The Paradox of the Immune System
Protection, Chronic Inflammation, Autoimmune Disease, Cancer, and Pandemics
- 1st Edition - August 3, 2022
- Author: Louis J. Catania
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 1 8 7 - 6
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 1 8 8 - 3
The Paradox of the Immune System: Protection, Inflammation, Autoimmune Disease and Beyond provides a provocative approach to immunology as a "double-edged sword." While it is our… Read more
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Request a sales quoteThe Paradox of the Immune System: Protection, Inflammation, Autoimmune Disease and Beyond provides a provocative approach to immunology as a "double-edged sword." While it is our greatest protector, it is also the cause of chronic inflammation that leads to autoimmune disease, cancer and infectious diseases like COVID-19. Sections cover the basic science of immunology and its intimate genetic associations, biomedical hypotheses asserting immunology as the basis of all human diseases, and elaborate on immunology as "the enemy within us." This engaging, original approach to a science so personal provides new and invaluable understanding on the bioscience that controls our lives.
- Written in an expository style that allows for maximum understanding of the complex science presented
- Presents the unfolding of immunology from a natural (innate) system into an adaptive system leading to chronic inflammation and ultimate disease
- Provides readers with a unique perspective on health, wellness and disease
Researchers in Immunology, Autoimmunity, Virology and Cancer research. Health related students at all levels, general practitioners, administrator and interested general public who are seeking a general understanding of immunology and its benefits, but more so its related implications in autoimmune disease, cancers and COVID-19
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of Figures
- List of Tables
- Louis J. Catania, O.D., F.A.A.O., D.Sc. (Hon.)
- Preface
- Acknowledgements
- Three reasons to understand the immune system
- First…
- Second…
- Third…
- Section 1. Our friendly immune system
- Section 1 Our friendly immune system
- 1. Introduction
- 1. The innate (aka “natural”) immune system and immunity
- 1. Some simple definitions of the immune system, immunology, the immune response, and immunity
- 2. Development (embryology and beyond) of the immune system [1]
- 3. The gross and microanatomy of the immune system
- 4. Innate (aka “natural”) immune response and active immunity [7]
- 5. Brief research summaries on the innate immune system
- Chapter highlights (key points and paradoxical-related information)
- 2. The adaptive (aka “acquired”) immune system: from friend to foe
- 1. The path to “dysregulation”
- 2. Acute inflammation
- 3. Clinical considerations in acute inflammation
- 4. Using the adaptive immune response to help and prevent disease
- 5. The path to chronic inflammation
- 6. Brief research summaries on the innate and adaptive immune system
- Chapter highlights (key point and paradoxical-related information)
- 3. Genetics and genomics
- 1. Introduction
- 2. Basic science of genetics
- 3. Immunogenetics
- 4. Immunogenomics
- 5. Genetics and genomics by the numbers
- 6. The Human Genome Project [14]
- 7. Precision (personalized) medicine and prevention [15]
- 8. XCI (lyonization)
- 9. The “microbiome”
- 10. Epigenetics [26]
- 11. Cytogenetics
- 12. Big data analytics in genetics and genomics [32]
- 13. Brief research summaries on genetics and genomics
- Chapter highlights on genetics and genomics
- Section 2. The enemy within us
- Section 2 The enemy within us
- 1. Introduction
- 4. Chronic inflammation: “Enemy #1”
- 1. Introduction
- 2. Causes (etiologies) of chronic inflammation [2]
- 3. Advancing adaptive immunity (from acute to chronic inflammation)
- 4. Differences in chronic inflammation from acute inflammation
- 5. Some (but not all by a long shot) disease categories associated with chronic inflammation [7]
- 6. Clinical diagnosis and treatment of chronic inflammation
- 7. Neural downregulation of the immune system and chronic inflammation
- 8. Brief research summaries on chronic inflammation
- Chapter highlights (key points and paradoxical-related information)
- 5. Autoimmune disease: when self becomes the villain
- 1. Introduction
- 2. Female predilection for autoimmune disease
- 3. Theories on the pathogenesis of autoimmune diseases [7]
- 4. Classification of autoimmune diseases
- 5. General clinical considerations with autoimmune diseases [21]
- 6. “Top 10” autoimmune diseases (clinical descriptions, diagnosis, and treatment options) [28,29]
- 7. General therapeutics considerations with autoimmune diseases
- 8. Therapeutic (cellular and genetic) procedures
- 9. Brief research summaries on autoimmune diseases
- Chapter highlights (key points and paradoxical-related information)
- 6. Cancer: immunology's cruelest enemy and greatest challenge
- 1. Introduction
- 2. “Cancering”
- 3. The incidence and prevalence of cancer
- 4. Description and etiologies of cancers
- 5. Clinical presentations in cancers [26]
- 6. Treatment considerations in cancer
- 7. Brief research summaries on cancers
- Chapter highlights (key points and paradoxical-related information)
- 7. Immunology: The science of pandemics, infectious disease and COVID-19
- 1. Introduction
- 2. Background considerations
- 3. Incidence and prevalence of COVID-19
- 4. Pathogenesis, immunologic, and immunogenic considerations for SARS-CoV-2
- 5. Clinical considerations for coronavirus (SARS-CoV-2) infection
- 6. Immunoinformatics (computational immunology) [68]
- 7. Epidemiology and public health considerations in COVID-19
- 8. Brief research summaries on infectious diseases and COVID-19
- Chapter highlights (key points)
- Epilogue
- Glossary
- Index
- No. of pages: 284
- Language: English
- Edition: 1
- Published: August 3, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323951876
- eBook ISBN: 9780323951883
LC
Louis J. Catania
Dr. Louis J. (Lou) Catania is an internationally acclaimed educator, and a recognized expert in eye care, health care, artificial intelligence (AI) and immunology. He has authored over 160 journal articles and 12 textbooks, one of which, “Primary Care of the Anterior Segment” received the Baron's Five Star (highest) rating for a medical textbook. He is currently a lecturer with the University of North Florida, Department of Continuing Education, Osher Lifelong Learning Institute; and a visiting Professor at Salus University, College of Health Sciences. During his 52-year clinical and academic career he has taught and lectured extensively worldwide. Dr. Catania’s career in healthcare started as an optometric physician with an interest in corneal immunology. That interest grew into postdoctoral pursuits over the past 35 years with studies in virology, immunology and public health (University of Rochester, UPenn, Stanford Continuing Studies and MIT OpenCourseWare). He has dedicated himself to research, teaching, and writing with his 3 most recent books on AI in healthcare, AI in immunology, and an inspired new text on the mercurial nature of the human immune system (“The Paradox of the Immune System”). Dr. Catania’s professional accomplishments in eyecare, healthcare and immunology have produced countless honors and awards including 2 Honorary Doctor of Science degrees; Distinguished Faculty Scholar at 3 academic institutions; induction into the National Optometry Hall of Fame; and innumerable domestic and international keynote and commencement addresses. In his personal time, Dr. Catania is an active volunteer with the National Park Service; a sea turtle patrol monitor in his beach community; and involved in multiple environmental, humanitarian and human welfare agencies.
Affiliations and expertise
Salus University, College of Health Sciences; University of North Florida, Osher Lifelong Learning InstituteRead The Paradox of the Immune System on ScienceDirect