The Role of Sphingolipids in Cancer Development and Therapy

Contributors

Preface

Chapter One. Interdiction of Sphingolipid Metabolism to Improve Standard Cancer Therapies

1 Introduction

2 Sphingolipids and Cytotoxic Chemotherapies

3 Sphingolipids and Radiation Therapy

4 Sphingolipids and Targeted Anticancer Agents

5 Concluding Remarks

References

Chapter Two. Diverse Functions of Ceramide in Cancer Cell Death and Proliferation

1 Structure and Metabolism of Ceramide

2 Distinct Functions of CerS1–6

3 Novel Ceramide–Protein Interactions that Regulate Ceramide Metabolism and Signaling

4 Clinical Relevance of Ceramide Metabolism and Signaling in Cancer Pathogenesis, Therapy, or Drug Resistance

5 Ceramide/Sphingosine-Based Anticancer Therapeutics

6 Conclusions

References

Chapter Three. Ceramide Glycosylation Catalyzed by Glucosylceramide Synthase and Cancer Drug Resistance

1 Introduction

2 Ceramide Glycosylation and GEMs

3 Ceramide Glycosylation and Cancer Drug Resistance

4 Targeting Ceramide Glycosylation to Reverse Drug Resistance

5 Prospective

References

Chapter Four. Use of Acid Sphingomyelinase for Cancer Therapy

1 Introduction

2 Involvement of ASM in Stress Response, Apoptosis, and Cancer Cell Resistance

3 Use of Exogenous ASM as an Adjunct in Cancer Therapy

4 Conclusions and Future Directions

References

Chapter Five. Hypoxia, Therapeutic Resistance, and Sphingosine 1-Phosphate

1 The Hypoxia-Inducible Factors Family: Regulation, Role in Cancer and Therapeutic Implication

2 What Does Sphingosine 1-Phosphate Signaling Have to Do with Hypoxia?

3 Sphingosine 1-Phosphate Signaling as a Target for AntiHypoxic Strategy?

4 Concluding Remarks

References

Chapter Six. Therapeutic Potential of Targeting SK1 in Human Cancers

1 Introduction to Sphingolipid Metabolism

2 Sphingosine Kinase: A Regulator of the Sphingolipid Signaling

3 Role of SK1 in Cancer Progression

4 Therapeutic Potential of SK1 Inhibition

5 FTY720: A Novel Clinically Applicable SK1 Inhibitor

6 Conclusions and Clinical Perspective

References

Chapter Seven. Sphingosine Kinase 1 in Cancer

1 Introduction

2 SK1 is an oncogene

3 SK1/S1P signals for tumor growth and spread

4 Conclusion

References

Chapter Eight. Natural Products as Platforms for the Design of Sphingolipid-Related Anticancer Agents

Abbreviations

1 The Role of Sphingolipids in Cancer

2 Fungal Metabolites as Inhibitors of SL Biosynthesis

3 Deoxysphingolipids of Marine Origin

4 Jaspine B, a Marine Heterocyclic Sphingoid

5 Other Heterocyclic Natural Sphingoids

6 α-Galactosylceramides and Structural Modifications Thereof

7 Concluding Remarks

References

Index