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Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2, sets a new standard in transplant and regenerative medicine. The book details the state-of-… Read more
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Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2, sets a new standard in transplant and regenerative medicine. The book details the state-of-the-art in modern islet auto-transplantation, also discussing current progress in regenerative medicine research in diabetes medicine. Regenerative medicine is changing the premise of solid organ transplantation, hence this volume catalogs technologies being developed and methods being implemented. Bioengineering and regenerating beta cells, clinical pancreas and islet transplantation, tissue engineering, biomaterial sciences, stem cell biology and developmental biology are all addressed and applied directly to diabetes medicine.
Transplant, regenerative medicine and diabetes investigators, basic scientists, biomedical engineers
PART A. ISLET ALLO-TRANSPLANTATION
Section I. Chronic Pancreatitis
1. Etiopathogenesis and Pathophysiology of Chronic Pancreatitis
2. Non-Replacement Treatment of Chronic Pancreatitis: Conservative, Endoscopic and Surgical (Resection and Drainage Procedures)
Section II. Islet Auto-Transplantation for Chronic Pancreatitis
3. Requirements for clinical islet laboratories
4. Islet Isolation for Autotransplantation, following Total or Near Total Pancreatectomy
5. Strategies to improve islet yield from chronic pancreatitis pancreases intended for islet auto-transplantation
6. Surgical Techniques for Total Pancreatectomy and Islet Autotransplantation
7. Total Pancreatectomy with Islet Autotransplantation in Children
8. Islet Auto-Transplantation: Indication beyond Chronic Pancreatitis
Section III. Outcomes
9. Postoperative Care and Prevention and Treatment of Complications Following Total Pancreatectomy with Islet Cell Autotransplantation
10. Metabolic Outcomes after Total Pancreatectomy Followed by Islet Autotransplantation (TPIAT): Mixed Blessings
11. Long-term Results of TP/IAT
PART B. BIOENGINEERING AND REGENERATION OF THE ENDOCRINE PANCREAS
Section I. Pancreas Development and Regeneration
12. Embryonic Development of the Endocrine Pancreas
13. Human pancreatic progenitors
14. Strategies to Promote Beta Cell Replication and Regeneration
15. Diet as a therapeutic approach to diabetes management and pancreas regeneration
16. The Benefits of Metabolic/Bariatric Surgery on Diabetes Mellitus
Section II. Scaffolds for Endocrine Pancreas Bioengineering
17. ECM-Based Scaffolds for Pancreas Bioengineering
18. Plasma Scaffolds for Islet Transplantation
19. Biologic resorbable scaffold for tissue engineering the endocrine pancreas: Clinical experience of Islet Transplantation on the Omentum
20. Endothelialized Collagen Modules for Islet Tissue Engineering
Section III. Islet Encapsulation
21. Conformal Coating
22. Co-Encapsulation of ECM Proteins to Enhance Pancreatic Islet Cell Function
23. Co-encapsulation of mesenchymal stromal cells to enhance islet function
24. Silk-based Encapsulation Materials to Enhance Pancreatic Cell Functions
25. Cell Pouch Devices
Section IV. Stem Cells to Generate Insulin Producing Cells
26. Pancreas progenitors
27. Human embryonic stem cells (hESC) as a source of insulin producing cells
28. Human induced pluripotent stem cells (iPSC) as a source of insulin producing cells
29. Ductal cell reprograming to insulin-producing cells as a potential beta cell replacement source for islet auto-transplant recipients
30. Synthetic Biology Technologies for Beta Cell Generation
Section V. Animal-based Platforms for Pancreas Bioengineering
31. Xenotransplantation of the Endocrine Pancreas
32. Interspecies Blastocyst Complementation
Section VI. Tissue Engineering Technologies Applied to Beta Cell Replacement
33. Bioengineering, biomaterials and Beta Cell Replacement therapy
34. Subcutaneous islet transplantation using tissue-engineered sheets
Section VII. Regulation and Funding
35. Regulation for Regenerative Medicine Based Therapies
36. Catalyzing beta cell replacement research to achieve insulin independence in Type 1 Diabetes: Goals and Priorities
37. Regenerative Medicine Technologies Applied to Beta Cell Replacement: The Industry Perspective
Section VIII: Conclusive Remarks
38. Pancreas Whole Organ Engineering
39. Ethical Aspects of Transplantation, Bioengineering and Regeneration of the Endocrine Pancreas
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