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Understanding Immunology
- 1st Edition - November 12, 2012
- Editor: Alastair J. Cunningham
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 3 9 6 0 4 3 - 6
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 3 9 0 7 - 6
Understanding Immunology deals with immunology and its unifying principles, based on the view that the immune system has evolved to combat infectious disease. This book describes… Read more
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Request a sales quoteUnderstanding Immunology deals with immunology and its unifying principles, based on the view that the immune system has evolved to combat infectious disease. This book describes the phylogenetic emergence of the immune system; immune reactions in invertebrates and vertebrates; antibody-antigen reactions and the induction of the antibody response; the development of the immune repertoire and self-tolerance; and memory and tolerance in T-cells. This text is organized into 15 chapters and begins with an overview of the immune system, paying particular attention to its basic requirements and properties. This book then discusses antibodies and antigens; the molecular biology of antibody formation; and the role of lymphocytes, lymphoid tissue, and antibody forming cells in the immune response. The following chapters focus on immunocompetent cells and the mechanisms of cell cooperation in the induction of the antibody response, properties of the cells responsible for memory, and the genetic basis of antibody diversity. The reader is also introduced to allelic exclusion and the ontogeny of the immune repertoire; differentiation of T-cells; and cancer and transplantation immunology. The remaining chapters explore aberrations of the immune system and immunity to infectious disease. A comparison of the strategies of vertebrates and invertebrates in adapting to unexpected changes in the environment concludes the book. This book will prove useful as an introduction to immunology to those with some background in biology, particularly, undergraduate or graduate students as well as established researchers in other fields.
Preface
1 Basic Requirements and Properties of an Immune System
1.1 The Basic Pattern of an Immune Response
1.2 Basic Requirements of an Immune System
1.3 Summary
Further Reading
Questions
2 The Reaction of Antibody with Antigen
2.1 Main Properties of Antibodies
2.2 Ways of Detecting Antibody
2.3 Specificity and Diversity of Antibody
2.4 Protective Immunity
2.5 Summary
Further Reading
Questions
3 Molecular Biology of Antibody Formation
3.1 Gross Structure of Ig G. Myelomas
3.2 Other Ig Classes
3.3 Allotypes
3.4 Amino Acid Sequences: V Regions
3.5 Two Genes, One Polypeptide Chain
3.6 How Many V Genes?
3.7 Molecular Hybridization
3.8 Evolution of Ig Genes
3.9 Summary
Further Reading
Questions
4 Lymphocytes, Lymphoid Tissue, and Antibody Forming Cells
4.1 The Single Cell as the Unit in Immunology
4.2 Lymphoid Tissue
4.3 Local Antigenic Stimulation
4.4 General Pattern of Cellular Events in an Immune Response
4.5 Methods for Detecting Single Antibody Forming Cells
4.6 Properties of the Antibody Forming Cell
4.7 Kinetics of Appearance of Antibody Forming Cells in Lymphoid Tissue
4.8 Antibody Feedback
4.9 Clonal Proliferation of Antibody Forming Cells
4.10 Summary
Further Reading
Questions
5 Immunocompetent Cells and Induction of the Antibody Response
5.1 Immunocompetent Cells
5.2 The Immunocompetent B Cell
5.3 The Immunocompetent T Cell
5.4 Cell Cooperation in the Induction of Antibody Formation
5.5 Mechanisms of Cell Cooperation
5.6 Summary
Further Reading
Questions
6 Memory and Tolerance
6.1 Examples of Memory
6.2 Facts about Memory
6.3 What Causes Memory?
6.4 Properties of the Cells Responsible for Memory
6.5 Generation of Memory Cells
6.6 "Maturation of Affinity"
6.7 Tolerance
6.8 Facts about Tolerance
6.9 What Causes Tolerance?
6.10 The Cells Affected in Tolerance
6.11 Summary
Further Reading
Questions
7 Antibody Diversity: Its Genetic Basis
7.1 Instruction versus Selection
7.2 Germline versus Somatic Mutation
7.3 Which Is Correct-Germline or Somatic Mutation?
7.4 Summary
Further Reading
Questions
8 Development of the Immune Repertoire and Self-Tolerance in the Individual
8.1 Allelic Exclusion
8.2 Self-Tolerance Is Acquired
8.3 Views on Generation of Diversity
8.4 Ontogeny of the Immune Repertoire
8.5 General Remarks
8.6 Summary
Further Reading
Questions
9 More about T Cells
9.1 Differentiation of T Cells
9.2 Immune Receptors on T Cells
9.3 Memory and Tolerance in T Cells
9.4 T Cell Effector Functions
9.5 Summary
Further Reading
Questions
10 Transplantation Immunology
10.1 Graft Rejection
10.2 Terminology
10.3 Evidence that Graft Rejection Is an Immunological Process
10.4 Transplantation Antigens
10.5 Rejection Mechanisms
10.6 Graft versus Host Reactions
10.7 Transplantation Tolerance
10.8 Mixed Lymphocyte Reaction
10.9 Anomalous Features of Allogeneic Reactions
10.10 Possible Explanations for the Anomalies in Allogeneic Reactions
10.11 Preventing Graft Rejection
10.12 Summary
Further Reading
Questions
11 Regulation of the Immune Response
11.1 Degeneracy of Immune Responses
11.2 Suppressor Regulation of Immune Responses
11.3 Genetic Control of Immune Responses
11.4 Summary
Further Reading
Questions
12 Aberrations of the Immune System: Immune Deficiency, Allergy, and Autoimmune Disease
12.1 Immunological Deficiency Diseases
12.2 Allergic or Hypersensitivity Reactions
12.3 Autoimmune Disease
12.4 Summary
Further Reading
Questions
13 Immunity to Infectious Disease
13.1 Immune Mechanisms
13.2 Acquired Immunity
13.3 The Immune Response to Different Classes of Invading Organisms
13.4 Immunological Intervention
13.5 Summary
Further Reading
Questions
14 Cancer Immunology
14.1 Development of a Tumor
14.2 What Provokes Cancer?
14.3 Immune Control of Cancer
14.4 The Immune Surveillance Hypothesis
14.5 Possible Immunotherapy against Cancer
14.6 Summary
Further Reading
Questions
15 Evolution of the Immune System
15.1 A Recapitulation of the Properties of the Vertebrate Immune System
15.2 Phylogenetic Emergence of an Immune System
15.3 How Do Many Organisms Manage without an Immune System?
15.4 Comparison of the Strategies of Vertebrates and Invertebrates
15.5 Summary
Further Reading
Appendix: Answers to Questions
Index
- No. of pages: 268
- Language: English
- Edition: 1
- Published: November 12, 2012
- Imprint: Academic Press
- Paperback ISBN: 9780123960436
- eBook ISBN: 9780323139076
AC
Alastair J. Cunningham
Affiliations and expertise
John Curtin School of Medical Research