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Transfusion Medicine and Hemostasis
Clinical and Laboratory Aspects
- 1st Edition - June 9, 2009
- Editors: Beth H. Shaz, Christopher D. Hillyer, James C. Zimring, Thomas C. Abshire
- Language: English
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 9 2 2 3 0 - 0
Transfusion Medicine and Hemostasis is a manual-style book that links transfusion medicine and hemostasis to laboratory methods and diagnostic tests engaged in routine and… Read more
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Request a sales quoteTransfusion Medicine and Hemostasis is a manual-style book that links transfusion medicine and hemostasis to laboratory methods and diagnostic tests engaged in routine and specialized coagulation laboratories. The book is divided into two main parts with chapters that are brief and readable. The first main part of the book is subdivided into blood banking and transfusion medicine. Under blood banking, the chapters cover blood collection, donation process, component manufacturing, donor testing and storage; transfusion-medicine chapters examine the components for transfusion, pre-transfusion immunohematology testing, blood groups, blood products and their modifications, approaches to transfusion therapy in specific clinical settings, and transfusion reactions and complications. In addition, chapters that talk about apheresis, cellular therapy, and tissue banking in the hospital setting are included. Hemostasis, the second main part of the book, is subdivided into three sections. The first section, clinical coagulation, includes chapters about neonatal thrombocytopenia, inherited platelet function disorders, immune thrombocytopenia, immune-mediated coagulopathies, congenital bleeding disorders, and acquired bleeding disorders. The second section relates to laboratory testing of coagulation, with chapters about laboratory assessments of platelet disorders, von Willebrand disease, coagulation factor disorders, fibrinogen and fibrinolysis, tests for hypercoagulable state and for activation of the coagulation system, and laboratory support for anticoagulation. The third section discusses coagulation factor products. This book will be valuable for the education of trainees, practitioners, and future leaders in these fields.
Residents and fellows in hematology, transfusion medicine, pathology, and anesthesiology; practicing physicians in hematology, transfusion medicine, pathology, and anesthesiology.
About the EditorsContributorsPrefaceAcknowledgmentsPart I. Blood Banking and Transfusion Medicine Introduction 1 Blood Banking and Transfusion Medicine – the Field, the Discipline and the Industry 2 Brief History of Blood Transfusion 3 Introduction to Quality Systems and Quality Management 4 The Role of the Physician in the Blood Center Donation Process 5 The Blood Donor, Donation Process and Technical Aspects of Blood Collection 6 Apheresis Blood Component Collections 7 Recipient-specific Blood Donations 8 Adverse Donor Reactions Component Manufacturing 9 Component Preparation and Manufacturing Donor Testing 10 Serologic Testing of Donor Products 11 Overview of Infectious Disease Testing 12 HIV Screening of Donor Products 13 Hepatitis B Screening of Donor Products 14 Hepatitis C Screening of Donor Products 15 West Nile Virus Screening of Donor Products 16 Syphilis, HTLV and Chagas Testing of Donor Products 17 Bacterial Detection Methods Transfusion Medicine 18 The Role of the Transfusion Service Physician Testing 19 Pretransfusion Testing 20 Antibody Identification 21 Direct Antiglobulin Test Blood Groups 22 ABO and H Blood Group Systems 23 Rh Blood Group System 24 Kell and Kidd Blood Group Systems 25 MNS and Duffy Blood Group Systems 26 Lewis, I and P Blood Group Systems 27 Other Blood Group Systems, Collections and Antigens Blood Products 28 Red Blood Cells and Related Products 29 Plasma Products 30 Platelet Products 31 Cryoprecipitate 32 Granulocyte Products 33 Albumin and Related Products 34 Human Immunoglobulin Preparations 35 Rh Immune Globulin Product Modifications 36 Irradiation of Blood Products 37 Leukoreduction of Blood Products 38 CMV-safe Blood Products 39 Frozen Blood Products 40 Washed Blood Products 41 Volume-reduced Products Specific Clinical Settings 42 Neonatal and Pediatric Transfusion Medicine 43 Perinatal Transfusion Medicine 44 Autoimmune Hemolytic Anemias 45 Transfusion Management in Patients with Hemoglobinopathies 46 Transfusion of Patients Undergoing HPC and Solid-organ Transplantation 47 Transfusion of HIV-positive Patients 48 Management of Patients Who Refuse Blood Transfusion 49 Platelet Transfusion Refractory Patients 50 Massive Transfusion 51 Perioperative Blood Management Transfusion Reactions 52 Adverse Events and Outcomes Following Transfusion: an Overview 53 Febrile Non-hemolytic Transfusion Reactions 54 Allergic, Anaphylactoid and Anaphylactic Reactions 55 Acute Hemolytic Transfusion Reactions 56 Delayed Hemolytic Transfusion Reactions 57 Transfusion-Associated Circulatory Overload 58 Transfusion-Related Acute Lung Injury 59 Septic Transfusion Reactions 60 Metabolic, Hypotensive and Other Acute Reactions and Complications 61 Posttransfusion Purpura 62 Transfusion Associated Graft versus Host Disease 63 Microchimerism 64 Transfusion Related Immunomodulation 65 Iron Overload 66 Transfusion Transmitted Diseases Therapeutic Apheresis and Phlebotomy 67 Overview of Therapeutic Apheresis 68 Therapeutic Plasma Exchange 69 Therapeutic Erythrocytapheresis 70 Therapeutic Thrombocytapheresis 71 Therapeutic Leukapheresis 72 Extracorporeal Photopheresis 73 LDL Pheresis 74 Immunoadsorption 75 Therapeutic Phlebotomy Cellular Therapy and Tissue Banking 76 HPC Products 77 Tissue Banking in the Hospital SettingPart II. Coagulation Introduction 78 Overview of the Coagulation System Clinical Coagulation 79 Approach to the Bleeding Patient Neonatal Thrombocytopenia 80 Congenital Thrombocytopenia 81 Neonatal Alloimmune Thrombocytopenia 82 Acquired Neonatal Thrombocytopenia Inherited Platelet Function Disorders 83 Bernard-Soulier Syndrome and Other GPIb-IX-V Related Receptor Defects 84 Glanzmann Thrombasthenia 85 Platelet Storage-granule Defects 86 Failure to Release and Aspirin-like Defects Immune Thrombocytopenia 87 Acute (Childhood) Immune Thrombocytopenic Purpura 88 Chronic Immune Thrombocytopenic Purpura 89 Drug-induced Thrombocytopenia 90 Heparin-induced Thrombocytopenia 91 Autoimmune Lymphoproliferative Syndrome Immune-mediated Coagulopathies 92 Hemolytic Uremic Syndrome 93 Thrombotic Thrombocytopenic Purpura 94 Antiphospholipid Antibody Syndrome Congenital Bleeding Disorders 95 von Willebrand Disease 96 Hemophilia A 97 Hemophilia B 98 Congenital Disorders of Fibrinogen 99 Factor XIII, α2 -Antiplasmin and Plasminogen Activator Inhibitor-1 Deficiencies 100 Factor XI Deficiency 101 Factor VII Deficiency 102 Factor II, Factor V and Factor X Deficiencies Acquired Bleeding Disorders 103 Bleeding Disorders in Pregnancy 104 Vascular Bleeding Disorders 105 Bleeding Risks with Liver Disease 106 Bleeding Risks with Vitamin K Deficiency 107 Bleeding Risks with Cardiac Disease 108 Bleeding Risks with Renal Disease 109 Bleeding Risks in Cancer 110 Disseminated Intravascular Coagulopathy 111 Acquired Coagulation Factor Inhibitors Laboratory Testing of Coagulation Introduction Screening Tests Laboratory Assessment of Platelet Disorders Laboratory Assessment of VWD Laboratory Assessment of Coagulation Factor Disorders Laboratory Assessment of Fibrinogen and Fibrinolysis Tests for Hypercoagulable State Tests for Activation of the Coagulation System Laboratory Support for Anticoagulation Coagulation Factor ConcentratesGeneral Handbook ReferencesIndex
- No. of pages: 775
- Language: English
- Edition: 1
- Published: June 9, 2009
- Imprint: Elsevier Science
- eBook ISBN: 9780080922300
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Beth H. Shaz
Beth H. Shaz, MD, is Chief Medical and Scientific Officer, Executive Vice President at New York Blood Center, and Adjunct Assistant Professor, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University. Beth is responsible for all medical and scientific activities throughout the NYBC network, which includes Rhode Island Blood Center, Innovative Blood Resources (Memorial Blood Center and Nebraska Blood Center), Community Blood Center of Greater Kansas City, and Blood Bank of Delmarva. Medical activities comprise of hemophilia services, clinical apheresis services, perioperative autologous transfusion services, cellular therapy, medical education, medical consultation, transfusion services, bone marrow donor recruitment, and donor management. Scientific activities include basic science at the Lindsey F. Kimball Research Institute and Comprehensive Cell Solutions (CCS), which contains translational and clinical research. NYBC’s scientific and medical activities focus on transfusion medicine, cell therapy, regenerative medicine, infectious disease, hematology, and personalized medicine. Beth is an editor of ten books in transfusion medicine, author of over 130 articles pertaining to transfusion medicine. She is an associate editor of TRANSFUSION and on the editorial board of BLOOD. Previously, she was an Associate Professor at Emory University School of Medicine and director of the transfusion service at Grady Memorial Hospital. Also, she was an instructor at Harvard Medical School and associate director of the transfusion service at Beth Israel Deaconess Medical Center in Boston. Beth received her MD with research distinction from the University of Michigan and BS in chemical engineering with distinction from Cornell University. She completed a general surgery internship at Georgetown University, an anatomic & clinical pathology residency at Beth Israel Deaconess Medical Center, and a transfusion medicine fellowship at Harvard Medical School.
Affiliations and expertise
Chief Medical and Scientific Officer and Executive Vice President, New York Blood Center and Adjunct Assistant Professor, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USACH
Christopher D. Hillyer
Christopher D. Hillyer, MD, is President and CEO of New York Blood Center and Professor, Department of Medicine, Weill Cornell Medical College, New York, NY. Previously, he was the tenured, endowed Distinguished Service Professor, Department of Pathology and Laboratory Medicine, Emory University School of Medicine and served as director of the Emory Center for Transfusion and Cellular Therapies with responsibility for all aspects of clinical and academic transfusion medicine at Emory’s seven principle hospitals. Dr. Hillyer is an editor of twelve textbooks in transfusion medicine, author of over 160 articles pertaining to transfusion, human immunodeficiency virus, and herpes viruses, most notably cytomegalovirus. Nationally recognized as an expert in hematology and blood transfusion, Dr. Hillyer is also a past-president, board of directors of AABB and a former trustee of the National Blood Foundation. Dr. Hillyer has been awarded many million dollars in research funding from the National Institutes of Health, the Centers for Disease Control and Prevention and other agencies. He was an associate editor of Transfusion and serves on several other editorial boards. Dr. Hillyer was formally recognized for his work in Africa as part of the AABB/Emory cooperative agreement from the President’s Emergency Plan For AIDS Relief (PEPFAR), and is a recipient of two Tiffany Awards from the American Red Cross where he also served as a medical director and a member of their national Medical Advisory Board. He also received the 2014 Emily Cooley Award from AABB for his “significant commitment and contributions to the field of transfusion medicine through extensive teaching, mentoring and professional leadership, and the countless clinical, scientific and innovative resource materials he has created to educate others”. He is a co-founder of Transfusion & Transplantation Technologies, Inc (3Ti) and holds over 20 patents or patents pending. Dr. Hillyer is board certified in transfusion medicine, hematology, medical oncology and internal medicine. He received his BS from Trinity College, and his MD from the University of Rochester School of Medicine, with postgraduate training and fellowships in hematology-oncology, transfusion medicine and bone marrow transplantation at Tufts-New England Medical Center.
Affiliations and expertise
President and Chief Executive Officer, New York Blood Center and Professor, Department of Medicine, Weill Cornell Medical College, New York, NY, USAJZ
James C. Zimring
Affiliations and expertise
Assistant Professor, Department of Pathology and Laboratory Medicine, Emory University School of Medicine; Associate Director, Emory University Special Hemostasis Laboratory, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USATA
Thomas C. Abshire
Affiliations and expertise
Professor, Department of Pediatrics, Emory University School of Medicine; Director, Special Coagulation Laboratory, Children’s Healthcare of Atlanta; Director’s Chair in Hemostasis, Hemophilia of Georgia, Inc., USARead Transfusion Medicine and Hemostasis on ScienceDirect