Translating Regenerative Medicine to the Clinic

1st Edition - November 18, 2015
Imprint: Academic Press
Editors: Jeffrey Laurence, Pedro Baptista, Anthony Atala
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 0 0 5 4 8 - 4
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 0 0 5 5 2 - 1

Translating Regenerative Medicine to the Clinic reviews the current methodological tools and experimental approaches used by leading translational researchers, discussin… Read more

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Translating Regenerative Medicine to the Clinic
reviews the current methodological tools and experimental approaches used by leading translational researchers, discussing the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration, and regeneration of the bone and skin.

Pedagogically, the book concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasizing recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole.

Volumes in the series include Translating Gene Therapy to the Clinic, Translating Regenerative Medicine to the Clinic, Translating MicroRNAs to the Clinic, Translating Biomarkers to the Clinic, and Translating Epigenetics to the Clinic.

Contributors
Part I. Introduction
- Chapter 1. Regenerative Medicine: The Hurdles and Hopes
  - 1. Introduction
  - 2. On the Origins of Regenerative Medicine
  - 3. From Cells and Scaffolds to Tissues and Organs
  - 4. Biomaterials, Tissue and Organ Bioengineering
  - 5. Gene Therapy
  - 6. Stem Cell Therapies
  - 7. Future Directions
Part II. Biomaterials and Tissue/Organ Bioengineering
- Chapter 2. Extracellular Matrix as an Inductive Scaffold for Functional Tissue Reconstruction
  - 1. Introduction
  - 2. ECM as a Scaffold for Regenerative Medicine
  - 3. Decellularization and Fabrication Methods
  - 4. Translational Applications of ECM in Regenerative Medicine
  - 5. Mechanisms of Constructive Remodeling
  - 6. Conclusions
- Chapter 3. Whole-Organ Bioengineering—Current Tales of Modern Alchemy
  - 1. Introduction
  - 2. Current Status of Organ Transplantation
  - 3. Current Status on Organ Bioengineering
  - 4. Current Applications for Bioengineered Organs
  - 5. Current Limitations
  - 6. Conclusions
- Chapter 4. Regenerative Implants for Cardiovascular Tissue Engineering
  - 1. Introduction
  - 2. Types of Regenerative Implants—The Continuity Bridge
  - 3. Function of Implants
  - 4. Clinical Applications in Cardiovascular Repair
  - 5. Conclusion
- Chapter 5. Tissue Engineering and Regenerative Medicine: Gastrointestinal Application
  - 1. The Gastrointestinal Tract: Overview
  - 2. Neurodegenerative Diseases of the GI Tract
  - 3. Cell Source in Regenerating the Neuromusculature of the GI Tract
  - 4. Scaffolds as Support for Neuromusculature Regeneration
  - 5. Tissue Engineering of Different Parts of the GI Tract: Current Concepts
  - 6. Conclusion
- Chapter 6. Injury and Repair of Tendon, Ligament, and Meniscus
  - 1. Introduction
  - 2. Prevalent Injuries of Tendon, Ligament, and Meniscus
  - 3. Tendon, Ligament, and Meniscus Injuries and Joint Function
  - 4. Current Clinical Interventions
  - 5. Tissue Engineering and Regenerative Therapeutic Approaches for Injuries of Tendon, Ligament, and Meniscus
  - 6. Conclusions and Future Directions
- Chapter 7. Cartilage and Bone Regeneration—How Close Are We to Bedside?
  - 1. Introduction
  - 2. Concepts and Treatment Strategies
  - 3. Biomaterials for Bone and Cartilage Regeneration
  - 4. Bone and Cartilage Tissue Engineering
  - 5. Clinical Trials
  - 6. Commercial Products
  - 7. Conclusions and Future Directions
- Chapter 8. Current Applications for Bioengineered Skin
  - 1. Introduction
  - 2. Skin Regenerative Medicine
  - 3. Bioengineered Skin Systems
  - 4. Challenges and Future Directions
  - 5. Conclusions
- Chapter 9. Urologic Tissue Engineering and Regeneration
  - 1. Introduction
  - 2. Cells for Implantation
  - 3. Biodegradable Biomaterials
  - 4. Applications in Urinary Tract System
  - 5. Future Directions
  - 6. Conclusion
- Chapter 10. Regenerative Medicine and Tissue Engineering in Reproductive Medicine: Future Clinical Applications in Human Infertility
  - 1. Introduction
  - 2. Cell Therapy Approaches/Stem Cell Technology in Reproductive Medicine
  - 3. Tissue Engineering in Reproductive Medicine
  - 4. Conclusions and Future Directions
Part III. Gene Therapy and Molecular Medicine
- Chapter 11. Viral and Nonviral Vectors for In Vivo and Ex Vivo Gene Therapies
  - 1. Viral Vectors
  - 2. Nonviral Vectors for Gene Therapy
  - 3. Exosomes as Biological Vehicles
  - 4. Clinical Applications
  - 5. Conclusions and Future Directions
- Chapter 12. Treating Hemophilia by Gene Therapy
  - 1. Rationale for Gene Therapy
  - 2. Hemophilia: Pathophysiology, History, and Clinical Management
  - 3. Preclinical Testing of Gene Therapy for Hemophilia
  - 4. Using Cells as Vehicles to Deliver Factors VIII and IX to Treat Hemophilia
  - 5. Human Clinical Gene Therapy Trials for Hemophilia
  - 6. Future Directions in Gene Therapy for Hemophilia
  - 7. Conclusions
- Chapter 13. Gene Therapy in Monogenic Congenital Myopathies
  - 1. Introduction to Monogenic Congenital Myopathies
  - 2. Gene Therapy
  - 3. Vector Toolbox
  - 4. Routes of Delivery
  - 5. Preclinical Disease Model Systems
- Chapter 14. Microvesicles as Mediators of Tissue Regeneration
  - 1. Introduction
  - 2. Functions of MVs
  - 3. Mesenchymal Stem Cells and Regenerative Medicine
  - 4. MSC-MVs in Kidney Regeneration
  - 5. MSC-MVs in Cardiac Regeneration
  - 6. MVs in Regeneration of Other Tissues
  - 7. MVs and Embryonic Stem Cells
  - 8. Future Perspectives
Part IV. Cell Therapies and Other Applications
- Chapter 15. Nature or Nurture: Innate versus Cultured Mesenchymal Stem Cells for Tissue Regeneration
  - 1. Introduction
  - 2. The Conventional Cultured MSC: A Brief Historic Perspective
  - 3. Medical Use of MSCs
  - 4. The Original Tissue Resident MSC: A Better Therapeutic Alternative?
  - 5. Perspectives
- Chapter 16. Adipose Tissue as a Plentiful Source of Stem Cells for Regenerative Medicine Therapies
  - 1. Therapeutic Potential of Adipose-Derived Stem Cells
  - 2. Lipoharvest Methods
  - 3. Methods of SVF Isolation: Automated versus Manual
  - 4. Flow Cytometry Analysis
  - 5. Regulatory Process
  - 6. Current Clinical Trials and Growing Possibilities
  - 7. Concluding Remarks
- Chapter 17. Developing “Smart” Point-of-Care Diagnostic Tools for “Next-Generation” Wound Care
  - 1. Introduction
  - 2. Pathogenesis of Chronic Wounds
  - 3. Chronic Wound Care
  - 4. Biomarkers: Molecular “Bar Coding” of Chronic Wounds
  - 5. Novel Devices for Wound Assessment
  - 6. Summary and Future Outlook
- Chapter 18. Cell Therapy for Cardiac Regeneration
  - 1. Introduction
  - 2. Concepts and Strategies of Cardiac Regeneration
  - 3. The Search for the Ideal Cell: Extracardiac Sources
  - 4. Heart-Resident Stem and Progenitor Cells
  - 5. Pluripotent Stem Cells
  - 6. Direct Reprogramming of Nonmyocytes
  - 7. Unresolved Issues and Future Perspectives
- Chapter 19. Cord Blood Transplantation in Hematological and Metabolic Diseases
  - 1. Umbilical CB Banking
  - 2. Overview of Banking Technology
  - 3. Early Transplant Experience with Umbilical CBT
  - 4. Umbilical CBT in Pediatrics
  - 5. Umbilical CBT in Adults
  - 6. HSCT as a Treatment for IMDs
  - 7. Umbilical CBT in the Mucopolysaccharidoses
  - 8. Umbilical CBT in the Leukodystrophies
  - 9. Investigations in the Treatment of Acquired Brain Injuries with Umbilical CB
  - 10. Summary
- Chapter 20. Mobilizing Endogenous Stem Cells for Retinal Repair
  - 1. Introduction
  - 2. Sources of Endogenous Stem/Progenitor Cells
  - 3. Niche Signals and Stem Cell Potential
  - 4. Intracellular Signals and Transcriptional Regulation
  - 5. Epigenetic Regulation of Stem Cell Potential
  - 6. Functional Restoration of Retinal Neurons
  - 7. Conclusions and Future Directions
- Chapter 21. Experimental Cell Therapy for Liver Dysfunction
  - 1. Introduction
  - 2. Human Hepatocytes
  - 3. Alternative Cell Sources
  - 4. Machine Perfusion for Liver Preservation
  - 5. Monitoring Cell Engraftment
  - 6. Conclusion
- Chapter 22. Microfluidic-Based 3D Models of Renal Function for Clinically Oriented Research
  - 1. Introduction
  - 2. Cell Sources for In vitro Kidney Models
  - 3. Modeling Renal Tubules Complex 3D Interactions
  - 4. Renal Organotypic Culture in Microfluidic Devices
  - 5. Current Limitations and Future Directions in In vitro Kidney Research
  - Glossary
Index

Jeffrey Laurence

Dr Laurence is pursuing the pathophysiology of cardiovascular and skeletal abnormalities linked to HIV disease and its therapies at Weill Cornell. Dr Laurence is the editor-in-chief of Translational Medicine, which Elsevier co-publishes with the CSCTR.

Affiliations and expertise

Weill Cornell Medical College, New York, NY, USA

Pedro Baptista

Pedro Baptista, PharmD, PhD, Marie Curie Alumni, is a Senior ARAID Researcher at IIS Aragon, Zaragoza, Spain, where he directs the Laboratory of Organ Bioengineering and Regenerative Medicine. He serves as a Visiting Professor of Biomedical Engineering at Universidad Carlos III de Madrid. Dr. Baptista earned his Pharmacy Degree from the University of Lisbon and completed his PhD training at the Wake Forest Institute for Regenerative Medicine in Winston-Salem, NC, USA. He is Secretary General of the European Society of Artificial Organs (ESAO) and Chair of the European Association for the Study of the Liver (EASL) Regenerative Hepatology Consortium. Dr. Baptista has published extensively in high-impact journals on organ bioengineering, organoids, and regenerative hepatology, holds four patents, and has successfully spun off several related technologies into companies.

Affiliations and expertise

Group Leader and Visiting Professor, Health Research Institute of Aragon, Zaragoza, Spain, and Carlos III University, Madrid, Spain

Anthony Atala

Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine, and the W. Boyce Professor and Chair of Urology. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. Fifteen applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is Editor of 25 books and 3 journals. Dr. Atala has published over 800 journal articles and has received over 250 national and international patents. Dr. Atala was elected to the Institute of Medicine of the National Academies of Sciences, to the National Academy of Inventors as a Charter Fellow, and to the American Institute for Medical and Biological Engineering. Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute’s Advisory Board. He is a founding member of the Tissue Engineering Society, Regenerative Medicine Foundation, Regenerative Medicine Manufacturing Innovation Consortium, Regenerative Medicine Development Organization, and Regenerative Medicine Manufacturing Society.

Affiliations and expertise

G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine; W. Boyce Professor and Chair, Department of Urology, and G. Link Professor and Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University. Winston Salem, North Carolina, USA

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Translating Regenerative Medicine to the Clinic

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Jeffrey Laurence

Pedro Baptista

Anthony Atala

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