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Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics

  • 1st Edition - November 9, 2021
  • Latest edition
  • Editors: Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel, Colin R. Martin
  • Language: English

Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics is an essential read for anyone working in pain management. The book addresses the onset of pain, the… Read more

Description

Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics is an essential read for anyone working in pain management. The book addresses the onset of pain, the cause of the pain, and the administration of analgesia or anesthesia. The etiology of pain is complex and multi-factorial, which is made more complex with the use of analgesics and local or general anesthetics. This volume works to clarify all of the subjects pertinent to anesthesia and the brain, from their variety, modes of action, and adverse effects.

Key features

  • Provides a broad range of topics related to the neuroscience of analgesics and anesthetics
  • Contains chapter abstracts, key facts, a dictionary of terms, and summary points to aid in understanding
  • Discusses anesthesia types, mechanisms of action and affiliated effects
  • Helps readers navigate key areas for research and further clinical recommendations

Readership

Neurologists, anesthesiologists, pharmacologists, physiologists, psychologists, doctors, health care workers and experts in behavior. Academic libraries that covers the neuroscience of pain, anesthetics and analgesics. Undergraduates, postgraduate, lecturers, academic professors, and graduate students and trainees in the basic sciences or clinical disciplines who have an interest in pain mechanisms, diagnosis and/or management

Table of contents

I. Drugs and agents used in anesthesia and analgesia

1. Anesthesia for malignant hyperthermia susceptible patients
Helga Cristina Almeida da Silva, Calim Neder and Mariana Lima

2. Use of dextran in regional anesthesia
Masahiko Tsuchiya

3. Intraperitoneal local anesthetic agents in the management of post-operative pain
Karlin Sevensma

4. Automatic control of anesthesia via different vital signs
Jiann-Shing Shieh, Jerry Chen and Maysam F. Abbod

5. Non-opioid based analgesia in otolaryngology
Khanh K. Nguyen, Yohanan Kim and Anthony Sanchez

II. Mechanisms of action of drugs

6. Buprenorphine: mechanisms and applications
Anuj Aggarwal and Albert Lin

7. Caffeine usage in pain management
Thomas Weiser

8. Chloroprocaine: features and applications
Alain Borgeat

9. Clonidine: features and applications
Renato Gomez and Magda Lourenço Fernandes

10. An excursion into secondary pharmacology of fentanyls with potential implications for drug design: σ1 receptor
Piotr F. J. Lipiński

11. Isoflurane: mechanisms and applications
Alexander Bautista

12. The lidocaine patch: features and applications: post-thoracotomy pain and beyond
Alfonso Fiorelli

13. Memantine: features and application to chronic pain control
Harsha Shanthanna

14. Midazolam: Perioperative administration
Joe C. Hong

15. Intravenous paracetamol: features and applications
Ristiawan Muji Laksono and Isngadi Ahmad Wagimin

16. Prilocaine: mechanisms and applications
Sreekantha Babu Jonnalagadda

17. Sevoflurane: features and use in topical application for wound care
Manuel Gerónimo-Pardo

18. Tramadol as an analgesic
Ayman M. Mahmoud

III. Adverse effects, reactions and outcomes

19. Long-term effects of anaesthesia on the brain: an update on neurotoxicity
Rajkumar Rajendram

20. Neuraxial labour analgesia and breast feeding
Roberto Giorgio Maria F. Wetzl

21. Mechanistic Overview of How Opioid Analgesics Promote Constipation
Jesse Di Cello

22. Cognitive-behavioral therapy for opioid use disorder and chronic pain
Declan Barry

23. Preoperative opioid and benzodiazepines: impact on adverse outcomes
Martin Ingi Sigurdsson

24. Anesthetics, Malignant hyperthermia syndrome and Kv7 channels
Mariarosaria. Bucci, Valentina Vellecco, Antonio Mancini and Giuseppe Cirino

25. Problems with epidural catheter
Mustafa Kemal Arslantas

26. Headache after neuroaxial blocks: a focus on combined-epidural anesthesia
Reyhan Arslantas

27. Liposomal bupivacaine, pain relief and adverse events
Alparslan Turan

28. Adverse events associate with analgesics: a focus on paracetamol use
Grzegorz Porebski and Iwona Popiolek

IV. Novel and non-pharmacological aspects and treatments

29. Acronychia pedunculata leaves and usage in pain
U G Chandrika and W. M. K. M. Ratnayake

30. Adansonia digitata and use in neuropathic pain: prostaglandins and beyond
Aboyeji Lukuman Oyewole, Abdulmusawwir Alli-Oluwafuyi, Abdulrazaq Nafiu and Aminu Imam

31. Andrographis paniculata standardized extract (ParActin) and pain
Rafael A. Burgos

32. Capsaicin: features usage in diabetic neuropathic pain
Kongkiat Kulkantrakorn

33. Cola nitida and Pain reliefLawrence
Dayo Adedayo

34. Analgesic effects of Ephedra Herb extract and ephedrine alkaloids-free Ephedra Herb extract (EFE)
Sumiko Hyuga, Shunsuke Nakamori, Yoshiaki Amakura, Masashi Hyuga, Nahoko Uchiyama, Yoshinori Kobayashi, Takashi Hakamatsuka, Yukihiro Goda, Hiroshi Odaguchi and Toshihiko Hanawa

35. Euphorbia bicolor (Euphorbiaceae) Latex Phytochemicals and applications to analgesia
Paramita Basu, Dayna Loyd Averitt and Camelia Maier Maier

36. Pain relieving activity of muntingia calabura l.: elucidation of possible mechanisms of action and identification of responsible phytoconstituents
Zainul Amiruddin Zakaria

37. Resolving neuroinflammation and pain with Maresin 1, a specialized pro-resolving lipid mediator
Waldiceu A. Verri Jr., Victor Fattori, Camila Ferraz, Fernanda Soares Rasquel-Oliveira, Tiago H. Zaninelli, Sergio Marques Borghi and Rubia Casagrande

38. Therapeutic role of naringenin to alleviate inflammatory pain
Waldiceu A. Verri Jr., marilia Fernandes manchope, Camila Ferraz, Sergio Marques Borghi, Fernanda Soares Rasquel-Oliveira, Anelise Franciosi, Julia Bagatim de Souza, Amanda Martins Dionisio and Rubia Casagrande

39. Analgesic properties of Solanum paniculatum and S.torvum extracts
Francisco José Roma Paumgartten

40. Dietary constituents contribute to local anesthetic agent: neurophysiologicals mechanism of nociceptive pain
Mamoru Takeda

41. Pain response following prenatal stress and its modulation by antioxidants
C B Abd Aziz

42. Physical activity and fitness in the prevention of musculoskeletal pain in youth
Fernando Estevez-Lopez, Pablo Molina-García Sr. and Patrocinio Ariza-Vega

43. Linking aerobic exercise and childhood pain alleviation: a narrative
C. Cushing

44. Physical activity and exercise in the management of musculoskeletal pain: a focus on fibromyalgia
Fernando Estevez-Lopez

45. Spinal cord stimulation and limb pain
Usman Latif and Timothy Sowder

46. Effectiveness of neural mobilization on pain and disability in individuals with musculoskeletal disorders
Carlos Romero Morales

47. Virtual reality and applications to treating neck pain
M. Razeghi

48. Virtual reality-induced analgesia and dental pain
Elitsa Veneva

49. Vibrotactile devices, DentalVibe and local anesthesiaElitsa
Veneva, Ani Belcheva and Ralitsa D. Raycheva

50. Cooled radiofrequency ablation (CRFA) and osteoarthritis treatment for pain
Antonia Chen and Eric Moorhead

51. Non-pharmacologic analgesic therapies: a focus on photobiomodulation, acustimulation and cryoanalgesia (ice) therapy
Roya Yumul, Ofelia Loani Elvir Lazo and Paul Frederick White

52. New coping strategies and self-education for chronic pain management: e-health
Victoria Mazoteras Pardo, Marta San-Antolín, Daniel López-López, Ricardo Becerro-de-Bengoa-Vallejo, Marta Losa-Iglesias, Carlos Romero Morales, David Rodríguez-Sanz, Eva María Martinez-Jiménez and César Calvo-Lobo Sr.

53. Postoperative Pain Management Truncal blocks in obstetric and gynecologic surgery
Pelin Corman Dincer

Product details

  • Edition: 1
  • Latest edition
  • Published: November 9, 2021
  • Language: English

About the editors

RR

Rajkumar Rajendram

Dr Rajkumar Rajendram is a clinician-scientist with expertise in internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St Thomas’ Medical School, King’s College London, in 2001, where he received several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram completed specialist training in acute and general medicine in Oxford and subsequently held a Consultant appointment in Acute General Medicine at the John Radcliffe Hospital, Oxford. He also trained in anaesthesia and intensive care in London, including advanced training in regional anaesthesia and intensive care, and subsequently held a Consultant appointment in Intensive Care, Anaesthesia and Peri-operative Medicine at the Royal Free London Hospitals.

His postgraduate training has spanned internal medicine, anaesthesia, intensive care and point-of-care ultrasound (POCUS). He was awarded Fellowship of the Royal College of Anaesthetists in 2009, Fellowship of the Faculty of Intensive Care Medicine in 2013, and the European Diploma in Intensive Care Medicine in 2014. He is a Fellow of both the Royal College of Physicians of Edinburgh and the Royal College of Physicians of London.

Dr Rajendram is currently a Consultant at King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, and holds a joint appointment as Associate Professor in the Research Unit, Department of Medical Education, at King Saud bin Abdulaziz University for Health Sciences.

His multidisciplinary clinical background has informed his research interests in nutrition, fluid management and fluid balance in health and disease, particularly in acutely and critically ill patients. His research has also addressed POCUS, COVID-19 phenotypes and nutritional support in illness. Dr Rajendram has contributed extensively to medical research and education and has authored more than 400 textbook chapters, review articles, peer-reviewed papers and conference abstracts.

Affiliations and expertise
Consultant, Medical Protocol Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia & Joint Appointment Associate Professor, Research Unit, Department of Medical Education, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

VP

Victor R. Preedy

Victor R. Preedy, BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC, FRSM, is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He also holds an Honorary Professorship at the University of Suffolk and served as the long‑term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy graduated with an Honours Degree in Biology and Physiology with Pharmacology and later obtained his PhD from the University of London. He subsequently received Membership of the Royal College of Pathologists and later earned his second doctorate (DSc) in recognition of his contributions to protein metabolism. He is a Fellow of the Royal Society of Medicine, the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health and Hygiene, the Royal Society for Public Health, and the Royal Society of Chemistry. Professor Preedy has conducted research while affiliated with Imperial College London, the School of Pharmacy (now part of University College London), and the MRC Centre at Northwick Park Hospital. He has collaborated widely with international research groups in Finland, Japan, Australia, the USA, and Germany. His longstanding academic interests include health and well‑being. He has published more than 750 works, including peer‑reviewed research articles, abstracts, symposium presentations, reviews, and edited books.

Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK; Visiting Professor, University of Hull, UK

VP

Vinood B. Patel

Vinood B. Patel, BSc, PhD, FRSC, is Professor in Clinical Biochemistry at the University of Westminster. In 2014 Dr Patel was elected as a Fellow to The Royal Society of Chemistry. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School, NC, USA studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding mitochondrial oxidative stress. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to health and well being These books include Ancient and traditional foods, plants and herbs and spices in human health; coffee in health and disease prevention, Nuts and seeds in health and disease prevention Handbook of Substance Misuse and Addictions: From Biology to Public Health, tea in health and disease prevention.

Affiliations and expertise
Professor, Clinical Biochemistry, School of Life Sciences University of Westminster, London, UK

CM

Colin R. Martin

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.
Affiliations and expertise
Visiting Professor of Perinatal Wellbeing, Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

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