
The Scientific Basis of Fatigue
- 1st Edition - October 1, 2025
- Imprint: Academic Press
- Editors: Colin R. Martin, Victor R. Preedy, Vinood Patel, Rajkumar Rajendram
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 4 0 8 0 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 4 0 8 1 - 2
Fatigue is a prevalent problem and adequate treatment is challenging because many conditions, disorders, medications, and lifestyle factors can cause fatigue. The Scientific Ba… Read more

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Request a sales quote- Reviews molecular and cellular aspects of chronic fatigue syndrome
- Outlines fatigue in relation to various conditions including diabetes, Parkinson’s disease, and stroke
- Includes mini dictionary of terms and summary points for each chapter
1. Physical fatigue
2. Mental fatigue
Section 2. Fatigue In Different Conditions
3. Myalgic encephalomyelitis/ chronic fatigue syndrome and metabolic phenotypes
4. Fatigue in alcohol use and misuse
5. Fatigue in asthma patients (link in quality of life)
6. Fatigue in cancer diagnosis
7. Fatigue in diabetes
8. Fatigue in heart disease
9. Fatigue in Long COVID
10. Fatigue in Parkinson disease
11. Fatigue in polyneuropathy
12. Fatigue in postoperative scenarios
13. Fatigue in stroke
14. Post-exercise fatigue
15. Fatigue, sleep and sleepiness
16. Fatigue and fibromyalgia
Section 3. Mental Fatigue
17. Cortical activity and links mental fatigue
18. Nutritional and mental fatigue
19. Mental fatigue and pain
20. Mental fatigue in athletes
21. The heart in mental fatigue
22. Linking motor function and mental fatigue
23. Fatigue and mood disorders: the example of depression
Section 4. Molecular And Cellular Aspects and Models
24. Gene Methylation in myalgic encephalomyelitis/chronic fatigue syndrome
25. The mitochondria in myalgic encephalomyelitis/chronic fatigue syndrome
26. Modelling fatigue in rats: investigating high fat diets
27. Modelling fatigue in mice: investigating transforming growth factor-beta
Section 5. Diagnosis and Assessments
28. An overview of clinical tools to evaluate fatigue and their field of application
29. Assessing post-stroke fatigue with different questionnaires
30. Machine learning approaching to detecting fatigue
31. Using an App for assessing real time fatigue
32. The PROMIS Fatigue (MS) 8a inventory
33. Decision trees and fatigue
Section 6. Treating and Managing Fatigue
34. Cognitive behavioral therapy for fatigue
35. Personalised exercise to improve fatigue
36. Managing symptom of fatigue: the example of HIV
37. Treating fatigue with dopaminergic regulator: the example of s (-)-OSU6162
38. Treating fatigue with antiviral medications: the example of chronic fatigue syndrome/myalgic encephalomyelitis
39. Treating fatigue with nutraceuticals and plants: the example of Pinus koraiensis
Section 7. Resources
40. Resources for the study and investigation of fatigue
- Edition: 1
- Published: October 1, 2025
- Imprint: Academic Press
- No. of pages: 450
- Language: English
- Paperback ISBN: 9780443240805
- eBook ISBN: 9780443240812
CM
Colin R. Martin
VP
Victor R. Preedy
VP
Vinood Patel
RR
Rajkumar Rajendram
Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.
Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.
Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.
Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.