Tissue Engineering Using Ceramics and Polymers

3rd Edition - October 27, 2021

Editors: Aldo R. Boccaccini, P.X. Ma, Liliana Liverani

Paperback ISBN:

9 7 8 - 0 - 1 2 - 8 2 0 5 0 8 - 2

eBook ISBN:

9 7 8 - 0 - 1 2 - 8 2 0 5 7 9 - 2

Tissue Engineering Using Ceramics and Polymers, Third Edition is a valuable reference tool for both academic researchers and scientists involved in biomaterials or tissue… Read more

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Tissue Engineering Using Ceramics and Polymers, Third Edition is a valuable reference tool for both academic researchers and scientists involved in biomaterials or tissue engineering, including the areas of bone and soft-tissue reconstruction, repair and organ regeneration. With its distinguished editors and international team of contributors, this book reviews the latest research and advances in this thriving area and how they can be used to develop treatments for disease states. New sections cover nanobiomaterials, drug delivery, advanced imaging and MRI for tissue engineering, and characterization of vascularized scaffolds.

Technology and research in the field of tissue engineering has drastically increased within the last few years to the extent that almost every tissue and organ of the human body could potentially be regenerated with the aid of biomaterials.

Cover image
Title page
Table of Contents
Copyright
Contributors
About the editors
Foreword
Preface
References
Part I: General issues: Materials
Chapter 1: Ceramic biomaterials for tissue engineering
Abstract
1.1: Introduction
1.2: Bioceramics
1.3: Substitutions of hydroxyapatite
1.4: Bioactive ceramic composites
1.5: Properties of ceramics
1.6: Processing of ceramics
1.7: Characterization techniques
1.8: Conclusions and future trends
References
Further reading
Chapter 2: Synthetic polymeric biomaterials for tissue engineering
Abstract
2.1: Introduction
2.2: Synthetic polymeric scaffolds for tissue engineering
2.3: Polymeric scaffolds with controlled release capacity
2.4: Conclusions and future trends
References
Chapter 3: Natural polymeric biomaterials for tissue engineering
Abstract
Acknowledgments
3.1: Introduction
3.2: Natural biopolymers
3.3: Natural biopolymers-based scaffolding strategies for tissue engineering/regeneration
3.4: Conclusions and future trends
References
Further reading
Chapter 4: Bioactive glasses and ceramics for tissue engineering
Abstract
4.1: Introduction
4.2: From ceramic and glass monoliths to scaffolds for tissue engineering
4.3: Bioactive ceramics
4.4: Properties of bioactive ceramics
4.5: Tissue engineering applications of bioactive ceramics
4.6: Bioactive glasses
4.7: Preparation and properties of bioactive glasses
4.8: Bioactive glasses in tissue engineering
4.9: Bioactive glass − ceramics
4.10: Bioactive composites
4.11: Conclusions and future trends
References
Chapter 5: Biodegradable and bioactive polymer/inorganic phase composites
Abstract
5.1: Introduction
5.2: Tuning of biomaterial properties in composites
5.3: From micro to nano: How the scale influences material properties
5.4: Composite processing
5.5: Applications of composites in tissue engineering
5.6: Conclusions and future trends
References
Part II: General issues: Processing and characterization
Chapter 6: Overview of scaffolds processing technologies
Abstract
6.1: Introduction
6.2: Conventional technologies
6.3: Additive manufacturing
6.4: Conclusions and future trends
References
Chapter 7: Transplantation of engineered cells and tissues
Abstract
Acknowledgements
7.1: Introduction
7.2: Lack of rejection of tissue engineered products
7.3: Testing and regulatory consequences
7.4: Generality of the resistance of tissue-engineered products to immune rejection
7.5: Manufacturing consequences
7.6: Conclusions and future directions
7.7: Discussion of the literature
References
Chapter 8: Advanced imaging/MRI for tissue engineering
Abstract
8.1: Introduction
8.2: MRI techniques
8.3: MRI in tissue engineering
8.4: Advanced non-MRI techniques
8.5: Conclusions and future trends
References
Chapter 9: Nanoscale design in biomineralization for developing new biomaterials
Abstract
9.1: Introduction
9.2: Bone
9.3: Bone tissue engineering
9.4: Biomineralization
9.5: Silica-based nanoparticles
9.6: Nanocomposites
9.7: Conclusions and future trends
References
Chapter 10: Additive manufacturing of polymers and ceramics for tissue engineering applications
Abstract
10.1: Introduction
10.2: Additive manufacturing technologies
10.3: Additive manufacturing of polymers
10.4: Additive manufacturing of ceramics
10.5: Additive manufacturing of polymer-ceramic composites
10.6: Bioprinting
10.7: Conclusions and future trends
References
Part III: Tissue and organ regeneration
Chapter 11: Myocardial tissue engineering
Abstract
Acknowledgments
11.1: Introduction
11.2: Cells used in MTE
11.3: Scaffolds in MTE
11.4: Biomaterials used in MTE
11.5: Conclusions and future trends
References
Further reading
Chapter 12: Bladder tissue regeneration
Abstract
12.1: Introduction
12.2: Bladder reconstruction approaches using cells, biomaterials and tissue engineering
12.3: Review of bladder tissue engineering studies
12.4: Conclusions and future trends
References
Chapter 13: Peripheral nerve tissue engineering
Abstract
Acknowledgements
13.1: Overview of the nervous system
13.2: Peripheral nerves
13.3: Nerve injury and axon regeneration
13.4: Peripheral nerve gap repair—The gold standard
13.5: Nerve conduits (NCs)
13.6: Materials for NCs
13.7: Fabrication of NCs
13.8: Structural modifications of NCs
13.9: Cells for nerve repair
13.10: Cell-derived factors for regeneration
13.11: Conclusions and future trends
References
Chapter 14: Skeletal muscle tissue engineering
Abstract
14.1: Introduction
14.2: Skeletal muscle anatomy
14.3: Tissue engineering of skeletal muscle
14.4: 3-D matrices for skeletal muscle tissue engineering
14.5: Polymeric materials for electrospun nanofibers
14.6: Mechanical and electrical stimulation of engineered skeletal muscle
14.7: Vascularization and in vivo generation of 3-D muscle tissue
14.8: Conclusions and future trends
References
Chapter 15: Cartilage tissue engineering
Abstract
15.1: Introduction
15.2: Relevance of articular cartilage repair
15.3: Biology of articular cartilage
15.4: Repair of articular cartilage
15.5: Scaffold-based strategies for cartilage repair
15.6: Conclusions and future trends
References
Chapter 16: Bone tissue engineering
Abstract
Acknowledgments
16.1: Introduction
16.2: Bone tissue engineering: Native bone properties
16.3: Bone tissue engineering: Design considerations
16.4: Bone tissue engineering: Material approaches
16.5: Bone tissue engineering: Pre-clinical translation
16.6: Conclusions and future trends
References
Chapter 17: Nanofibrous scaffolds for skin tissue engineering and wound healing applications
Abstract
Acknowledgments
17.1: Introduction
17.2: Electrospinning as a constantly evolving technique for tissue engineering
17.3: Electrospun scaffolds for skin tissue regeneration
17.4: Electrospun scaffolds for wound healing
17.5: Conclusions and future trends
References
Chapter 18: Interface tissue engineering
Abstract
18.1: Introduction
18.2: Heterotypic interfaces: Ligament-to-bone
18.3: Heterotypic interfaces: Tendon-to-bone
18.4: Heterotypic interfaces: Cartilage-to-bone
18.5: Homotypic interfaces: Cartilage-to-cartilage
18.6: Conclusions and future trends
References
Chapter 19: Bioceramic nanoparticles in tissue engineering and drug delivery
Abstract
19.1: Introduction
19.2: Ceramic nanoparticles
19.3: Nanoparticles for drug delivery
19.4: Nanoparticles for gene transfer (transfection)
19.5: Nanoparticles for gene silencing
19.6: Fluorescent nanoparticles for imaging
19.7: Nanoparticles in tissue engineering
19.8: Conclusions and future trends
References
Chapter 20: Natural hydrogels for bone tissue engineering
Abstract
20.1: Introduction
20.2: Biological cues mimicking the osteogenic niche
20.3: Natural hydrogel materials
20.4: Conclusion and future trends
References
Chapter 21: Dense collagen-based scaffolds for soft tissue engineering applications
Abstract
21.1: Introduction
21.2: Collagen for tissue engineering
21.3: Dense collagen for soft tissue engineering
21.4: Potential in ligament and tendon tissue engineering applications
21.5: Conclusions and future trends
References
Chapter 22: Female reproductive organs tissue engineering
Abstract
22.1: Introduction
22.2: Fertility preservation treatments: State-of-the art
22.3: Uterus
22.4: Ovary
22.5: Fallopian tubes
22.6: Placenta
22.7: Conclusions and future trends
References
Chapter 23: Scaffolds with drug delivery capability
Abstract
23.1: Introduction
23.2: Composite scaffolds for bone tissue engineering
23.3: Conclusions and future trends
References
Index

Aldo R. Boccaccini

Aldo R. Boccaccini is Professor of Biomaterials and Head of the Institute of Biomaterials at the Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Germany. Prior to this appointment, he was Professor of Materials Science and Engineering at Imperial College London, UK (2000-2009). He has remained Visiting Professor of Materials at Imperial College London. He is also visiting professor at Nagoya Institute of Technology (Japan), RWTH Aachen University (Germany) and Universidad Nacional de Cuyo (Argentina). The research activities of Prof. Boccaccini are in the broad area of glasses, ceramics and polymer/glass composites for biomedical, functional and/or structural applications. Prof. Boccaccini has also developed the electrophoretic deposition technique for production of nanostructured materials and composites with defined surface topography with potential use in the biomedical field. He is the author or co-author of more than 450 scientific papers and 15 book chapters. Boccaccini is Fellow of the Institute of Materials, Minerals and Mining (UK) and of the American Ceramic Society. He is the Editor-in-Chief of the journal “Materials Letters” (Elsevier) and serves in the editorial board of several recognized international journals. He has also edited two books with Elsevier.

Affiliations and expertise

Professor of Biomaterials, Head of the Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Germany

P.X. Ma

Ma is the Richard H Kingery Endowed Collegiate Professor of Biologic and Materials Sciences, Biomedical Engineering, Materials Science and Engineering, and Macromolecular Science and Engineering at the University of Michigan. His research is in the areas of biomaterials, biomedical polymers, controlled release, tissue engineering, and regenerative medicine. Among various recognitions, Dr. Ma was named one of the Top 100 materials scientists in the world by Thomson Reuters. He is an elected Fellow of the American Institute for Medical and Biological Engineering, Fellow of Biomaterials Science and Engineering, Fellow of the Materials Research Society and Fellow of American Association for the Advancement of Science.

Affiliations and expertise

Richard H Kingery Endowed Collegiate Professor, University of Michigan, USA

Liliana Liverani

Liliana Liverani is a Senior Researcher at the Institute of Biomaterials, University of Erlangen-Nuremberg. She has expertise on the synthesis and functionalization of polymers and composites for tissue engineering applications, mainly by using the electrospinning technique.

Affiliations and expertise

Senior Research Associate, Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Germany