Transport Proteins
- 1st Edition, Volume 123 - January 21, 2021
- Editor: Rossen Donev
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 0 8 7 - 0
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 0 8 8 - 7
Transport Proteins, Volume 123, provides the latest information on the two major groups of transport proteins, those that carry molecules to different locations within a cell o… Read more
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Request a sales quoteTransport Proteins, Volume 123, provides the latest information on the two major groups of transport proteins, those that carry molecules to different locations within a cell or organism and those that carry molecules across otherwise impermeable membranes. Chapters in the updated release include Biology of Iron Transport: Ferroportin, Transport of transition metals across biological membranes, The effect of sport and physical activity on transport proteins: implications for cancer prevention and control, Structural rearrangement in polyketide synthase for improvement its bio-physicochemical properties, Autophagy Proteins and its Homeostasis in Cellular Environment, and much more.
- Integrates experimental and computational methods for studying the structure and function of transport proteins and their implication in drug design
- Contains timely chapters written by well-renowned authorities in their field
- Includes a high number of top quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and students
Protein chemists, molecular cell biologists, immunologists, structural biologists, computational biochemists, medical doctors, pharmacologists and other researchers working in the field of transport proteins and drug design. Articles published here would also be of a considerable benefit to medical, biology and pharmacology students specializing in this field
- Cover image
- Title page
- Table of Contents
- Advances in Protein Chemistry and Structural Biology
- Copyright
- Contributors
- Chapter One. Biology of the iron efflux transporter, ferroportin
- 1. Iron metabolism and the central role of ferroportin
- 2. Structure of ferroportin
- 3. Regulation of ferroportin
- 4. Disorders associated with ferroportin dysfunction
- 5. Ferroportin partners-molecules involved in efficient ferroportin functioning
- 6. Conclusion
- Chapter Two. The effect of sport and physical activity on transport proteins: implications for cancer prevention and control
- 1. Transport proteins
- 2. Muscles
- 3. Muscle and transport proteins
- 4. Sport and transport proteins: implications for cancer treatment and prevention
- 5. Conclusions
- Chapter Three. Cancer bioenergetics as emerging holistic cancer theory: the role of metabolic fluxes and transport proteins involved in metabolic pathways in the pathogenesis of malignancies. State-of-the-art and future prospects
- 1. Introduction
- 2. Cancer and bio-energetics: the emerging field of “onco-energetics”
- 3. Altered glycolysis and pyruvate oxidation metabolic fluxes in cancer
- 4. Altered glutamine metabolic fluxes in cancer
- 5. Altered serine metabolic fluxes in cancer
- 6. Altered TCA metabolism in cancer
- 7. Altered methionine metabolism in cancer
- 8. Altered tryptophan metabolism in cancer
- 9. Altered leucine metabolism in cancer
- 10. Altered ornithine metabolism in cancer
- 11. Altered proline metabolism in cancer
- 12. Altered acetate metabolism in cancer
- 13. Altered lipid metabolism in cancer
- 14. Mitochondrial structural and functional impairment
- 15. Tumor microenvironment
- 16. Nuclear DNA genes mutations
- 17. Cellular pathways mutations
- 18. Conclusions and future prospects
- Chapter Four. Investigating mutations at the hotspot position of the ERBB2 and screening for the novel lead compound to treat breast cancer – a computational approach
- 1. Introduction
- 2. Materials and methods
- 3. Results
- 4. Discussion
- 5. Conclusion
- Supplementary data
- Chapter Five. Autophagy proteins and its homeostasis in cellular environment
- 1. Introduction
- 2. Methodology
- 3. Results
- 4. Discussion
- Chapter Six. Expression of placental glucose transporter proteins in pregnancies complicated by fetal growth disorders
- 1. Introduction
- 2. Characteristics of GLUT proteins in human placenta
- 3. Placental glucose transport in pregnancies complicated by fetal macrosomia
- 4. Placental glucose transport in pregnancies complicated by fetal growth restriction
- 5. Placental GLUT-mediated interventions in pregnancies complicated by fetal growth disorders
- 6. Conclusions
- Chapter Seven. The role of transferrins and iron-related proteins in brain iron transport: applications to neurological diseases
- 1. Introduction
- 2. Brain iron transport
- 3. Iron and neurodegeneration
- 4. Iron transport related proteins
- 5. Transferrins
- 6. Perspectives on the use of transferrin as a drug delivery system
- 7. Concluding remarks
- Chapter Eight. ABCG: a new fold of ABC exporters and a whole new bag of riddles!
- 1. ABC transporters and their relevance
- 2. Structure of type I and type II exporters
- 3. Yeast ABCG/PDR transporters: contribution toward understanding the enigma of non-catalytic nucleotide-binding sites
- 4. Concluding thoughts and future perspectives
- Chapter Nine. Serum albumin: clinical significance of drug binding and development as drug delivery vehicle
- 1. Clinical implications of drug−serum albumin binding
- 2. HSA-based drug delivery systems
- Chapter Ten. PTR2/POT/NPF transporters: what makes them tick?
- 1. Introduction
- 2. A plethora of natural substrates
- 3. 3D-structure and transport mechanism
- Chapter Eleven. Network analysis of transcriptomics data for the prediction and prioritization of membrane-associated biomarkers for idiopathic pulmonary fibrosis (IPF) by bioinformatics approach
- 1. Introduction
- 2. Materials and methods
- 3. Results and discussion
- 4. Conclusion
- Supplementary data
- No. of pages: 286
- Language: English
- Edition: 1
- Volume: 123
- Published: January 21, 2021
- Imprint: Academic Press
- Hardback ISBN: 9780128220870
- eBook ISBN: 9780128220887
RD
Rossen Donev
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.
Affiliations and expertise
Head of Research, MicroPharm Limited, UKRead Transport Proteins on ScienceDirect