NCX in SMC
• 4 Functional Coupling of NCX and SER in SMC
• 5 Colocalization of NCX1 and SERCA2 in SMC
• 6 Effect of Thapsigargin on Colocalization of NCX1 and SERCA2 in SMC
• 7 Comparison of NCX in Coronary Artery SMC and EC
• 8 Conclusion
• Conflict of Interest
• Acknowledgments

Chapter Five: Ca^{2 +}/Calmodulin-Dependent Protein Kinase II in Vascular Smooth Muscle

• Abstract
• 1 Introduction
• 2 CaMKII Structure and Expression in VSM
• 3 CaMKII Activation in VSM
• 4 CaMKII Function in VSM
• 5 Conclusion
• Conflict of Interest

Chapter Six: Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders

• Abstract
• 1 Introduction
• 2 PKC Structure and Isoforms
• 3 PKC Distribution and Translocation
• 4 PKC Phosphorylation
• 5 PKC Activators
• 6 PKC Substrates
• 7 PKC Inhibitors
• 8 Vascular Effects of PKC
• 9 Physiological Changes in PKC
• 10 PKC in Vascular Injury and Disease
• 11 Conclusion
• Conflict of Interest
• Acknowledgments

Chapter Seven: Rho-Mancing to Sensitize Calcium Signaling for Contraction in the Vasculature: Role of Rho Kinase

• Abstract
• 1 Introduction
• 2 RhoA/Rho Kinase Structure and Expression
• 3 Rho Kinase Function
• 4 Regulation of RhoA/Rho Kinase Activity via Posttranslational Modifications
• 5 RhoA/Rho Kinase-Mediated Ca^{2 +} Sensitization in Vascular Disease and Rho Kinase Inhibitors: Focus on Hypertension
• 6 Conclusion
• Conflict of Interest

Chapter Eight: Vascular Cells in Blood Vessel Wall Development and Disease

• Abstract
• 1 Introduction
• 2 Blood Vessel Development
• 3 Cardiovascular Diseases
• 4 Conclusion
• Conflict of Interest

Chapter Nine: Notch Signaling in Vascular Smooth Muscle Cells

• Abstract
• 1 Introduction
• 2 The Notch Signaling Pathway
• 3 Notch Signaling in VSMC Development
• 4 Notch Signaling and VSMC Phenotype
• 5 Notch Signaling in Vascular Disease
• 6 Conclusion
• Conflict of Interests
• Acknowledgments

Chapter Ten: Smooth Muscle Phenotypic Diversity: Effect on Vascular Function and Drug Responses

• Abstract
• 1 Introduction
• 2 Brief Review of the Players in VSM Contractile Function
• 3 Diversity Within the Vascular System
• 4 Agonist-Mediated Vasoconstriction and Its Antagonism
• 5 Signaling-Mediated Vasodilation and Its Agonism
• 6 Calcium Flux and Its Inhibition
• 7 Diversity Within Human Populations
• 8 Conclusion
• Conflict of Interest
• Acknowledgment