Understanding Pathophysiology Australia and New Zealand Edition

4th Edition - September 1, 2022
Imprint: Elsevier
Authors: Judy Craft, Christopher Gordon, Sue E. Huether, Kathryn L. McCance, Valentina L. Brashers
Language: English
Paperback ISBN:
9 7 8 - 0 - 7 2 9 5 - 4 3 9 1 - 0
eBook ISBN:
9 7 8 - 0 - 7 2 9 5 - 9 7 7 3 - 9

Purchase options

World Book Day Celebration!

Save up to 30% on books and eBooks!

Shop now

Institutional subscription on ScienceDirect

Request a sales quote

Cover image
Title page
Table of Contents
Copyright
About the editors
Australian and New Zealand contributors
US contributors
Reviewers
Preface
Text features
List of Illustrations
List of Tables
Part 1. Essential concepts of pathophysiology
Introduction
1. Introduction to clinical science
Introduction
Essential pathophysiology
Essential anatomy
Essential physiology
Essential chemistry
Essential physics
2. Homeostasis
Introduction
Homeostasis
Regulation of homeostasis
Disturbances of homeostasis lead to pathophysiology
3. Cell structure and function
Introduction
Cell structure and function
Cell components
The cell membrane
Cell receptors and communication
Membrane transport
Cell metabolism
Tissues
Nervous tissue
4. Altered cell function
Introduction
Causes of cell injury
Mechanisms of cell injury
Cell adaptation
Reversible and irreversible cell injury
Death
5. Genes
Introduction
The nucleus
Cell proliferation
DNA, RNA and proteins: Heredity at the molecular level
Elements of genetics
Inheritance of traits
Newborn screening
Part 2. Alterations to regulation and control
Introduction
6. The structure and function of the neurological system
Introduction
Organisation of the nervous system
Cells of the nervous system
Neuron injury and regeneration
Neuron communication
The central nervous system
The peripheral nervous system
The autonomic nervous system
Sensory function
7. Pain
Introduction
The definition of pain
Types of pain
Pain terminology
The physiology of pain
Clinical manifestations of pain
Evaluation and treatment
Pathophysiology of pain
8. Concepts of neurological dysfunction
Introduction
Alterations in cerebral homeostasis
Alterations in cognitive function
Alterations in motor function
9. Alterations of neurological function across the life span
Introduction
Cerebrovascular disorders
Trauma to the central nervous system
Degenerative disorders of the central nervous system
Peripheral nervous system and neuromuscular junction disorders
Infection and inflammation of the central nervous system
Tumours of the nervous system
10. The structure and function of the endocrine system
Introduction
Mechanisms of hormonal regulation
The structure and function of the endocrine glands
11. Alterations of endocrine function across the life span
Introduction
Mechanisms of hormonal alterations
Alterations of pituitary function
Alterations of adrenal function
Alterations of pancreatic function
Alterations of thyroid function
Alterations of parathyroid function
Part 3. Alterations to protection and movement
Introduction
12. The structure and function of the immune system
Introduction
Human defence mechanisms
Humoral and cell-mediated immunity
Induction of the immune response
13. Inflammation and fever
Introduction
Acute inflammation
Cellular components of inflammation
Inflammatory mediators
Plasma protein systems
Chronic inflammation
Clinical manifestations of inflammation
Fever
Wound healing
14. Infection
Introduction
Infection rates
Definitions
Microorganisms
Antimicrobials
Vaccines
Infections
Antimicrobial resistance
15. Alterations of immune function across the life span
Introduction
Hypersensitivity reactions
Transplantation
The abo blood group system
Autoimmune diseases
Immune deficiencies
16. The structure and function of the haematological system
Introduction
Components of the haematological system
The development of blood cells
The mechanisms of haemostasis
17. Alterations of haematological function across the life span
Introduction
Alterations of erythrocyte function
Alterations of platelets and coagulation
Alterations of leucocytes
Alterations of lymphoid function
18. The structure and function of the integumentary system
Introduction
The structure of the skin
Appendages of the skin
The function of the integumentary system
19. Alterations of the integumentary system across the life span
Introduction
Skin lesions
Skin cancer
Inflammatory disorders of the skin
Infections of the integumentary system
Traumatic conditions of the integumentary system
Vascular disorders
20. The structure and function of the musculoskeletal system
Introduction
The structure and function of bones
The structure and function of joints
The structure and function of skeletal muscles
21. Alterations of musculoskeletal function across the life span
Introduction
Musculoskeletal injuries
Disorders of bone and joints
Disorders of skeletal muscle
Integrative conditions related to the musculoskeletal system
Part 4. Alterations to body maintenance
Introduction
22. The structure and function of the cardiovascular and lymphatic systems
Introduction
The circulatory system
The structure of the heart
Blood flow during the cardiac cycle
The coronary circulation
Structures that control heart function
The electrocardiogram
Factors affecting cardiac performance
The physiology of cardiovascular control
The systemic circulation
Blood pressure and blood flow
The lymphatic system
23. Alterations of cardiovascular function across the life span
Introduction
Alterations of blood flow and pressure
Alterations of the heart wall
Alterations of cardiac conduction
Heart failure
Shock
24. The structure and function of the pulmonary system
Introduction
The structure of the pulmonary system
The function of the pulmonary system
25. Alterations of pulmonary function across the life span
Introduction
Disorders of the pulmonary system
Infections of the pulmonary system
Lung cancer
Obstructive sleep apnoea
Alterations of pulmonary blood flow and pressure
Clinical manifestations of pulmonary alterations
26. The structure and function of the digestive system
Introduction
The mouth, pharynx and oesophagus
The stomach
The small intestine
Accessory organs of digestion
The large intestine
An overview of nutrition
27. Alterations of digestive function across the life span
Introduction
Disorders of the gastrointestinal tract
Clinical manifestations of gastrointestinal tract alterations
Disorders of the hepatobiliary system and pancreas
28. The structure and function of the urinary system
Introduction
The structure of the kidneys
The function of the kidneys
Urine
Urinary structures
Micturition
29. Fluids and electrolytes, acids and bases
Introduction
Fluid balance
Electrolyte balance
Acid–base balance
30. Alterations of renal and urinary tract function across the life span
Introduction
Urinary tract obstruction
Urinary tract infection
Glomerular disorders
Chronic kidney disease
Acute kidney injury
Tumours
Part 5. Alterations to continuity
Introduction
31. The structure and function of the reproductive systems
Introduction
The structure and function of the male reproductive system
The structure and function of the female reproductive system
Puberty in males and females
Gametogenesis
Male and female sexual responses
Conception, gestation and parturition
32. Alterations of the reproductive systems across the life span
Introduction
Classification of reproductive system alterations
Cancer
Disorders of the female reproductive system
Disorders of the male reproductive system
Diverse sex development
Disorders of the breast
Fertility
Assisted reproductive technologies
Main sexually transmitted infections
Part 6. Contemporary health issues
Introduction
33. Introduction to contemporary health issues
Introduction
Australia and New Zealand: Demographics
Chronic diseases
Mental health
Indigenous health
Contemporary lifestyle
Obesity
34. Stress and chronic disease
Introduction
The general adaptation syndrome
Stressors
The detection of stress
Physiological processes of the stress response
Physiological effects of the stress response
Benefits of the stress response
Health alterations with chronic stress
Modulation of the stress response
Stress and sleep
35. Obesity
Introduction
The progression to overweight and obesity
Evaluation of body size
Obesity
Metabolic syndrome
36. Type 2 diabetes
Introduction
Diabetes mellitus
Diagnosis of type 2 diabetes
Risk factors for the development of type 2 diabetes
Management of diabetes
Complications of diabetes
37. Cancer
Introduction
Cancer is a chronic disease
Cancer characteristics and terminology
The genetic basis of cancer
Types of gene mutations in cancer
Cancer, immunity, inflammation and infection
Risk factors and cancer
Gene–environment interaction
Diagnosis and evaluation of cancer
Clinical manifestations of cancer and cancer treatments
Cancer treatments
Cancers of greatest significance in Australia and New Zealand
Cancer across the life span
38. Genes, genetic diseases and the environment
Introduction
Studying genetic disease
Genetic disorders
Single gene disorders
Multifactorial inheritance
Conditions arising from genetic and environmental factors
The relative importance of genetic and environmental contributions to disease
The prevention of disease
Genetic screening
39. Neurobiology of mental illness
Introduction
The epidemiology of mental illness in Australia and New Zealand
Genetics and mental illness
Neurotransmitters
Classification systems
Anxiety disorders
Mood disorders
Schizophrenia
Substance use
Eating disorders
Personality disorders
40. Indigenous health issues in Australia
Introduction
The indigenous Australian population
Indigenous health
Conditions affecting the wellbeing of indigenous Australian people
Common threads — factors contributing to health problems
Social determinants of indigenous health
Closing the gap
41. Māori health in Aotearoa New Zealand
Introduction
The New Zealand Māori population
Māori health
Conditions affecting the wellbeing of Māori
Factors contributing to health problems
Social determinants of Māori health
Appendix A: Reference laboratory values
Appendix B: Prefixes, suffixes and root words commonly used in health sciences
Glossary
References
Image and text credits
Index

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Understanding Pathophysiology Australia and New Zealand Edition

Purchase options

World Book Day Celebration!

Institutional subscription on ScienceDirect

Judy Craft

Christopher Gordon

Sue E. Huether

Kathryn L. McCance

Valentina L. Brashers

Related books