The Scientific Basis of Fatigue

1st Edition - October 1, 2025
Imprint: Academic Press
Editors: Colin R. Martin, Victor R. Preedy, Vinood Patel, Rajkumar Rajendram
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 2 4 0 8 0 - 5
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 2 4 0 8 1 - 2

Fatigue is a prevalent problem and adequate treatment is challenging because many conditions, disorders, medications, and lifestyle factors can cause fatigue. The Scientific Ba… Read more

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Fatigue is a prevalent problem and adequate treatment is challenging because many conditions, disorders, medications, and lifestyle factors can cause fatigue. The Scientific Basis of Fatigue combines evidence-based research and clinical treatment protocols to provide a comprehensive reference to fatigue. This book is divided into seven distinct sections, starting with an introduction section defining the distinctions between physical and mental fatigue. The second and third sections detail the various conditions in both physical and mental fatigue including COVID, Parkinson disease, and depression. The next section reviews the current research on molecular and cellular aspects and models of fatigue. The final two sections review options for diagnosis and treatments for fatigue and provides a detailed resource section for further review.

Preface

Section 1: Fatigue In Different Conditions and Scenarios

1. Fatigue in clinical conditions: Inflammatory bowel disease. A new narrative
Roald Omdal and Tore Grimstad

2. Fatigue related to cancer treatments
Okan Vardar and Pınar Serçekuş

3. Fatigue in systemic lupus erythematosus
Rosalie Magro

4. Fatigue in patients with inflammatory rheumatic diseases
M. Massalska

5. Fatigue in diverse groups: taxi drivers and beyond
Ayşe Göktaş

6. Fatigue in clinical conditions: Sjogren's syndrome
Denise Ani Mardale, Andra Rodica Balanescu and Kathrine Skarstein

7. Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): linking in brain fog
Naiara Azcue Gonzalez, Rocio Del Pino, Beatriz Tijero Merino and Juan Carlos Gómez Esteban

8. Fatigue in fibromyalgia: a mental and physical context
Maria Luiza L. de Albuquerque, Marcos de Carvalho Alvarez Sr., Henrique Pereira Neiva, Daniel Almeida Marinho and Diogo Monteiro Sr.

9. Fatigue in chronic obstructive pulmonary disease (COPD)
Canan Bozkurt

10. Vocal fatigue
Srirangam Vijayakumar Narasimhan and Kashyap Sahana

11. Work and fatigue in population cohorts: pilots
Michael John Decker and Elizabeth G. Damato

12. Fatigue and quality of life in Parkinson's disease
Talita D'Aguiar Rosa and Sneha Mantri

13. Fatigue in diabetes
Priyal P. Bhatt

14. Fatigue in stroke: a new narrative
Shamay S.M. Ng and Lily Y.W. Ho

15. Fatigue in COVID-19
S. Sahu, Salma Younas, Rajkumar Rajendram and Victor R. Preedy

Section 2: Mental Fatigue

16. Mental fatigue in the postpartum scenario
Dicle Filiz Yıldırım Gökşen, Elif Uludağ and Damla Aksu

17. Features of mental fatigue in defined populations: subjects with psychiatric disease
Agne Stanyte, Julija Gecaite-Stonciene, Alicja Juškienė and Julius Burkauskas

18. Workplace measures of mental fatigue
Mauricio Adolfo Ramírez-Moreno, María A. Hernández-Mustieles, Milton O. Candela-Leal, Juan C. Tudón-Martínez and J.J. Lozoya-Santos

19. Psychological perspective about mental fatigue: a focus on cognitive and motivational-affective abilities
Cecilia Peñacoba, Lorena Gutiérrez Hermoso, Patricia Catalá Sr. and Carmen Écija

20. Mental fatigue in infertility treatment
Sevgi Ozkan, Dicle Filiz Yıldırım Gökşen and Sinem Göral Türkcü

21. Psychosocial dimensions of mental fatigue
Miriam Archana Simon and Amal Al-Ghailani

22. Fatigue and the reciprocal relationship with motor imagery
Franck Di Rienzo, Benjamin Pageaux, Florian Monjo, Guillaume Y. Millet and A. Guillot

Section 3: Molecular And Cellular Aspects and Models

23. The role of glutathione in skeletal muscle fatigue
Daiki Watanabe

24. Muscular fatigue and molecular mechanisms: Tropomyosin receptor kinase B (TrkB) signaling
J. Tomas, Laia Just-Borras, Erica Hurtado, Aleksandra Polishchuk, Marta Balanyà Segura, M.Mar Sabaté and Maria Angel Lanuza

25. Fatigue in inflammatory bowel disease and the role of micronutrients
Charlotte Lock Rud and Palle Bager

26. The mitochondria in fatigue syndromes
Charmaine van Eeden and Jan willem Cohen Tervaert

27. Fatigue and catalytic autoantibodies
Michael Anthony Jensen, Mohsen Nemat-Gorgani and Ron Davis

28. Short chain fatty acids and fatigue
Canhua Xiao

29. Investigating fatigue in rats on high-fat regimens
Chaya Gopalan, Varun Shenoy, Julia Grace Armbruster and Paris Sophia Kinsley

30. Computational modelling of fatigue
Matthew Lu, Daniel Bennett and Trevor Chong

Section 4: Physiological Aspects

31. Temperature in the working environment and effects on fatigue
Zehra Palejwala

32. Mental imagery of fatigue-related multisensory sensations and fMRI
Barbara Tomasino, Gian Luigi GIgli and Mariarosaria Valente

33. Fatigue of the respiratory muscles
Andrew William Sheel, Dean Elliot Mills and Bruno Archiza

34. Overview of cardiorespiratory system involvement in fatigue
L. C. Wooten

35. Fatigue and physiology of exercise performance as a result of COVID-19
Talha KILIÇ and Aysel Yildiz Ozer

Section 5: Diagnosis and Assessments

36. Diagnosis and treatment of fatigue in Long COVID
Thorsten Rudroff

37. Biomarkers, fatigue and long COVID
T. Auguet

38. Questionnaires for screening fatigue: Parkinson's disease
Asenath Huether and Jau-Shin Lou

Section 6: Treating and Managing Fatigue

39. Treating fatigue with dopaminergic regulators; a focus on s (-)-OSU6162
Angelika Sorteberg

40. Potential of using carnosine in ameliorating fatigue
Dominik Kaczmarek

41. Fatigue associated variables in multiple sclerosis and affective drug treatment
Dimos D. Mitsikostas and Panagiotis Gklinos

42. Modulating mental fatigue: use of Creatine, Caffeine or ketones
Peter WR Lemon and Manuel D. Quinones

43. The Role of Bupropion in Managing Fatigue: Clinical Insights and Usage
Juan E. Correa-Morales, María Fernanda Iriarte-Aristizábal, Lennis Jazmin Bedoya-Muñoz, Santiago Guadarrama, Angie Nathalia Hernández Rico and Nidia Mantilla-Manosalva Sr.

44. The Mediterranean diet and effects on fatigue
Sedat ARSLAN and Ayça AYDIN

45. Managing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a new narrative
Stephanie L. Grach

46. Resistance training: features and use in treating fatigue in cancer survivors
I. L. Ribeiro, Alejandra Lorca and Lily Berríos-Contreras

47. Online treatment regimens in chronic fatigue syndrome
Jaime Navarrete, Juan V. Luciano, Juan P. Sanabria-Mazo and Randy Neblett

48. Omega-3 Polyunsaturated Fatty Acids in Fatigue Management: Clinical Applications and Mechanisms
Quang Le Do, Gede Bagus Subha Jana Giri, Kuan-Pin Su and Jane Pei-Chen Chang

Section 7: Resources

49. Resources for Fatigue
Rajkumar Rajendram

Colin R. Martin

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.

Affiliations and expertise

Visiting Professor of Perinatal Wellbeing, Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

Victor R. Preedy

Professor Preedy has been elected as a Fellow to the following Royal Societies: The Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health and Hygiene, the Royal Society for Public Health, the Royal Society of Chemistry, and the Royal Society of Medicine. He was founding Director of the Genomics Centre at King’s College London and held the post from 2006 to 2020. He is a leading expert on the science of health and has a long-standing interest in disease processes, biomarkers, and tissue pathology. He has lectured nationally and internationally. Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and expertise

Professor, Clinical Biochemistry, King’s College Hospital, London, UK. Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK. Visiting Professor of Health Sciences, University of Suffolk, UK

Vinood Patel

Vinood B. Patel, BSc, PhD, FRSC, is currently Professor in Clinical Biochemistry at the University of Westminster. In 2014 Dr Patel was elected as a Fellow to The Royal Society of Chemistry. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School, NC, USA studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding mitochondrial oxidative stress in neurological disorders and iron dysregulation in diabetes. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to the use or investigation of active agents or components. These books include The Handbook of Nutrition, Diet, and Epigenetics, Branched Chain Amino Acids in Clinical Nutrition, Cancer: Oxidative Stress and Dietary Antioxidants, Toxicology: Oxidative Stress and Dietary Antioxidants, Molecular Nutrition: Vitamins, The Neuroscience of Pain, Cognitive Behavioural Therapy. He is Editor of the ten-volume series Biomarkers in Disease: Methods, Discoveries and Applications.

Affiliations and expertise

Professor, Clinical Biochemistry, School of Life Sciences University of Westminster, London, UK

Rajkumar Rajendram

Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.

Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.

Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.

Affiliations and expertise

Consultant, Medical Protocol Department, King Abdulaziz Medical City, Ministry of National Guard Heath Affairs, Riyadh, Saudi Arabia

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The Scientific Basis of Fatigue

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Colin R. Martin

Victor R. Preedy

Vinood Patel

Rajkumar Rajendram

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