The Plasma Proteins V3

Structure, Function, and Genetic Control

2nd Edition - December 28, 1977

Editor: Frank Putnam

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 1 6 1 4 6 - 6

The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume III is an eight-chapter treatise that describes the plasma proteins in a systematic… Read more

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The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume III is an eight-chapter treatise that describes the plasma proteins in a systematic integrated manner. This book presents first the perspectives and global outlook at plasma proteins, followed by a series of chapters on the well-characterized major proteins, with particular emphasis on immunoglobulins. Other chapters are devoted to the integrated systems of plasma proteins, especially their structure, function, and genetic control. A chapter describes the plasma protein fractionation. The remaining chapters introduce the clinical relevance of the plasma proteins. This book will be of great value to biologists, geneticists, clinicians, and researchers.

List of Contributors

Preface

Contents of Other Volumes

1 Immunoglobulins I. Structure

I. Introduction

II. Chemical, Physical, and Biological Properties of Normal and Pathological Human Immunoglobulins

III. Principles of Immunoglobulin Structure

IV. Primary Structure of Human Light Chains

V. Primary Structure of the Variable Region of Heavy Chains

VI. Primary Structure of the Constant Region of Human Heavy Chains

VII. Conformation and Three-Dimensional Structure

VIII. Other Proteins and Polypeptide Chains Associated with Immunoglobulins

IX. Coda

References

2 Immunoglobulins II. Antibody Specificity and Genetic Control

I. Introduction

II. Immunoglobulin Structure and Antibody Specificity

III. Mutations, Deletions, Duplications, Recombinations, and Permutations of Immunoglobulin Structure

IV. Biological Properties of the C Region of Immunoglobulins

V. Molecular Aspects of Biosynthesis and Assembly of Immunoglobulins

References

Note Added in Proof

3 Immunoglobulins III. Comparative Biochemistry and Evolution

I. Introduction

II. Nomenclature and Criteria for Classification of Animal Immunoglobulins

III. Comparative Biochemistry of Animal Immunoglobulins

IV. Structure and Evolution of Light Chains

V. Structure and Evolution of Animal Heavy Chains

VI. Evolution of the Immunoglobulin Domain

References

4 Antibodies with Molecular Uniformity

I. Introduction

II. Evidence for Restricted Heterogeneity

III. Factors Controlling the Occurrence of Antibodies with Uniform Properties

IV. Sources of Antibodies with Restricted Heterogeneity

V. Amino Acid Sequence of Light and Heavy Chains from Homogeneous Antibodies

VI. Use of Homogeneous Antibodies to Study the Inheritance of Idiotypy

VII. Conclusions and Summary

References

5 The Group-Specific Component (Gc) System

I. Introduction

II. Detection, Purification, and Physical Properties

III. Chemical Composition and Subunit Structure

IV. Genetic Variation and Geographic Distribution

V. Function, Biosynthesis, Metabolism, and Phylogenetic Aspects

VI. Coda

References

6 Circulating Hormones

I. Introduction

II. Hormones of Pancreatic Origin

III. Pituitary Hormones

IV. Nonpituitary Polypeptide Hormones

V. Nonpolypeptide Hormones

References

7 Blood Coagulation Proteins

I. General Introduction

II. Isolation and Characterization of the Various Coagulation Factors

III. Hereditary Nature of the Clotting Disorders

IV. Molecular Mechanisms of Blood Coagulation

V. Regulation of Coagulation

References

8 Plasma Protein Fractionation

I. Introduction

II. Principles of Protein Separation

III. Well-Characterized Plasma Proteins

IV. Distribution of Proteins in the Fractions of the Alcohol and Rivanol-Ammonium Sulfate Procedures

V. Purification Methods for Individual Plasma Proteins

References

Subject Index