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The Vasculome
From Many, One
- 1st Edition - June 11, 2022
- Editor: Zorina S. Galis
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 5 4 6 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 5 4 7 - 9
The Vasculome: From Many, One introduces the fundamental bases of the “unity in diversity” of the Vasculome, from the coming together of various cell lineages during developme… Read more
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Request a sales quoteThe Vasculome: From Many, One introduces the fundamental bases of the “unity in diversity” of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney.
Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section.
Zorina Galis' The Vasculome was named a finalist in the Clinical Medicine category of the American Association of Publishers’ 2023 PROSE Awards.
- 2023 PROSE Awards - Winner: Finalist: Clinical Medicine: Association of American Publishers
- Brings together leading experts who present the latest biomedical thinking about the vasculature from the integrative perspective of the Vasculome
- Challenges traditional real and perceived boundaries within vascular research areas and stimulates new fundamental thinking and medical explorations
- Creates the bases for translating the integrative Vasculome concept into improved fundamental and clinical assessment and management of local and systemic contributions of the vasculature in health and disease
- Cover image
- Title page
- Table of Contents
- Companion website
- Copyright
- Contributors
- Preamble
- Acknowledgment
- List of abbreviations
- The architectural design of the vasculome: basis for system-wide functional unity and local diversity
- Section 1. The endothelium: key unifying principle of the vasculome. Basis for systemic unity and for engineering of local specialization
- Chapter 1. Development of, and environmental impact on, endothelial cell diversity
- Introduction
- Diversity of endothelial cell types
- Endothelial cell diversity within adult organs
- Impact of environmental factors on endothelial cell specification
- Epigenetic and noncoding RNA regulation of endothelial cell phenotype
- Summary and conclusions
- Chapter 2. Endothelial cell heterogeneity and plasticity in health and disease—new insights from single-cell studies
- Introduction
- Endothelial cell heterogeneity and plasticity
- Angiogenic EC phenotypes
- EC metabolic heterogeneity
- EC heterogeneity in tissue repair
- EC heterogeneity in cancer
- Perspectives and therapeutic implications
- Section 2. Vasculome’s key building blocks—beyond the endothelium
- Chapter 3. The remarkable diversity of vascular smooth muscle in development and disease: a paradigm for mesenchymal cell types
- Introduction
- The vascular system is a developmental mosaic
- Assembly of the vessel wall in development
- Self-organization guides artery wall development
- Positional identity and VSMC diversity
- VSMC differentiation, phenotypic switching, and reprogramming
- VSMC reprogramming to multiple mesenchymal cell types
- Role of Krüppel-like factor 4 in VSMC reprogramming
- VSMC single-cell transcriptomes and VSMC reprogramming
- VSMC single-cell transcriptomes and embryonic origins
- Vascular smooth muscle clonal expansions in vivo
- SMC diversity: one genome, many epigenomes
- VSMCs—a paradigm for mesenchymal cell types
- Does VSMC reprogramming extend “the vasculome” beyond the vascular system?
- Chapter 4. Smooth muscle diversity in the vascular system
- Introduction
- Vascular smooth muscle cell diversity: contractile properties
- Vascular smooth muscle cell diversity in vasomotor control and signaling networks
- Alternative splicing to rewire signaling networks
- Newer methodologies for the study of smooth muscle diversity
- Conclusion
- Chapter 5. Resident vascular immune cells in health and atherosclerotic disease
- Macrophages
- Granulocytes
- Dendritic cells
- CD4+ and CD8+ T cells
- Other T cell subsets
- B cells
- Other lymphoid cells
- Conclusion
- Chapter 6. Perivascular adipose tissue: friend or foe?
- Introduction
- PVAT vascular functions
- Perivascular adipose tissue implications in pathology
- Conclusion
- Chapter 7. Major vascular ECM components, differential distribution supporting structure, and functions of the vasculome
- Structure and function of the vasculome
- Major vascular ECM proteins
- The ECM and its interactions with cells
- Conclusions
- Section 3. Putting it all together: vasculome integration across body scales and within tissues
- Chapter 8. Out to the tissues: the arterial side (arteries, arterioles—development, structure, functions, and pathologies)
- Introduction
- The arterial wall: development, structure, and function
- Arterial pathologies
- Conclusion
- Chapter 9. Capillary diversity: endothelial cell specializations to meet tissue metabolic needs
- Introduction
- Attributes of capillary endothelial cells
- Maintenance and expansion of capillary networks
- Endothelial control of nutrient delivery
- Release of angiocrine factors to support tissue physiology
- Endothelial cell role in immune surveillance
- Indicators of tissue-specific endothelial cell plasticity?
- Consequences of compromised endothelial cell performance
- Conclusions
- Chapter 10. The neurovascular unit and blood–CNS barriers in health and disease
- The neurovascular unit and the blood–CNS barrier in the healthy state
- CNS angiogenesis and BBB/BRB development
- Vascular basement membrane and CNS vascular barrier maturation
- The neurovascular unit and blood–CNS barriers in neurological and ocular diseases
- Chapter 11. Lymphatic biology and medicine
- Introduction
- Lymphatic vasculature
- Lymphangiogenesis
- Lymphedema
- Pathological conditions with lymphatic defects
- Concluding remarks
- Investigating the vasculome: context-driven methods, uses, and limitations
- Section 1. Experimental and computational studies of the vasculome
- Chapter 12. The flow-dependent endotheliome: hemodynamic forces, genetic programs, and functional phenotypes
- Introduction
- Flow patterns in the human circulation
- Modeling human hemodynamic forces in vitro
- Unraveling flow-dependent endothelial gene expression and functional phenotypes
- Conclusions and future directions
- Chapter 13. Intravital photoacoustic microscopy of microvascular function and oxygen metabolism
- Introduction
- Multiparametric PAM: the working principles
- Intravital PAM of the skin microvasculature
- Intravital PAM of the dorsal vasculature
- Intravital PAM of the cerebral microvasculature
- Intravital PAM of the microvasculature in other tissues and organs
- Frontiers in intravital PAM of the microvasculature
- Conclusion
- Chapter 14. Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases
- Introduction
- Computational models of HIF stabilization and HIF-mediated cellular pathways in angiogenesis
- Computational models of growth factor-mediated signaling pathways regulating angiogenesis
- Computational multipathway models of endothelial cells and macrophages in angiogenesis
- Discussion and future perspectives
- Chapter 15. Simulation of blood flow and oxygen transport in vascular networks
- Introduction
- Simulation of blood flow
- Simulation of oxygen transport
- Discussion
- Chapter 16. Clinical investigations of vascular function
- Vascular endothelial function
- Arterial stiffness
- Conclusions
- Appendix A. Supplementary data
- Section 2. Realizing the promise of new high-content technologies
- Chapter 17. Angiodiversity—A tale retold by comparative transcriptomics
- Introduction
- Chapter 18. Using pattern recognition and discriminant analysis of functional perfusion data to create “angioprints” for normal and perturbed angiogenic microvascular networks
- Introduction
- Overall experimental design
- Results
- Discussion
- Methods
- Experimental data
- Automated pattern recognition and discrete optimization-based classification model for discriminant analysis
- Image-based pattern recognition algorithm
- Chapter 19. Artificial intelligence for the vasculome
- Introduction
- Conclusion
- Vasculome dynamics: in health and in sickness
- Section 1. Cooperating during development and organogenesis to create vasculome diversity
- Chapter 20. Vascular development and organogenesis: depots of diversity among conduits of connectivity define the vasculome
- Introduction
- Historical perspective of the vasculome concept
- Vascular development and organogenesis: where it all starts
- Vascular development and organogenesis: location-dependent crosstalk
- Circulation-dependent input for local vascular specialization
- The vasculome: conclusions and future directions
- Chapter 21. Normal vascular identity (arteries, veins, and lymphatics) and malformations
- Introduction
- Vasculogenesis: arteriovenous differentiation
- Angiogenesis: sprouting angiogenesis
- Establishing vascular identity
- Vascular malformations
- Vascular tumors
- Switching of arterial–venous identity
- Summary
- Chapter 22. Sprouting angiogenesis in vascular and lymphatic development
- Vascular development
- Sprouting angiogenesis
- Vascular endothelial growth factor and regulation of tip cell formation
- Guidance receptor signaling
- The Notch directive: tip or stalk?
- Refinement of sprouting angiogenesis by BMP signals
- Lymphatic development
- Section 2. Physiological and pathological remodeling of the vasculome
- Chapter 23. Enablers and drivers of vascular remodeling
- Introduction
- Brief on vascular mechanics
- Biological and physiological consequences of mechanics
- Mechanobiology and SMC phenotype
- ECM turnover in evolving mechanical states
- Mechanical homeostasis—an organizing principle
- Conclusion
- Appendix 1
- Chapter 24. Extracellular matrix dynamics and contribution to vascular pathologies
- Atherosclerosis
- Vascular calcification
- Arterial stiffening
- Aneurysms
- Limitations and areas needing further study
- Chapter 25. Lymphatic vascular anomalies and dysfunction
- Introduction
- Lymphatic vascular tumors
- Lymphatic malformations
- Lymphatic malformations associated with other vascular malformations or overgrowth syndromes
- Primary lymphedema
- Conclusions
- Part IV. The vasculome as perpetrator and victim in local and systemic diseases
- Chapter 26. Endothelial dysfunction: basis for many local and systemic conditions
- Introduction
- Physiological role of endothelial (vascular) function
- Mechanisms of endothelial dysfunction
- Therapeutic prevention of endothelial (vascular) dysfunction
- Conclusions and clinical implications
- Chapter 27. The vascular phenotype in hypertension
- Introduction
- Vascular function: integration of vascular smooth muscle contraction/relaxation
- Vascular remodeling in hypertension
- The immune system and inflammation—a new paradigm in the vascular phenotype in hypertension
- Perivascular adipose tissue influences vascular function in hypertension
- Vascular aging in hypertension
- Conclusions
- Chapter 28. Functional roles of lymphatics in health and disease
- Introduction
- Lymphatics in adipose metabolism and obesity
- Lymphatics in skin regeneration
- Lymphatics in the central nervous system
- Alzheimer's disease
- Aging
- Lymphatic function in aqueous drainage and glaucoma
- Lymphatics in cardiovascular disease
- Atherosclerosis
- Myocardial infarction
- Conclusions
- Chapter 29. Extracellular matrix genetics of thoracic and abdominal aortic diseases
- Thoracic aortic aneurysms predispose to acute aortic dissections
- Heritable thoracic aortic disease genetics highlights the importance of maintaining an aortic structural component, the elastin-contractile unit
- The genetics of abdominal aortic aneurysms
- The extracellular matrix in genetics of aortic disease
- Chapter 30. Peripheral arterial disease (pathophysiology, presentation, prevention/management)
- Introduction
- PAD: epidemiology and risk factors
- Diagnosis and initial evaluation
- Spectrum of disease
- Pathophysiology and pathobiology
- Disease management
- PAD therapies in development
- Conclusions
- Chapter 31. Venous diseases including thromboembolic phenomena
- Venous thrombogenesis with special emphasis on selectins
- Venous thrombosis and resolution
- Pre-clinical/basic science models
- Preclinical/translational models
- Research reproducibility/comparative pathology/statistical consultation
- New areas of venous research in thrombogenesis, resolution, and novel approaches for the future
- Part V. The vasculome in diagnosis, prevention, and treatment of other diseases
- Chapter 32. Targeting vascular zip codes: from combinatorial selection to drug prototypes
- Introduction
- A brief history of phage display
- In vivo phage display and vascular zip codes
- Human vascular mapping project
- Translational/clinical applications
- Bone Metastasis Targeting Peptidomimetic-11 (BMTP-11)
- Adipotide
- Other zip codes
- Conclusions
- Chapter 33. Angiosome concept for vascular interventions
- Introduction
- Clinical implementation of the angiosome model in the current treatment of CLTI
- Summary
- Chapter 34. RNA therapies for cardiovascular disease
- Introduction to RNA therapeutics
- RNA therapeutics in lipid disorders
- Emerging RNA therapeutics for cardiac transthyretin amyloidosis
- Future perspectives
- Chapter 35. The brain vasculome: an integrative model for CNS function and disease
- Introduction
- Vasculome modifying factors
- Cell–Cell interactions
- Levels of vasculome mapping
- The functional vasculome
- Conclusions and future directions
- Part VI. Looking forward toward “Precision Health” for the vasculome
- Chapter 36. Vasculome: defining and optimizing vascular health
- Introduction
- Conclusion
- Chapter 37. The Vasculome provides a body-wide cellular positioning system and functional barometer. The “Vasculature as Common Coordinate Frame (VCCF)” concept
- Key requirements for a common coordinate frame (CCF) for the human body
- Evaluating the vasculature as CCF and road map for the human body
- Practical considerations for using the vasculature as a human body CCF
- Vasculature as a barometer of functional tissue status and health
- Parting thoughts
- Index
- No. of pages: 526
- Language: English
- Edition: 1
- Published: June 11, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780128225462
- eBook ISBN: 9780128225479
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