
Tyrosinase
- 1st Edition, Volume 56 - September 18, 2024
- Imprint: Academic Press
- Editor: Claudiu T. Supuran
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 9 5 2 0 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 9 5 2 1 - 8
Tyrosinase, Volume 56 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Ove… Read more

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Request a sales quoteTyrosinase, Volume 56 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Overview on tyrosinases (genetics, molecular biology, phylogenetic relationship), Catalytic mechanism of tyrosinases, Structural characterization of tyrosinases, Assay methods of tyrosinase activity and inhibition, Natural products as tyrosinase inhibitors, Drug design of tyrosinase inhibitors, Peptide and peptidomimetic tyrosinase inhibitors, Computational studies of tyrosinase inhibitors, Bacterial tyrosinases and their inhibitors, and Biomedical applications of tyrosinases and tyrosinase inhibitors.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in The Enzymes series
- Highlights new advances on Tyrosinase
Life science researchers, biochemists, medical scientists
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Preface
- Chapter One: Overview on tyrosinases: Genetics, molecular biology, phylogenetic relationship
- Abstract
- 1 Introduction
- 2 Structural homology and functional divergence in TYRs and hemocyanins
- 3 Evolutionary dynamics and functional diversification of type-3 copper proteins
- 4 Structural characteristics of TYR proteins
- 5 Structural features of bacterial TYRs
- 6 Structural role of cysteine residues in TYR proteins: implications for stability and function across organisms
- 7 Conclusions
- References
- Chapter Two: Catalytic mechanism of tyrosinases
- Abstract
- 1 Introduction
- 2 The overall architecture of the TYR active site
- 3 Oxidation states of the TYR active site
- 4 TYR mechanism
- 5 Monophenolase activity of TYR
- 6 Diphenolase activity of TYR
- 7 TYR inhibition
- 8 Conclusion
- References
- Chapter Three: Structural characterization of tyrosinases and an update on human enzymes
- Abstract
- 1 Structure and function of the tyrosinases
- 2 Structure and mechanism of tyrosinase
- 3 Tyrosinase: structure and inhibitor complexes
- 4 Exploring tyrosinase: health and biotech
- References
- Chapter Four: Natural products as tyrosinase inhibitors
- Abstract
- 1 Introduction
- 2 Natural sources of tyrosinase inhibitors
- 3 Natural tyrosinase inhibitors and derivatives
- 4 Other natural tyrosinase inhibitors
- 5 Conclusions
- Conflicts of interest
- References
- Chapter Five: Drug design of tyrosinase inhibitors
- Abstract
- 1 Introduction
- 2 Recent compounds tested on human and mushroom tyrosinases
- 3 Conclusions and future perspectives
- Acknowledgments
- References
- Chapter Six: Peptide and peptidomimetic tyrosinase inhibitors
- Abstract
- Abbreviations
- 1 Introduction
- 2 Amino acids with anti-tyrosinase properties
- 3 Anti-tyrosinase peptides from natural sources
- 4 Anti-tyrosinase peptides synthetically produced
- 5 Peptidomimetics
- 6 Conclusions
- References
- Chapter Seven: Computational studies of tyrosinase inhibitors
- Abstract
- 1 Introduction
- 2 Application of in silico methods to TYR inhibitors
- 3 Conclusion
- References
- Chapter Eight: Bacterial tyrosinases and their inhibitors
- Abstract
- 1 Introduction
- 2 Catalytic mechanism of bacterial tyrosinases
- 3 Biosynthetic strategy of melanin synthesis by bacterial tyrosinases
- 4 Tyrosinase inhibition mechanism
- 5 Bacterial tyrosinase inhibitors
- 6 Conclusion and future perspective of bacterial tyrosinase
- References
- Chapter Nine: Biomedical applications of tyrosinases and tyrosinase inhibitors
- Abstract
- 1 Introduction
- 2 Melanin depigmentation disturbances
- 3 Increased melanin biosynthesis diseases and their management
- 4 Melanoma and tyrosinase
- 5 Tyrosinase inhibitors in cosmesis and preclinical/clinical settings
- 6 Food applications of tyrosinase inhibitors
- 7 Bacterial tyrosinases
- 8 Conclusions
- References
- Edition: 1
- Volume: 56
- Published: September 18, 2024
- No. of pages (Hardback): 294
- No. of pages (eBook): 282
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443295201
- eBook ISBN: 9780443295218
CS
Claudiu T. Supuran
Dr. Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990, he became Assistant and then Associate Professor of Chemistry at the University of Bucharest. He was Visiting Scholar at the University of Florida, Gainesville, United States, at Griffith University, Brisbane, Australia, and Visiting Professor at University of La Plata, Argentina. In 1995 he moved to the University of Florence, Italy, where he is currently Full Professor in the Department of Neuroscience, Psychology, Medicine and Child Health. His main research interests include design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates, and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1900 papers in these fields.
Affiliations and expertise
Full Professor, University of Florence, Neuroscience, Psychology, Medicine and Child Health, Florence, ItalyRead Tyrosinase on ScienceDirect