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Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 1, sets a new standard in transplant and regenerative medicine. The book details the-state… Read more
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Immediately download your ebook while waiting for your print delivery. No promo code needed.
Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 1, sets a new standard in transplant and regenerative medicine. The book details the-state-of-the-art in modern whole pancreas and islet transplantation, including donor selection, immunosuppression, complications, allograft pathology, and more. As regenerative medicine is changing the premise of solid organ transplantation, this volume catalogs the technologies being developed and the methods being implemented to bioengineer or regenerate the endocrine pancreas in order to more effectively treat diabetes. Edited and authored by unparalleled leaders in the field, this new volume argues for a much needed synergy between organ transplantation and regenerative medicine.
Transplant, regenerative medicine and diabetes investigators, basic scientists, biomedical engineers
PART A. WHOLE PANCREAS ALLO-TRANSPLANTATION
Section I. Introduction
1. History of Pancreas Transplantation
2. How to build a Pancreas Transplant Program
3. Pathophysiology of Diabetes
4. Epidemiology of Diabetes Mellitus
Section II. The Donor
5. Pancreas Donor Selection
6. Deceased Donor Pancreas Procurement
7. Surgical Techniques for Living Donor Pancreas Transplantation
8. Pancreas Preservation
9. Pancreas Graft Back-Table Surgery Technique
Section III. The Recipient
10. Pancreas Transplant Alone
11. Pancreas After Kidney Transplantation
12. Simultaneous Pancreas-Kidney Transplantation
13. Surgical Techniques for Deceased Donor Pancreas Transplantation
14. Robotic Pancreas Transplantation
15. Pancreas Transplantation in the setting of multivisceral transplantation
16. Imaging in pancreas transplantation
17. Post-Operative Care of the Pancreas Transplanted Patient
18. Immunosuppression for Pancreas Allo-Transplantation
Section IV. Complications after Pancreas Allo-Transplantation
19. Infectious Complications after Pancreas Allo-Transplantation
Paolo Antonio Grossi
20. Medical Complications after Pancreas Transplantation
21. Technical Complications of Pancreas Allo-Transplantation
22. Rejection After Pancreas Transplantation
Section V. Natural History
23. Reversal of Secondary Complications of Type 1 Diabetes (Nephropathy, Neuropathy, Retinopathy, and Cardiopathy)
24. Recurrence of Type 1 Diabetes following Simultaneous Pancreas-Kidney Transplantation
25. Pathological Evaluation of Whole Pancreas Transplants
26. Failure of the Pancreas Allograft
27. Pancreas Retransplantation
Section VI: State of the Art of Pancreas Transplantation
28. The Current State of Pancreas Transplantation in the USA – A Registry Report
29. Trends in Pancreas Transplantation in the United States
30. Experimental pancreas transplantation
31. Pancreas Transplantation: Current Issues, Unmet Needs and Future Perspectives
PART B. ISLET ALLO-TRANSPLANTATION
Section I. Introduction and Indications
32. Treatment of Type 1 Diabetes Complicated by Problematic Hypoglycemia
33. Eligibility of Patients with Type 1 Diabetes for Islet Transplantation Alone
34. Islet versus Pancreas Transplantation in Nonuremic Patients with Type 1 Diabetes
35. Simultaneous Islet-Kidney (SIK) and Islet After Kidney Transplantation (IAK)
36. Pancreatic islet transplantation in cystic fibrosis: lung and islet transplantation
37. Combined Liver and Islet Transplantation in Hepatogenous Diabetes, Cluster Exenteration and Cirrhosis with Type 1 Diabetes
Section II. Donor Selection
38. Evolving approaches to organ allocation for whole pancreas versus islet transplantation
39. Living donors
40. Pancreatic Islet Isolation from Donation After Circulatory Death Pancreas
Section III. Islet Isolation
41. Factors Related to Successful Clinical Islet Isolation
42. Pancreas and Islet Preservation
43. Collagenases in Pancreatic Islet Isolation
44. Predicting the Function of Islets after Transplantation
Section IV. Outcomes after Allogenic Pancreatic Islet
45. Metabolic and Endocrine Evaluation of Islet Transplant Function
46. Procedure-Related and Medical Complications In and After Intraportal Islet Transplantation
47. Secondary Complications of Diabetes
Section V. Current Clinical Results
48. Treating diabetes with islet transplantation: lessons learnt from the Nordic network for clinical islet transplantation
49. UK's nationally funded integrated islet transplant program
50. Type 1 Diabetes transplanted with allogenic islets within the Swiss-French GRAGIL Network
51. Primary graft function and long-term outcome of islet allotransplantation: the Lille experience
52. Treating diabetes with islet transplantation: Lessons from the Milan experience
53. Treating Diabetes with Islet Transplantation: Lessons from the University of Miami
54. Treating Diabetes with Islet Cell Transplantation: Lessons from the Edmonton Experience
Section VI. Monitoring of Allogeneic Islet Grafts
55. Immune monitoring of allogenic islets
56. Markers for Βeta Cell Loss
57. In Vivo Quality Control of Human Islets in the Immunodeficient Mouse to Predict Islet Function in Man: a retrospective study in 87 clinical transplants
Section VII. Immunomodulatory Technologies Applied to Islet Transplantation
58. Progress toward islet transplantation tolerance
59. Anti-inflammatory Strategies to Enhance Islet Engraftment and Survival
60. Islet Immunoisolation by Macroencapsulation
61. Islet Immunoisolation by Microencapsulation
62. Recurrence of Type 1 Diabetes After Beta Cell Replacement
Section VIII. Cellular Therapies in Preclinical and Clinical Islet Transplantation
63. T regulatory cell therapy in preclinical and clinical pancreatic islet transplantation
64. Cellular Therapies in Preclinical Clinical Islet Transplantation: Mesenchymal Stem Cells
65. Alternative transplantation sites for islet transplantation
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