Twin and Family Studies of Epigenetics
- 1st Edition, Volume 27 - August 19, 2021
- Imprint: Academic Press
- Editors: Shuai Li, Trygve O. Tollefsbol, John Hopper
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 0 9 5 1 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 0 9 5 2 - 3
Twin and Family Studies of Epigenetics, Volume 27, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research… Read more
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Request a sales quoteTwin and Family Studies of Epigenetics, Volume 27, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more.
Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects.
- Offers a practical, interdisciplinary approach across epigenetics, epidemiology and various disease specialties
- Applies epigenetic twin and family studies to determine the relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity and high blood pressure, among other diseases and disorders
- Features chapter contributions from a wide range of international researchers in the field
Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, reproductive biology, epidemiology, public health, bioinformatics, and endocrinology; life science researchers; oncologists; obstetricians; pediatricians; immunologists; bioengineers; developmental biologists
clinicians and graduate students in the biosciences
clinicians and graduate students in the biosciences
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Part 1: Introduction
- Chapter 1: Value of twin and family study designs for epigenetic research
- Abstract
- 1: Introduction
- 2: Quantifying genetic and environmental influences on variation in epigenetic modification, heritability and the equal environment assumption
- 3: Controlling for the effects of genetic and non-genetic factors shared within the family
- 4: Facilitating causation assessment
- 5: Addressing issues of specific relevance to twins
- 6: Summary
- Chapter 2: Evaluation and measurement of epigenetic modifications in population-based studies
- Abstract
- Conflicts of interest, Acknowledgments, Funding information, and Author contributions
- 1: What is epigenetics?
- 2: Profiling epigenetic alterations
- 3: Analysis of epigenetic profiling
- 4: Public epigenetic resources
- 5: Future directions
- Part 2: Human health applications
- Chapter 3: Discordant monozygotic twin studies of epigenetic mechanisms in mental health
- Abstract
- Acknowledgments
- 1: Introduction
- 2: An overview of MZ twin studies of epigenetic mechanisms in personality behavior and mental health
- 3: Discussion and conclusions
- Chapter 4: DNA methylation and breast cancer risk: value of twin and family studies
- Abstract
- 1: Introduction
- 2: Within-family designs
- 3: Designs enriched for breast cancer familial features
- 4: Other study designs
- 5: Literature summaries
- 6: Example study
- 7: Future directions
- 8: Summary
- Chapter 5: Twin and family studies on epigenetics and oral health
- Abstract
- 1: Introduction
- 2: Dental caries
- 3: Twin and family studies of epigenetics and enamel hypomineralization
- 4: Twin and family studies of epigenetics and periodontal disease
- 5: Twin and family studies of tooth morphology and emergence
- 6: Challenges facing twin and family genetic and epigenetic studies of dental caries
- 7: Summary
- Chapter 6: Twin and family epigenetic studies of type 2 diabetes
- Abstract
- 1: What is type 2 diabetes?
- 2: T2D and epigenetics
- 3: T2D epigenetics in twin and family studies
- 4: Conclusion
- Chapter 7: Twin and family studies on epigenetics and obesity
- Abstract
- Declaration of interest
- 1: Introduction
- 2: Twin studies of epigenetics and obesity
- 3: Family studies of epigenetics and obesity
- 4: Limitations of the data presented
- 5: Conclusions
- Chapter 8: DNA methylation and blood pressure in Chinese adult twins
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Methods
- 3: Statistical analysis
- 4: Results
- 5: Discussion
- 6: Conclusion
- Chapter 9: Twin and family studies on epigenetics of autoimmune diseases
- Abstract
- 1: Introduction
- 2: The human immune system
- 3: Autoimmune diseases
- 4: Twin and family-based studies of autoimmune diseases and epigenetics
- 5: Conclusions and future perspectives
- Chapter 10: Twin studies on the epigenetics of selected neurological disorders and carotid artery disease
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Twin studies on the epigenetics of multiple sclerosis
- 3: Twin studies on the epigenetics of Alzheimer’s disease
- 4: Twin studies on the epigenetics of carotid artery atherosclerosis
- 5: Summary and conclusion
- Chapter 11: Disease-discordant twin studies of epigenetics and cancer
- Abstract
- 1: Summary
- Chapter 12: Sex differences in epigenetic profiles: The value of twin studies
- Abstract
- Acknowledgments
- 1: Background
- 2: Demonstration
- 3: Discussion
- Part 3: Emerging approach
- Chapter 13: Combining twin-family designs with measured genetic variants to study the causes of epigenetic variation
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Combining twin-family designs with measured genetic variants to study the causes of epigenetic variation
- 3: Combining twin-family designs with measured genetic variants to study cause and effect
- 4: Overall conclusion
- Chapter 14: Imaging epigenetics and the radiogenomics
- Abstract
- 1: Introduction
- 2: The role of imaging in twin studies
- 3: Radiogenomics
- 4: Artificial intelligence, machine learning, and deep learning
- 5: Imaging epigenetics
- 6: Future of twin studies in imaging epigenetics
- 7: Conclusion
- Chapter 15: DNA methylation changes specific to environmental exposures: The strengths of twin studies using cigarette smoking as an example
- Abstract
- Acknowledgment
- 1: Introduction
- 2: DMRs associated with cigarette smoking
- 3: Exposure-specific DMRs
- 4: Predicting the past exposure using the exposure-specific DMRs
- 5: Conclusions
- Chapter 16: Time trends in epigenetic signatures and population health risks
- Abstract
- 1: Introduction
- 2: Assessment and prediction of time trends in health risks
- 3: Environmental factors driving time trends
- 4: Early life environmental exposures with lag time effects
- 5: Epigenetics as biological memory of early life environmental exposures
- 6: Birth cohorts, age, and period effects in time trends in health risks
- 7: Early life epigenetic signatures as predictors of later time trends in health risks
- 8: Time trends among twin pairs characterizing the time trends
- 9: Investigative requirements for twin studies
- 10: Gene–environment interactions possibly implicating epigenetics
- 11: Current feasibility and limitations in investigations of epigenetic mechanisms
- Chapter 17: Ambient air pollution and human epigenetic modifications
- Abstract
- 1: Introduction
- 2: Ambient air pollution and DNA methylation
- 3: Ambient air pollution and non-coding RNA
- 4: Ambient air pollution and histone modification
- 5: The value of twin and family studies
- 6: Summary
- Index
- Edition: 1
- Volume: 27
- Published: August 19, 2021
- Imprint: Academic Press
- No. of pages: 374
- Language: English
- Paperback ISBN: 9780128209516
- eBook ISBN: 9780128209523
SL
Shuai Li
Dr Shuai Li has long-term experience in analyzing data from twin and family studies, including the novel epigenomic data. His PhD uses twin and family studies to research DNA methylation. He has published more than 10 papers on epigenetic epidemiological studies, specializing in twin and family designs.
Affiliations and expertise
Centre for Epidemiology and Biostatistics, The University of Melbourne, Carlton, AustraliaTO
Trygve O. Tollefsbol
Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.
Affiliations and expertise
Distinguished Professor of Biology, University of Alabama at Birmingham, AL, USAJH
John Hopper
Professor John Hopper, AM, was one of the nine inaugural Australia Fellows awarded by NHMRC in 2007 and is currently a NHMRC Senior Principal Research Fellow. He is a Professorial Fellow with a PhD in Mathematical Statistics, and is currently Director (Research) of the Centre for Epidemiology and Biostatistics in the School of Population Global Health at The University of Melbourne. He has published more than 700 papers, specializing in the statistical methodology and its application for analyzing twin and family data, and addressing the genetic and environmental aetiology of diseases and health. He is principal or co-investigator on a number of case-control-family studies across a range of diseases and conditions, particularly breast cancer and colorectal cancer (both funded by the National Institutes of Health (USA)), prostate cancer, melanoma, childhood cancer and asthma. He is a co-investigator on several cohort studies, including Health 2020 and long term follow-up of the 1968 Tasmanian Asthma Study. Professor Hopper has been Director of the Australian Twin Registry (Now is Twins Research Australia) since 1990 and has been awarded a NHMRC CRE grant in Twin Research in 2014.
Affiliations and expertise
Centre for Epidemiology and Biostatistics, The University of Melbourne, Carlton, AustraliaRead Twin and Family Studies of Epigenetics on ScienceDirect