The Vascular Endothelium
A Holistic Approach for Oncology
- 1st Edition - June 6, 2022
- Imprint: Academic Press
- Authors: Domenico Ribatti, Francesco Pezzella
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 4 3 7 1 - 8
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 4 3 9 2 - 3
The Vascular Endothelium: A Holistic Approach for Oncology provides novel and integrated knowledge on the endothelial cells as a crucial component involved in the growth of differ… Read more
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The Vascular Endothelium: A Holistic Approach for Oncology provides novel and integrated knowledge on the endothelial cells as a crucial component involved in the growth of different organs in both physiological and pathological conditions. By covering diverse aspects of anatomy, embryology, molecular biology and pathology, it details the important role of the endothelium for the pathogenesis of cancer and how this knowledge can improve the outcome of cancer research.
The content is split in six parts: appearance and evolution of the endothelial cell, which discusses for instance comparative anatomy of the endothelium in relation to the vascular system; endothelial cell in embryology and organogenesis, covering the interaction between endothelial and hematopoietic cells; the lymphatic system, which brings information on lymphatic endothelial cell markers and molecular regulation of lymphangiogenesis; the anatomy of the endothelium in adults, showing the differences in the mature endothelial cells through the body; the physiology of the endothelial cells, with organ specific physiological activity of the endothelium; and the endothelial cells in cancer, discussing the use of endothelium as target for treatment and current therapeutic approaches.
This book is a valuable resource for cancer researchers, oncologists and other members of biomedical field who are interested to learn more about the complexity of vascular endothelium and its impact on cancer and other related diseases.
The content is split in six parts: appearance and evolution of the endothelial cell, which discusses for instance comparative anatomy of the endothelium in relation to the vascular system; endothelial cell in embryology and organogenesis, covering the interaction between endothelial and hematopoietic cells; the lymphatic system, which brings information on lymphatic endothelial cell markers and molecular regulation of lymphangiogenesis; the anatomy of the endothelium in adults, showing the differences in the mature endothelial cells through the body; the physiology of the endothelial cells, with organ specific physiological activity of the endothelium; and the endothelial cells in cancer, discussing the use of endothelium as target for treatment and current therapeutic approaches.
This book is a valuable resource for cancer researchers, oncologists and other members of biomedical field who are interested to learn more about the complexity of vascular endothelium and its impact on cancer and other related diseases.
- Provides a holistic approach to the knowledge of endothelial cells in different organs, from early years of development to adulthood
- Discusses relevant aspects of endothelial cells related to the pathogenesis of cancer to be applied to novel therapeutics
- Presents an interdisciplinary view of the vascular endothelium, covering anatomy, embryology, molecular biology, pathology and clinical implications
Cancer researchers, oncologists, graduate students, medical scientists
1. Appearance and evolution of the endothelial cell1.1. Appearance of a circulatory system1.2. Evolution of the endothelium1.3. Comparative anatomy of the endothelium in relationship to the vascular system2. Endothelial cell in embryology and organogenesis2.1. Vasculogenesis and angiogenesis2.2. Outline of vasculogenesis2.3. Outline of angiogenesis2.4. The relationship between endothelial and hematopoietic cells2.5. Paracrine activity of endothelial cells3. The lymphatic system3.1. Development of the lymphatic system3.2. Lymphatic endothelial cell markers3.3. Molecular regulation of lymphangiogenesis4. The microscopic and molecular anatomy of the endothelium in adult4.1. Microscopic anatomy of the vessels and their endothelium4.2. The biology of the mature endothelial cells through the body5. The physiology of the endothelial cells5.1. Basic physiology of the endothelial cells5.2. Organ specific physiological activity of the endothelium6. The endothelial cells in cancer: An outline6.1. Different types of vessels and endothelial cells in cancer6.2. Endothelium as target for treatment6.3. Current therapeutic approaches
- Edition: 1
- Published: June 6, 2022
- Imprint: Academic Press
- Language: English
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Domenico Ribatti
Domenico Ribatti was awarded his M.D. degree in October 1981, with full marks. In 1983, D.R. joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology (Prof. R. Montesano). In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara (Romania). D.R. is author of 866 publications as reported in PUBmed and contributed to 50 chapters to books. Overall, his papers have been cited 51153 times.
He has published many books with both Elsevier and Springe
Affiliations and expertise
Full Professor of Human Anatomy, University of Bari Medical School, Bari, ItalyFP
Francesco Pezzella
Francesco Pezzella is a histopathologist and is currently Professor of Tumour Pathology at Oxford. He worked in the past on the pathology of HIV (at the time HTLV III) infection and molecular alterations in lymphoma. Because of his friends pushing him into the field of cancer and blood vessels, eventually he discovered in the mid-nineties, by pure chance, the tumours growing without angiogenesis.
Affiliations and expertise
Professor of Tumour Pathology, Nuffield Division of Clinical Laboratory Science-Radcliffe Department of Medicine, University of Oxford, UKRead The Vascular Endothelium on ScienceDirect