
Underwood's Pathology: a Clinical Approach
- 8th Edition - June 25, 2024
- Imprint: Elsevier
- Editor: Simon S. Cross
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 1 9 4 9 - 1
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 1 6 9 9 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 1 7 4 2 - 8
A thorough understanding of pathology is crucial for doctors and a foundation for safe and effective clinical practice. This internationally renowned, award-winning textbook… Read more

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Request a sales quoteA thorough understanding of pathology is crucial for doctors and a foundation for safe and effective clinical practice. This internationally renowned, award-winning textbook provides a comprehensive overview, aligned to the needs of current medical students and early career stage doctors.
The book starts with a clear introduction to the basic principles of pathology, then moves on to more detailed discussion of disease mechanisms and the pathology of specific disorders ordered by body system. The text has been fully updated for this eighth edition and optimized for efficient study.
Complete with unrivalled photographs, images, graphics and supplementary electronic materials, Underwood’s Pathology is the complete learning package no medical student should be without.
The book starts with a clear introduction to the basic principles of pathology, then moves on to more detailed discussion of disease mechanisms and the pathology of specific disorders ordered by body system. The text has been fully updated for this eighth edition and optimized for efficient study.
Complete with unrivalled photographs, images, graphics and supplementary electronic materials, Underwood’s Pathology is the complete learning package no medical student should be without.
- Comprehensive but concise and understandable for medical students - also suitable for junior doctors, early career pathologists/histopathologists, dental students and biomedical scientists
- Ideal for integrated, systems-based courses and problem-based learning – reflects modern medical curricula
- Structure makes content highly accessible – easy to look up any pathology seen in the classroom or on the wards
- Presents pathology in the context of modern cellular and molecular biology and contemporary clinical practice
- Unrivalled collection of nearly 700 clinical photographs, histopathology images and graphics
- Includes a full patient symptoms index plus multiple quick-reference summary tables
- Prepared by leading pathology experts and educators – for coverage you can trust
- A complete eBook with BONUS electronic materials further supports and enhances the learning experience
Medical students
- Cover image
- Title page
- Table of Contents
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- Copyright
- Preface
- Contributors
- Acknowledgements
- Index of Patient Symptoms
- Part 1: Basic Pathology
- 1. What is pathology?
- History of Pathology
- Scope of Pathology
- Techniques of Pathology
- Learning Pathology
- Making Diagnoses
- Pathology, Patients and Populations
- Further Reading
- 2. What is disease?
- WHAT IS DISEASE?
- FURTHER READING
- 3. What causes disease?
- CAUSES OF DISEASE
- GENETIC ABNORMALITIES IN DISEASE
- DISEASES DUE TO GENETIC DEFECTS
- ENVIRONMENTAL FACTORS
- INFECTIVE AGENTS
- FURTHER READING
- Part 2: Disease Mechanisms
- 4. Disorders of growth, differentiation and morphogenesis
- DEFINITIONS
- NORMAL GROWTH, DIFFERENTIATION AND MORPHOGENESIS
- ABNORMALITIES OF GROWTH, DIFFERENTIATION AND MORPHOGENESIS
- FURTHER READING
- 5. Responses to cellular injury
- CELLULAR INJURY
- REPAIR AND REGENERATION
- INJURY DUE TO IONISING RADIATION
- FURTHER READING
- 6. Disorders of metabolism and homoeostasis
- INBORN ERRORS OF METABOLISM
- ACQUIRED METABOLIC DISORDERS
- METABOLIC CONSEQUENCES OF MALNUTRITION
- OBESITY
- TRACE ELEMENTS AND DISEASE
- TISSUE DEPOSITIONS
- FURTHER READING
- 7. Ischaemia, infarction and shock
- NONTHROMBOEMBOLIC VASCULAR INSUFFICIENCY
- THROMBOEMBOLIC VASCULAR OCCLUSION
- INFARCTION
- SHOCK
- FURTHER READING
- 8. Immunology and immunopathology
- DEFENCE AGAINST INFECTION
- KEY MOLECULES
- STRUCTURAL ORGANISATION OF THE IMMUNE SYSTEM
- FUNCTIONAL ORGANISATION OF THE IMMUNE RESPONSE
- NONSPECIFIC EFFECTOR MECHANISMS
- OUTCOMES OF IMMUNE RESPONSES
- IMMUNODEFICIENCY
- HYPERSENSITIVITY REACTIONS
- AUTOIMMUNITY AND AUTOIMMUNE DISEASE
- PRINCIPLES OF ORGAN TRANSPLANTATION
- FURTHER READING
- 9. Inflammation
- ACUTE INFLAMMATION
- CHRONIC INFLAMMATION
- FURTHER READING
- 10. Neoplasia and carcinogenesis
- GENERAL CHARACTERISTICS OF NEOPLASMS (TUMOURS)
- CLASSIFICATION OF TUMOURS
- NOMENCLATURE OF TUMOURS
- BIOLOGY OF TUMOUR CELLS
- BEHAVIOUR OF TUMOURS
- EARLY DETECTION OF CANCER BY SCREENING
- CARCINOGENESIS
- CELLULAR AND MOLECULAR EVENTS IN CARCINOGENESIS
- HALLMARKS OF CANCER
- FURTHER READING
- WEBSITES
- 11. Ageing and death
- AGEING
- DEATH
- FURTHER READING
- 12. How do pathologists help patient care?
- TYPES OF LABORATORY TESTS
- SPECIALISED TESTS
- AUTOPSIES
- FURTHER READING
- Part 3: Systematic Pathology
- 13. Cardiovascular system
- COMMON CLINICAL PROBLEMS FROM CARDIOVASCULAR DISEASE
- DISEASES OF THE HEART, ARTERIES AND OTHER VESSELS
- CARDIAC DISEASE
- FURTHER READING
- 14. Respiratory system
- COMMON CLINICAL PROBLEMS FROM RESPIRATORY TRACT DISEASE
- NORMAL STRUCTURE AND FUNCTION
- PULMONARY FUNCTION TESTS
- RESPIRATORY FAILURE
- DISEASES OF INFANCY AND CHILDHOOD
- NASAL PASSAGES, MIDDLE EAR AND SINUSES
- LARYNX
- LUNGS
- FURTHER READING
- 15. Alimentary system
- COMMON CLINICAL PROBLEMS FROM ALIMENTARY SYSTEM DISEASE
- MOUTH, TEETH, PHARYNX AND SALIVARY GLANDS
- OESOPHAGUS
- STOMACH
- INTESTINE
- APPENDIX
- ANUS AND ANAL CANAL
- FURTHER READING
- 16. Liver, biliary system and pancreas
- COMMON CLINICAL PROBLEMS FROM LIVER AND BILIARY SYSTEM DISEASE
- LIVER
- BILIARY SYSTEM
- PAEDIATRIC LIVER DISEASE
- PANCREAS
- FURTHER READING
- WEBSITES
- 17. Endocrine system
- COMMON CLINICAL PROBLEMS FROM ENDOCRINE DISEASE
- NORMAL STRUCTURE AND FUNCTION
- ENDOCRINE PATHOLOGY
- PITUITARY
- PINEAL GLAND
- ADRENALS
- THYROID
- PARATHYROIDS
- ENDOCRINE PANCREAS
- FURTHER READING
- 18. Breast
- COMMON CLINICAL PRESENTATIONS OF BREAST DISEASE
- NORMAL STRUCTURE AND FUNCTION
- CLINICAL FEATURES OF BREAST LESIONS
- DIAGNOSTIC METHODS
- INFLAMMATORY CONDITIONS
- PROLIFERATIVE CONDITIONS OF THE BREAST
- BENIGN TUMOURS
- BREAST CARCINOMA
- OTHER TUMOURS
- FURTHER READING
- WEBSITES
- 19. Female genital tract
- Common Clinical Problems From Female Genital Tract Disease
- Normal Development
- Vulva
- Nonneoplastic Epithelial Disorders
- Neoplastic Epithelial Disorders
- Vagina and Cervix
- Cervical Squamous Neoplasia
- Glandular Neoplasia of the Cervix
- Other Malignant Tumours
- Uterine Corpus
- Congenital Abnormalities
- The Normal Endometrium and Menstrual Cycle
- Abnormalities of the Endometrium
- Abnormalities of the Myometrium
- Ovary
- Ovarian Cysts
- Ovarian Stromal Hyperplasia and Stromal Luteinisation
- Endometriosis
- Ovarian Neoplasms
- Fallopian Tubes
- Pathology of Pregnancy
- Hydatidiform Mole
- Pathology of the Full-Term Placenta
- Pathology of the Umbilical Cord and Membranes
- Pathology of the Placental Bed
- Ectopic Pregnancy
- Maternal Death
- Further Reading
- 20. Urinary and male genital tracts
- COMMON CLINICAL PROBLEMS FROM DISEASES OF THE MALE GENITOURINARY TRACT
- URINARY CALCULI
- RENAL TUMOURS
- URETERS
- BLADDER
- TUMOURS OF THE BLADDER
- PROSTATE GLAND
- PENIS AND SCROTUM
- URETHRA
- TESTIS
- EPIDIDYMIS AND CORD
- FURTHER READING
- 21. Kidney diseases
- COMMON CLINICAL PROBLEMS FROM KIDNEY DISEASE
- INTRODUCTION
- FUNCTIONS OF THE KIDNEY
- GLOMERULAR DISEASES
- TUBULAR DISORDERS
- VASCULAR DISEASES
- URINARY TRACT OBSTRUCTION AND INFECTIONS
- CYSTIC RENAL DISEASES
- CONGENITAL ANOMALIES
- RENAL TRANSPLANTATION
- FURTHER READING
- 22. Lymph nodes and extranodal lymphoid tissue, spleen and thymus
- COMMON CLINICAL PROBLEMS ARISING FROM DISEASES OF LYMPH NODES, EXTRANODAL LYMPHOID TISSUES, SPLEEN AND THYMUS
- INVESTIGATION OF LYMPH NODE DISEASE
- LYMPH NODES
- SPLEEN
- THYMUS
- FURTHER READING
- 23. Blood and bone marrow
- COMMON CLINICAL PROBLEMS IN BLOOD AND BONE MARROW DISEASE
- COMPOSITION, PRODUCTION AND FUNCTIONS OF BLOOD
- NEOPLASTIC DISORDERS OF THE BONE MARROW
- DISORDERS OF BLOOD COAGULATION AND HAEMOSTASIS
- FURTHER READING
- 24. Skin
- COMMON CLINICAL PROBLEMS FROM SKIN DISEASE
- NORMAL STRUCTURE AND FUNCTION
- CLINICAL ASPECTS OF SKIN DISEASES
- INFLAMMATORY CELL TYPES AND SKIN DISEASE
- INFECTIONS
- COMMON NONINFECTIOUS INFLAMMATORY DISEASES (INFLAMMATORY DERMATOSES)
- EPIDERMAL CELLS
- MELANOCYTES
- DERMAL VESSELS
- ADNEXA
- DERMAL CONNECTIVE TISSUES
- DEPOSITS
- CUTANEOUS NERVES
- BEHAVIOUR AND THE SKIN
- TOXINS AND THE SKIN
- SKIN MANIFESTATIONS OF INTERNAL AND SYSTEMIC DISEASE
- FURTHER READING
- 25. Osteoarticular and connective tissues
- COMMON CLINICAL PROBLEMS FROM OSTEOARTICULAR AND CONNECTIVE TISSUE DISEASE
- Bone
- JOINTS
- CONNECTIVE TISSUES
- FURTHER READING
- 26. Central and peripheral nervous systems
- COMMON CLINICAL MANIFESTATIONS OF CENTRAL AND PERIPHERAL NERVOUS SYSTEM DISEASE
- CENTRAL NERVOUS SYSTEM
- PERIPHERAL NERVOUS SYSTEM
- THE EYE
- THE EAR
- FURTHER READING
- Websites
- Glossary
- Index
- Confidence is ClinicalKey
- Edition: 8
- Published: June 25, 2024
- Imprint: Elsevier
- No. of pages: 768
- Language: English
- Paperback ISBN: 9780443119491
- Paperback ISBN: 9780443116995
- eBook ISBN: 9780443117428
SC
Simon S. Cross
Affiliations and expertise
Professor of Diagnostic Histopathology and Honorary Consultant, Histopathologist, Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry & Health, The University of Sheffield, Beech Hill Road, Sheffield, UK