The Vascular Endothelium
A Holistic Approach for Oncology
- 1st Edition - May 29, 2022
- Imprint: Academic Press
- Authors: Domenico Ribatti, Francesco Pezzella
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 4 3 7 1 - 8
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 4 3 9 2 - 3
The Vascular Endothelium: A Holistic Approach for Oncology provides novel and integrated knowledge on the endothelial cells as a crucial component involved in the growth of differ… Read more
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Request a sales quoteThe Vascular Endothelium: A Holistic Approach for Oncology provides novel and integrated knowledge on the endothelial cells as a crucial component involved in the growth of different organs in both physiological and pathological conditions. By covering diverse aspects of anatomy, embryology, molecular biology and pathology, it details the important role of the endothelium for the pathogenesis of cancer and how this knowledge can improve the outcome of cancer research.
The content is split in six parts: appearance and evolution of the endothelial cell, which discusses for instance comparative anatomy of the endothelium in relation to the vascular system; endothelial cell in embryology and organogenesis, covering the interaction between endothelial and hematopoietic cells; the lymphatic system, which brings information on lymphatic endothelial cell markers and molecular regulation of lymphangiogenesis; the anatomy of the endothelium in adults, showing the differences in the mature endothelial cells through the body; the physiology of the endothelial cells, with organ specific physiological activity of the endothelium; and the endothelial cells in cancer, discussing the use of endothelium as target for treatment and current therapeutic approaches.
This book is a valuable resource for cancer researchers, oncologists and other members of biomedical field who are interested to learn more about the complexity of vascular endothelium and its impact on cancer and other related diseases.
The content is split in six parts: appearance and evolution of the endothelial cell, which discusses for instance comparative anatomy of the endothelium in relation to the vascular system; endothelial cell in embryology and organogenesis, covering the interaction between endothelial and hematopoietic cells; the lymphatic system, which brings information on lymphatic endothelial cell markers and molecular regulation of lymphangiogenesis; the anatomy of the endothelium in adults, showing the differences in the mature endothelial cells through the body; the physiology of the endothelial cells, with organ specific physiological activity of the endothelium; and the endothelial cells in cancer, discussing the use of endothelium as target for treatment and current therapeutic approaches.
This book is a valuable resource for cancer researchers, oncologists and other members of biomedical field who are interested to learn more about the complexity of vascular endothelium and its impact on cancer and other related diseases.
- Provides a holistic approach to the knowledge of endothelial cells in different organs, from early years of development to adulthood
- Discusses relevant aspects of endothelial cells related to the pathogenesis of cancer to be applied to novel therapeutics
- Presents an interdisciplinary view of the vascular endothelium, covering anatomy, embryology, molecular biology, pathology and clinical implications
Cancer researchers, oncologists, graduate students, medical scientists
- Cover image
- Title page
- Table of Contents
- Copyright
- 1. Appearance and evolution of the endothelial cell
- 1.1. Appearance of a circulatory system
- 1.2. Coeloma, the basic circulatory system
- 1.3. The hemel, vascular channel without endothelium
- 1.4. The oldest endothelium
- 1.5. Why there are advantages in an endothelium-lined vessel?
- 1.6. How endothelium evolved?
- 1.7. Conclusions
- 2. Endothelial cell in embryology and organogenesis
- 2.1. Vasculogenesis and angiogenesis
- 2.2. Prenatal vasculogenesis
- 2.3. Postnatal vasculogenesis
- 2.4. Angiogenesis
- 2.5. The relationship between endothelial and hematopoietic cells
- 3. The lymphatic system
- 3.1. Lymphangiogenesis
- 3.2. Structural features of the lymphatic system and lymphatic endothelial cell markers
- 3.3. Molecular regulation of lymphangiogenesis
- 4. The physiology of the endothelial cells
- 4.1. Introduction
- 4.2. Different types of vessels
- 4.3. The main physiological functions of the endothelial cells
- 4.4. The interaction between endothelial cells
- 4.5. Adhesion with the basement membrane
- 4.6. Angiocrine activity of endothelial cells
- 4.7. Endothelium as a barrier: exchange of oxygen, nutrients plus other metabolites, and catabolites
- 4.8. Respiration: molecules diffusion through the endothelium
- 4.9. Glucose transport: diffusion carrier and bulk flow
- 4.10. Control of the vascular tone
- 4.11. The metabolism of the endothelial cells
- 4.12. The nonproliferating endothelium: maintaining the homeostasis
- 4.13. The proliferating endothelium
- 4.14. Immune response: recruitment and transit regulation of immune cells
- 4.15. Triggers for endothelial leukocytes active interaction
- 4.16. The interaction between endothelium and immune cells in inflammation
- 4.17. The high endothelium venules in lymphatic organs
- 4.18. Hemostasis and the endothelium
- 5. The ultrastructure of the endothelial cells
- 6. The endothelial cells in cancer: an outline
- 6.1. Endothelial cells in intratumor vessels
- 6.2. Specific studies on endothelium from co-opted normal preexisting vessels
- 6.3. High throughput studies
- 6.4. Metabolism of intratumor endothelium
- 6.5. Immunity and intratumor endothelium
- 6.6. Vasculogenic mimicry
- 6.7. Endothelial cells with aneuploidy
- 6.8. Endothelial cells harboring the tumor chromosomal abnormalities
- 6.9. Endothelial cells with chromosomal instability
- 6.10. Circulating endothelial cells in cancer patients
- 6.11. Endothelium as target for treatment
- Index
- Edition: 1
- Published: May 29, 2022
- No. of pages (Paperback): 146
- No. of pages (eBook): 146
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128243718
- eBook ISBN: 9780128243923
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Domenico Ribatti
Domenico Ribatti was awarded his M.D. degree in October 1981, with full marks. In 1983, D.R. joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology (Prof. R. Montesano). In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara (Romania). D.R. is author of 866 publications as reported in PUBmed and contributed to 50 chapters to books. Overall, his papers have been cited 51153 times.
He has published many books with both Elsevier and Springe
Affiliations and expertise
Full Professor of Human Anatomy, University of Bari Medical School, Bari, ItalyFP
Francesco Pezzella
Francesco Pezzella is a histopathologist and is currently Professor of Tumour Pathology at Oxford. He worked in the past on the pathology of HIV (at the time HTLV III) infection and molecular alterations in lymphoma. Because of his friends pushing him into the field of cancer and blood vessels, eventually he discovered in the mid-nineties, by pure chance, the tumours growing without angiogenesis.
Affiliations and expertise
Professor of Tumour Pathology, Nuffield Division of Clinical Laboratory Science-Radcliffe Department of Medicine, University of Oxford, UKRead The Vascular Endothelium on ScienceDirect