The Scientific Basis of Fatigue
- 1st Edition - October 1, 2025
- Imprint: Academic Press
- Editors: Colin R. Martin, Victor R. Preedy, Vinood Patel, Rajkumar Rajendram
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 4 0 8 0 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 4 0 8 1 - 2
Fatigue is a prevalent problem and adequate treatment is challenging because many conditions, disorders, medications, and lifestyle factors can cause fatigue. The Scientific Ba… Read more
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Request a sales quoteFatigue is a prevalent problem and adequate treatment is challenging because many conditions, disorders, medications, and lifestyle factors can cause fatigue. The Scientific Basis of Fatigue combines evidence-based research and clinical treatment protocols to provide a comprehensive reference to fatigue. This book is divided into seven distinct sections, starting with an introduction section defining the distinctions between physical and mental fatigue. The second and third sections detail the various conditions in both physical and mental fatigue including COVID, Parkinson disease, and depression. The next section reviews the current research on molecular and cellular aspects and models of fatigue. The final two sections review options for diagnosis and treatments for fatigue and provides a detailed resource section for further review.
- Reviews molecular and cellular aspects of chronic fatigue syndrome
- Outlines fatigue in relation to various conditions including diabetes, Parkinson’s disease, and stroke
- Includes mini dictionary of terms and summary points for each chapter
Behavioral scientists, psychologists, psychiatrist, neurologists, health scientists, doctors in primary or secondary care and research scientists. Students in similar fields
Section 1. Setting The Scene And Introductory Chapters
1. Physical fatigue
2. Mental fatigue
Section 2. Fatigue In Different Conditions
3. Myalgic encephalomyelitis/ chronic fatigue syndrome and metabolic phenotypes
4. Fatigue in alcohol use and misuse
5. Fatigue in asthma patients (link in quality of life)
6. Fatigue in cancer diagnosis
7. Fatigue in diabetes
8. Fatigue in heart disease
9. Fatigue in Long COVID
10. Fatigue in Parkinson disease
11. Fatigue in polyneuropathy
12. Fatigue in postoperative scenarios
13. Fatigue in stroke
14. Post-exercise fatigue
15. Fatigue, sleep and sleepiness
16. Fatigue and fibromyalgia
Section 3. Mental Fatigue
17. Cortical activity and links mental fatigue
18. Nutritional and mental fatigue
19. Mental fatigue and pain
20. Mental fatigue in athletes
21. The heart in mental fatigue
22. Linking motor function and mental fatigue
23. Fatigue and mood disorders: the example of depression
Section 4. Molecular And Cellular Aspects and Models
24. Gene Methylation in myalgic encephalomyelitis/chronic fatigue syndrome
25. The mitochondria in myalgic encephalomyelitis/chronic fatigue syndrome
26. Modelling fatigue in rats: investigating high fat diets
27. Modelling fatigue in mice: investigating transforming growth factor-beta
Section 5. Diagnosis and Assessments
28. An overview of clinical tools to evaluate fatigue and their field of application
29. Assessing post-stroke fatigue with different questionnaires
30. Machine learning approaching to detecting fatigue
31. Using an App for assessing real time fatigue
32. The PROMIS Fatigue (MS) 8a inventory
33. Decision trees and fatigue
Section 6. Treating and Managing Fatigue
34. Cognitive behavioral therapy for fatigue
35. Personalised exercise to improve fatigue
36. Managing symptom of fatigue: the example of HIV
37. Treating fatigue with dopaminergic regulator: the example of s (-)-OSU6162
38. Treating fatigue with antiviral medications: the example of chronic fatigue syndrome/myalgic encephalomyelitis
39. Treating fatigue with nutraceuticals and plants: the example of Pinus koraiensis
Section 7. Resources
40. Resources for the study and investigation of fatigue
1. Physical fatigue
2. Mental fatigue
Section 2. Fatigue In Different Conditions
3. Myalgic encephalomyelitis/ chronic fatigue syndrome and metabolic phenotypes
4. Fatigue in alcohol use and misuse
5. Fatigue in asthma patients (link in quality of life)
6. Fatigue in cancer diagnosis
7. Fatigue in diabetes
8. Fatigue in heart disease
9. Fatigue in Long COVID
10. Fatigue in Parkinson disease
11. Fatigue in polyneuropathy
12. Fatigue in postoperative scenarios
13. Fatigue in stroke
14. Post-exercise fatigue
15. Fatigue, sleep and sleepiness
16. Fatigue and fibromyalgia
Section 3. Mental Fatigue
17. Cortical activity and links mental fatigue
18. Nutritional and mental fatigue
19. Mental fatigue and pain
20. Mental fatigue in athletes
21. The heart in mental fatigue
22. Linking motor function and mental fatigue
23. Fatigue and mood disorders: the example of depression
Section 4. Molecular And Cellular Aspects and Models
24. Gene Methylation in myalgic encephalomyelitis/chronic fatigue syndrome
25. The mitochondria in myalgic encephalomyelitis/chronic fatigue syndrome
26. Modelling fatigue in rats: investigating high fat diets
27. Modelling fatigue in mice: investigating transforming growth factor-beta
Section 5. Diagnosis and Assessments
28. An overview of clinical tools to evaluate fatigue and their field of application
29. Assessing post-stroke fatigue with different questionnaires
30. Machine learning approaching to detecting fatigue
31. Using an App for assessing real time fatigue
32. The PROMIS Fatigue (MS) 8a inventory
33. Decision trees and fatigue
Section 6. Treating and Managing Fatigue
34. Cognitive behavioral therapy for fatigue
35. Personalised exercise to improve fatigue
36. Managing symptom of fatigue: the example of HIV
37. Treating fatigue with dopaminergic regulator: the example of s (-)-OSU6162
38. Treating fatigue with antiviral medications: the example of chronic fatigue syndrome/myalgic encephalomyelitis
39. Treating fatigue with nutraceuticals and plants: the example of Pinus koraiensis
Section 7. Resources
40. Resources for the study and investigation of fatigue
- Edition: 1
- Published: October 1, 2025
- Imprint: Academic Press
- No. of pages: 450
- Language: English
- Paperback ISBN: 9780443240805
- eBook ISBN: 9780443240812
CM
Colin R. Martin
Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.
Affiliations and expertise
Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UKVP
Victor R. Preedy
Professor Preedy has been elected as a Fellow to the following Royal Societies: The Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health and Hygiene, the Royal Society for Public Health, the Royal Society of Chemistry, and the Royal Society of Medicine. He was founding Director of the Genomics Centre at King’s College London and held the post from 2006 to 2020. He is a leading expert on the science of health and has a long-standing interest in disease processes, biomarkers, and tissue pathology. He has lectured nationally and internationally. Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.
Affiliations and expertise
Professor, Clinical Biochemistry, King’s College Hospital, London, UK.
Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK.
Visiting Professor at the University of Hull, UK.VP
Vinood Patel
Vinood B. Patel, BSc, PhD, FRSC, is currently Professor in Clinical Biochemistry at the University of Westminster. In 2014 Dr Patel was elected as a Fellow to The Royal Society of Chemistry. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School, NC, USA studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding mitochondrial oxidative stress in neurological disorders and iron dysregulation in diabetes. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to the use or investigation of active agents or components. These books include The Handbook of Nutrition, Diet, and Epigenetics, Branched Chain Amino Acids in Clinical Nutrition, Cancer: Oxidative Stress and Dietary Antioxidants, Toxicology: Oxidative Stress and Dietary Antioxidants, Molecular Nutrition: Vitamins, The Neuroscience of Pain, Cognitive Behavioural Therapy. He is Editor of the ten-volume series Biomarkers in Disease: Methods, Discoveries and Applications.
Affiliations and expertise
Reader, Clinical Biochemistry, University of Westminster, London, UKRR
Rajkumar Rajendram
Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.
Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.
Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.
Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.
Affiliations and expertise
Consultant in Internal Medicine, King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia