Translational Cardiometabolic Genomic Medicine

1st Edition - September 7, 2015

Editor: Annabelle Rodriguez-Oquendo

Hardback ISBN:

9 7 8 - 0 - 1 2 - 7 9 9 9 6 1 - 6

eBook ISBN:

9 7 8 - 0 - 1 2 - 8 0 0 4 7 4 - 6

Translational Cardiometabolic Genomic Medicine, edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students,… Read more

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Translational Cardiometabolic Genomic Medicine

, edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases.

This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis.

It encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome to the use of molecular diagnostic testing in predicting increased risk of cardiovascular diseases. Where applicable, this reference also includes chapters related to therapeutic options specifically aligned to molecular targets.

Chapter 1. Metabolomics and Cardiovascular Medicine
- 1. Introduction
- 2. Metabolomic Methods
- 3. Metabolomic Data Analysis
- 4. Metabolomic Informatics Resources
- 5. Clinical and Population-Based Studies of Metabolomics and Cardiometabolic Conditions
- 6. Metabolomics and Genome-Wide Association Studies
- 7. Conclusions
Chapter 2. Modern Transcriptomics and Small RNA Diversity
- 1. Introduction
- 2. Small Non-coding RNAs
Chapter 3. A Systems-Level Understanding of Cardiovascular Disease through Networks
- 1. Introduction
- 2. What Is a Network?
- 3. Network Organizing Principles
- 4. Types of Networks
- 5. Integrating Genetics and Networks
- 6. Applications of Network-Based Systems Genetics Studies
- 7. Conclusions and Future Prospects
- List of Abbreviations
Chapter 4. Using Information about DNA Structure and Dynamics from Experiment and Simulation to Give Insight into Genome-Wide Association Studies
- 1. Introduction
- 2. The Structure and Characterization of DNA
- 3. DNA and Its Environment
- 4. Final Remarks
Chapter 5. Genomic Medicine and Lipid Metabolism: LDL Targets and Stem Cell Research Approaches
- 1. LDL Functions of the Hepatocyte
- 2. Human Single-Gene Genetic Disorders of LDL Metabolism
- 3. Recent Human Genomic Findings Related to LDL Dysfunction
- 4. Modeling Cholesterol Homeostasis Using In vitro Stem Cell Approaches
- 5. Using hiPSCs for Genetic Disease Modeling and Basic Personalized Medicine Research
- 6. Using Stem Cell-Derived Hepatocytes to Study Pharmacology
- 7. Future Directions
Chapter 6. Discovery of High-Density Lipoprotein Gene Targets from Classical Genetics to Genome-Wide Association Studies
- 1. Introduction
- 2. HDL-Modifying Genes Identified from Classic Genetic Disorders
- 3. HDL-Modifying Genes Identified from GWAS
- 4. Genes Previously Associated with Dyslipidemia and Lipid Metabolism
- 5. Genes Previously Associated with Diabetes and Obesity
- 6. Lipid Trafficking-Related Genes
- 7. Chromatin-Modifying Genes, Transcription Factors and RNA Processing Related Genes
- 8. Signal Transduction-Related Genes
- 9. Other GWAS-Identified HDL-Associated Genes
- 10. HDL-Modifying Genes Associated with CAD
- 11. Summary
Chapter 7. The Genetics of Obesity
- 1. Introduction
- 2. Leptin and Hypothalamic Control of Appetite and Energy Regulation
- 3. Monogenic Obesity
- 4. Common Obesity
- 5. The Missing Heritability
- 6. Gene–Environment Interaction Studies
- 7. Genetic Testing in Obesity
- 8. Conclusions
Chapter 8. The Epidemiology and Genetics of Vascular Dementia: Current Knowledge and Next Steps
- 1. Definition and Features of Vascular Dementia
- 2. Epidemiology of VaD
- 3. Genetics of VaD
- 4. Future of Genetic Studies
- 5. Summary
- Abbreviations
Chapter 9. Genomic Medicine and Ethnic Differences in Cardiovascular Disease Risk
- 1. Introduction
- 2. Methodological Issues with Cross-Cultural Research
- 3. The Impact of Ethnicity on the Epidemiology of Cardiovascular Disease
- 4. Ethnic Differences in CVD Risk Factors
- 5. Ethnic Differences in Biomarkers of CVD
- 6. The Role of the Genome
- 7. Impact of Personalized Genomics for CVD
- 8. Synthesis
Chapter 10. Genomics-Guided Immunotherapy of Human Epithelial Ovarian Cancer
- 1. Epithelial Ovarian Cancer from a Clinical Perspective: Current Treatments and Challenges
- 2. Immune Response to Ovarian Cancer
- 3. Next-Generation Sequencing and Its Application to Cancer Genomics
- 4. Analysis of Ovarian Cancer Samples in the TCGA Database
- 5. Implications for Genomics-Driven Immunotherapy of Human Ovarian Cancer
Chapter 11. Overview of the Intersection of Genomics of Cholesterol Metabolism and Cardiometabolic Disease with Reproductive Health, Especially in Women
- 1. Introduction
- 2. Cholesterol and Infertility
- 3. Cholesterol Metabolism
- 4. Genetic Alterations Affecting Cholesterol Uptake and Their Influence on Human Fertility
- 5. Genetic Alterations Affecting Cholesterol Mobilization and Their Influence on Human Fertility
- 6. Genetic Alterations Affecting De Novo Cholesterol Synthesis and Their Influence on Human Fertility and Embryonic Viability
- 7. The Genomics of Human Fertility Disorders
- 8. Polycystic Ovary Syndrome
- 9. Premature Ovarian Failure
- 10. Endometriosis
- 11. Conclusions
Chapter 12. Overview of Intersection of Genomics of Cardiometabolic Disease and Other Disease States, Such as Eye Health (Macular Degeneration)
- 1. Introduction
- 2. Characteristic AMD Lesions
- 3. The Genetics of AMD
- 4. Age, Oxidative Stress, and Reverse Cholesterol Transport
- 5. Apolipoprotein E
- 6. LIPC and CETP genes
- 7. Nutritional Influences
- 8. Inflammation and the Complement Pathway
- 9. Angiogenesis
- 10. Conclusion
Chapter 13. Translating Genomic Research to the Marketplace
- 1. Introduction
- 2. The Cardiovascular Genomics Marketplace
- 3. Initial Considerations in Commercializing Research
- 4. Commercialization Model
- 5. Intellectual Property
- 6. Product Development: Developing a Biomarker or Companion Diagnostic
- 7. Regulatory Considerations
- 8. Marketing and Sales Development
- 9. Concluding Discussion
Index