The Scientific Basis of Mpox (Monkeypox)
Features, Prevention, and Treatments
- 1st Edition - November 1, 2024
- Editors: Rajkumar Rajendram, Vinood Patel, Victor R Preedy
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 2 1 2 3 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 2 1 2 2 - 4
The Scientific Basis of Monkeypox: Features, Prevention, and Treatments advances understanding of monkeypox, and provides a framework for future research with evidence-based and fo… Read more
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Request a sales quoteThe Scientific Basis of Monkeypox: Features, Prevention, and Treatments advances understanding of monkeypox, and provides a framework for future research with evidence-based and forward-looking content. Content makes use of modelling systems and current experiences derived from case studies to provide material that is cross-disciplinary, bridging interdisciplinary divides. Furthermore, consideration is given to the behavioral response to monkeypox infection including the barriers to vaccination. Content is split into 9 sections with each individual chapter containing structured content including policy and procedures, applications to new or emerging communicable diseases, a mini dictionary of terms, and summary points. Chapter contributions are from leading national and international specialists including those from world renowned institutions to provide a global perspective. The book is a perfect reference for specialists in infectious diseases, virologists, microbiologists, health scientists, public health workers, doctors, pharmacologists and research scientists.
- Summarizes monkeypox using evidenced based ethos
- Provides practical details, recommendations and suggestions for research, prevention, and treatment: from cells to policy
- Provides forward thinking application to new and emerging communicable diseases
Virologists and epidemiologistsPrimary care physicians, health practioners
Section 1 Setting the Scene and Introductory
1. Monkeypox: The clinical and epidemiological context
2. Classification of viruses: the position of monkeypox
3. Monkeypox in different parts of the world
Section 2 The Biology of Monkeypox
4. The biological features of monkeypox: an overview
5. Monkeypox transmission
6. Sequencing the monkeypox virus
7. Coinfections of monkeypox with other communicable infectious
Section 3 Detection and Confirmation
8. Clinical signs and symptom of monkeypox infection
9. PCR diagnosis and analysis of monkeypox virus
Section 4 Behaviour and Neurology
10. Behaviour aspects of infected individuals: intention to vaccinate and isolation
11. Barriers in mass vaccination: implications for monkeypox
12. Neurologic aspects of viral diseases: a focus on monkeypox
Section 5 Effects on Tissues and Organs Systems
13. Skin changes and histopathology of monkeypox
14. Proctitis in monkeypox infection
Section 6 Vaccinations, Treatments and Alleviation of Symptomology
15. Vaccines against monkeypox
16. Immune prophylaxis for monkeypox infection
17. Tecovirimat, the VP37 envelope wrapping protein and potential for monkeypox
18. Brincidofovir for treating monkeypox
19. Adamantane derivatives as potential inhibitors of p37 envelope protein rof
20. Supportive care in monkeypox infectiion: mouthwashes, analgesics and antihistamines
Section 7 Modelling
21. Compartmental model of monkeypox dynamics and applications to vaccination
22. Non-human primate modelling of monkeypox
23. The wild-derived inbred CAST mouse to study monkeypox virus
Section 8 Case Studies
24. Case Study: Monkeypox in an individual
25. Case Study: Monkeypox and intestinal involvements: proctitis
Section 9 Resources
Resources for the study and investigation of monkeypox
1. Monkeypox: The clinical and epidemiological context
2. Classification of viruses: the position of monkeypox
3. Monkeypox in different parts of the world
Section 2 The Biology of Monkeypox
4. The biological features of monkeypox: an overview
5. Monkeypox transmission
6. Sequencing the monkeypox virus
7. Coinfections of monkeypox with other communicable infectious
Section 3 Detection and Confirmation
8. Clinical signs and symptom of monkeypox infection
9. PCR diagnosis and analysis of monkeypox virus
Section 4 Behaviour and Neurology
10. Behaviour aspects of infected individuals: intention to vaccinate and isolation
11. Barriers in mass vaccination: implications for monkeypox
12. Neurologic aspects of viral diseases: a focus on monkeypox
Section 5 Effects on Tissues and Organs Systems
13. Skin changes and histopathology of monkeypox
14. Proctitis in monkeypox infection
Section 6 Vaccinations, Treatments and Alleviation of Symptomology
15. Vaccines against monkeypox
16. Immune prophylaxis for monkeypox infection
17. Tecovirimat, the VP37 envelope wrapping protein and potential for monkeypox
18. Brincidofovir for treating monkeypox
19. Adamantane derivatives as potential inhibitors of p37 envelope protein rof
20. Supportive care in monkeypox infectiion: mouthwashes, analgesics and antihistamines
Section 7 Modelling
21. Compartmental model of monkeypox dynamics and applications to vaccination
22. Non-human primate modelling of monkeypox
23. The wild-derived inbred CAST mouse to study monkeypox virus
Section 8 Case Studies
24. Case Study: Monkeypox in an individual
25. Case Study: Monkeypox and intestinal involvements: proctitis
Section 9 Resources
Resources for the study and investigation of monkeypox
- No. of pages: 500
- Language: English
- Edition: 1
- Published: November 1, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780443221231
RR
Rajkumar Rajendram
Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.
Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.
Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.
Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.
Affiliations and expertise
Consultant in Internal Medicine, King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi ArabiaVP
Vinood Patel
Vinood B. Patel, BSc, PhD, FRSC, is currently Professor in Clinical Biochemistry at the University of Westminster. In 2014 Dr Patel was elected as a Fellow to The Royal Society of Chemistry. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School, NC, USA studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding mitochondrial oxidative stress in neurological disorders and iron dysregulation in diabetes. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to the use or investigation of active agents or components. These books include The Handbook of Nutrition, Diet, and Epigenetics, Branched Chain Amino Acids in Clinical Nutrition, Cancer: Oxidative Stress and Dietary Antioxidants, Toxicology: Oxidative Stress and Dietary Antioxidants, Molecular Nutrition: Vitamins, The Neuroscience of Pain, Cognitive Behavioural Therapy. He is Editor of the ten-volume series Biomarkers in Disease: Methods, Discoveries and Applications.
Affiliations and expertise
Reader, Clinical Biochemistry, University of Westminster, London, UKVP
Victor R Preedy
Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.
Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK Visiting Professor, University of Hull, UK