The Scientific Basis of Mpox (Monkeypox)

Features, Prevention, and Treatments

1st Edition - September 30, 2024
Editors: Rajkumar Rajendram, Vinood Patel, Victor R Preedy
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 2 2 1 2 3 - 1
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 2 2 1 2 2 - 4

The Scientific Basis of Monkeypox: Features, Prevention, and Treatments advances understanding of monkeypox and provides a framework for future research with evidence-based and fo… Read more

The Scientific Basis of Mpox (Monkeypox)

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The Scientific Basis of Monkeypox: Features, Prevention, and Treatments advances understanding of monkeypox and provides a framework for future research with evidence-based and forward-looking content. Content makes use of modeling systems and current experiences derived from case studies to provide material that is cross-disciplinary, bridging interdisciplinary divides. Furthermore, consideration is given to the behavioral response to monkeypox infection, including barriers to vaccination. Each chapter contains structured content, including policy and procedures, applications to new or emerging communicable diseases, a mini dictionary of terms, and summary points.

Chapter contributions are from leading national and international specialists, including those from world renowned institutions who provide a global perspective. The book is a perfect reference for specialists in infectious diseases, virologists, microbiologists, health scientists, public health workers, doctors, pharmacologists, and research scientists.

Preface

Section 1: Setting the Scene and Introductory Chapters

1. A synopsis of mpox
Heidi M. Torres

2. Monkeypox unveiled: understanding its impact on public health
Professor Dr. Roy Rillera Rillera Marzo

3. Human mpox (monkeypox) virus and its evolution
Jonas Wolf Sr., Lucas Wolf, Ana Paula de Souza, Arthur Pille, Jucara Gasparetto Maccari and Luiz Antonio Nasi

4. Importance of emerging lineages of mpox (monkeypox) virus: an updated narrative
Mayla Abrahim and Alexandro Guterres

5. Bridging borders: the collective fight against monkeypox outbreaks
Professor Dr. Roy Rillera Rillera Marzo

6. Social media and the response to mpox (monkeypox)
David C. Coker

Section 2: The Biology And Transmission Of mpox (monkeypox)

7. Monkeypox virus: fundamental features of its particle, replication cycle, cytopathic effects and research models
Amanda Stéphanie Arantes Witt, Ana Gabriella Stoffella-Dutra, Nidia Esther Colquehuanca Arias, Thalita Souza Arantes, Denilson Eduardo Silva Cunha, Jonatas Abrahao and Giliane de Souza Trindade

8. Biology of the mpox virus and the cysteine protease structures and basis of in silico studies
Hardeep Singh Tuli and Tejveer Singh

9. The serial interval distributions of the mpox virus infection
Shi Zhao, Zihao Guo and Sheikh Taslim Ali

10. Investigating mpox: linking web tools and genomic analysis
José Luis Zambrano Rouvier, Flor H. Pujol, Zoila C. Moros, Carmen L. Loureiro, Rossana C. Jaspe, Yoneira Sulbaran and David S. Coll

11. Mathematical Modelling of Mpox: A Review
Jan Rychtar, Dewey Taylor and Oyita Udiani

Section 3: Detection And Confirmation

12. Development, validation, and use of assays within the clinical diagnostic and Emergency Use Authorization/Food and Drug Administration (EUA/FDA) contexts
Kurt Schaecher

13. Primers and Probes for the Diagnostics of mpox (monkeypox) Virus
Fuqing Wu

14. Monkeypox and wastewater surveillance: tracing the spread of a viral outbreak through environmental monitoring
Giuseppina La Rosa, Elisabetta Suffredini and Marcello Iaconelli

Section 4: Effects On the Body. Tissues And Organs Systems

15. Time related change in skin lesions and their progression
Yeimer Ortiz-Martínez and Andrés F. Henao-Martínez

16. Atypical skin manifestations of mpox
Andrés Grau-Echevarría Sr., R. Penuelas Leal, Carolina Labrandero, Daniel Blaya Imbernón Sr., Malena Finello and Pablo Hernandez Sr.

17. Variations in clinical features and symptoms in mpox (monkeypox) infection: fever and beyond
R. Penuelas Leal, Carolina Labrandero, Andrés Grau-Echevarría Sr., Daniel Blaya Imbernón Sr., Malena Finello and Pablo Hernandez Sr.

18. Otolaryngological features of mpox: lymphadenopathy, pharyngeal and airways
Kaitlyn Aragon Brooks, Nathaniel Neptune and Douglas Mattox

19. Cardiac involvement of mpox (monkeypox)
Ana Isabel Pinho and Marta Braga

Section 5: Vaccinations, Treatments And Alleviation Of Symptomology

20. The psychological responses of mpox (monkeypox) virus vaccination in health care workers: international aspects
Ramy Mohamed Ghazy I, Engy El-Ghitany, Hoda Ali Ahmed Shiba, Safar Abadi Alsaleem Alshahrani, Ehab Elrewany and Dalia El Samhouri

21. Immunoinformatics and mpox (monkeypox) virus vaccines
Budheswar Dehury and Sarbani Mishra

22. Barriers to mass vaccination against monkeypox: an overview
SEMEEH AKINWALE OMOLEKE and Enya Bassey

23. Approved and experimental antivirals for mpox
Bichitra Kumar. Biswal, Swati Kumari and Sonanjali Aneja

24. Repurposing drugs for monkeypox using artificial intelligence
Chiragkumar Patel and Raghvendra Mall

25. Monkey Pox clinical management-A Review
ANIL Kumar SHARMA

26. Treating pustular skin lesions in viral infection: mpox and beyond
Pablo Hernandez Sr., Daniel Blaya Imbernón Sr., Malena Finello, R. Penuelas Leal, Carolina Labrandero
and Andrés Grau-Echevarría Sr.

27. Treating concomitant HIV and mpox virus infection
N.N. Pettit, Aniruddha Hazra, Alison Lew, Renslow Sherer, Sabrina Imam and Elizabeth Bell

Section 6: Case Studies

28. Case Study: Mpox (monkeypox) and a typical scenario of clinical presentation, diagnosis and successful treatment
Almira Opardija

29. Case Study: Heterosexual transmission of mpox
Jesus Sánchez Díaz, Laura Montero Morales, Marcos Alonso García, Araceli Arce Arnáez and Jesus Iñigo Martinez

30. Case Report: Simultaneous presentation of human monkeypox virus and sexually transmited diseases (STDs): a diagnostic and management challenge
Maria J. Vivancos-Gallego

31. Case study: Anatomopathological findings in different mpox cutaneous lesions
Carolina Labrandero, Andrés Grau-Echevarría Sr., R. Penuelas Leal, Daniel Blaya Imbernón Sr., Laura Parra Navarro, Pablo Hernandez Sr. and Victor Alegre de Miquel

32. Case Study: Scaring and quality of life in mpox
Pablo Hernandez Sr.

Section 7: Resources

33. Resources for the study and investigation of mpox (monkeypox)
Rajkumar Rajendram

Rajkumar Rajendram

Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.

Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.

Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.

Affiliations and expertise

Consultant in Internal Medicine, King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia

Vinood Patel

Vinood B. Patel, BSc, PhD, FRSC, is currently Professor in Clinical Biochemistry at the University of Westminster. In 2014 Dr Patel was elected as a Fellow to The Royal Society of Chemistry. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School, NC, USA studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding mitochondrial oxidative stress in neurological disorders and iron dysregulation in diabetes. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to the use or investigation of active agents or components. These books include The Handbook of Nutrition, Diet, and Epigenetics, Branched Chain Amino Acids in Clinical Nutrition, Cancer: Oxidative Stress and Dietary Antioxidants, Toxicology: Oxidative Stress and Dietary Antioxidants, Molecular Nutrition: Vitamins, The Neuroscience of Pain, Cognitive Behavioural Therapy. He is Editor of the ten-volume series Biomarkers in Disease: Methods, Discoveries and Applications.

Affiliations and expertise

Reader, Clinical Biochemistry, University of Westminster, London, UK

Victor R Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.

Affiliations and expertise

Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK Visiting Professor, University of Hull, UK

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The Scientific Basis of Mpox (Monkeypox)

Features, Prevention, and Treatments

Purchase options

Save 50% on book bundles

Institutional subscription on ScienceDirect

Rajkumar Rajendram

Vinood Patel

Victor R Preedy