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The Pancreatic Beta Cell
- 1st Edition, Volume 95 - February 20, 2014
- Editor: Gerald Litwack
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 0 0 1 7 4 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 0 4 4 0 - 1
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone rese… Read more
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Request a sales quoteFirst published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.
The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed.
This volume focuses on the pancreatic beta cell.
- Expertise of the contributors
- Coverage of a vast array of subjects
- In depth current information at the molecular to the clinical levels
- Three-dimensional structures in color
- Elaborate signaling pathways
Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.
Former EditorsContributorsPrefaceChapter One: Metabolic Regulation of Insulin SecretionAbstract
1 Introduction
2 Glucose Metabolism and Insulin Secretion
3 Fatty Acid Metabolism and Insulin Secretion
4 Amino Acid Metabolism and Insulin Secretion
5 Association of Nutrient Metabolism with Pancreatic β-Cell Dysfunction
6 Conclusions
Chapter Two: Proinsulin Entry and Transit Through the Endoplasmic Reticulum in Pancreatic Beta CellsAbstract
1 Overview of Insulin Biosynthesis in Pancreatic Beta Cells
2 Proinsulin Entry into the ER
3 Proinsulin Transit Through the ER
4 Conclusion and Perspective
Acknowledgments
Chapter Three: Metabolism–Secretion Coupling and Mitochondrial Calcium Activities in Clonal Pancreatic β-CellsAbstract
1 Introduction
2 The Importance of Mitochondria to β-Cell Function
3 Oxidative Metabolism of β-Cells
4 Mitochondrial Ca2 + and Energy Metabolism
5 Ca2 + Handling in β-Cells
Acknowledgments
Chapter Four: Metabolic Syndrome and Ionic Channels in Pancreatic Beta CellsAbstract
1 Introduction
2 A Rapid Fly on Metabolic Syndrome
3 Physiology of Pancreatic Islets in Glucose Homeostasis
4 Physiology and Pathophysiology of Ionic Channels
5 Concluding Remarks
Chapter Five: The Beta Cell ImmunopeptidomeAbstract
1 Introduction
2 Autoantigens in T1D
3 Antigen Processing
4 Identifying T Cell Epitopes in T1D
5 Peptide-Based Intervention and the Role of Small Molecules
6 Advances in Mass Spectrometry for the Identification of PTMs
7 Conclusions
Chapter Six: Autophagy and Pancreatic β-CellsAbstract
1 Introduction
2 Autophagy
3 Autophagy and Pancreatic β-Cell Homeostasis
4 Adaptive Autophagy in Pancreatic β-Cell
5 Autophagy and Diabetes
6 Modulation of Autophagy as Therapeutic Strategy
7 Conclusions and Future Directions
Acknowledgments
Chapter Seven: The Somatostatin Receptor in Human Pancreatic β-CellsAbstract
1 Introduction
2 SST in Pancreatic Islets
3 Regulation of SST Secretion from Pancreatic δ-Cells
4 Effects of Exogenous SST on Hormone Secretion from Pancreatic Islets
5 Cellular Mechanisms Underlying SST Inhibition of Pancreatic Hormone Secretion
6 SSTRs in Pancreatic Islet Cells
7 Physiological Role of SST Signaling in Pancreatic Islets
8 SST and δ-Cells in Diabetes Mellitus
9 Clinical Uses of SSTR Agonists and Pancreatic Islets
10 Conclusions and Future Directions
Acknowledgments
Chapter Eight: Modulation of the Pancreatic Islet-Stress Axis as a Novel Potential Therapeutic Target in Diabetes MellitusAbstract
1 Introduction
2 Factors and Conditions Predisposing to the Development of Diabetes Mellitus
3 Current Options and Concepts for the Prevention and Treatment of Diabetes Mellitus
4 Implication of the Pancreatic Islet-Stress Axis in Diabetes Mellitus: A Potential Target for Prevention and Therapy
5 Conclusions and Future Directions
Acknowledgments
Chapter Nine: Regenerative Medicine for Diabetes: Differentiation of Human Pluripotent Stem Cells into Functional β-Cells In Vitro and Their Proposed Journey to Clinical TranslationAbstract
1 Introduction
2 Diabetes and Its History
3 Differentiation Protocols for Human Pluripotent Stem Cells to β-Cells
4 hESC/hPSC-Derived Beta Islets-Based Cell Therapy for Diabetes
5 Conclusion
Chapter Ten: The Calcium-Sensing Receptor and β-Cell FunctionAbstract
1 Introduction
2 The Calcium-Sensing Receptor (CaSR)
3 Effects of CaSR on β-Cell Adhesion, Coupling, and Communication
4 Effects of the CaSR on Insulin Secretion
5 Effects of the CaSR on β-Cell Proliferation
6 The CaSR and Diabetes Mellitus
7 Conclusion
Acknowledgment
Chapter Eleven: Cellular Inhibitor of Apoptosis Protein-1 and Survival of Beta Cells Undergoing Endoplasmic Reticulum StressAbstract
1 Introduction
2 ER Stress in the Balance Between Cell Death and Survival
3 ER Stress and Lipotoxicity in Beta Cell Failure
4 Role of cIAP1 in Beta Cell Survival Under ER Stress
Acknowledgments
Chapter Twelve: β-Cell Responses to Nitric OxideAbstract
1 Introduction
2 Cytokine-Induced Damage
3 Mechanisms of Nitric Oxide-Induced β-Cell Death: Apoptosis or Necrosis?
4 Recovery from Nitric Oxide-Induced Damage
5 Conclusions
Chapter Thirteen: Activated Protein C and Its Potential Applications in Prevention of Islet β-Cell Damage and DiabetesAbstract
1 Introduction
2 Protein C and Activated Protein C
3 Pancreas and Pancreatic Islet β-Cell Function
4 APC and β-Cell Preservation in Diabetes
5 Conclusions
Chapter Fourteen: Zinc and Its Transporters, Pancreatic β-Cells, and Insulin MetabolismAbstract
1 Introduction
2 Zinc and Its Transporters in Insulin Synthesis and Secretion in Pancreatic β-Cells
3 Zinc Transporters and their Physiological Roles and Contributions to Insulin Metabolism and Glucose Homeostasis: Studies in Mouse Knockout Models of Zinc Transporters
4 Zinc and Its Transporters in the Development of Diabetes in Humans
5 Conclusions and Future Directions
Acknowledgments
Chapter Fifteen: The NOTCH Pathway in β-Cell Growth and DifferentiationAbstract
1 Introduction
2 Role of the NOTCH Pathway in Pancreas Development
3 Evidence for Reactivation of the NOTCH Pathway in Adult Pancreatic Cells
4 Effect of the NOTCH Pathway on Proliferation, Dedifferentiation, and Redifferentiation of Cultured Human β-Cell-Derived Cells
Acknowledgments
Chapter Sixteen: Roles of HNF1α and HNF4α in Pancreatic β-Cells: Lessons from a Monogenic Form of Diabetes (MODY)Abstract
1 Introduction
2 Clinical Features of HNF1α Diabetes (MODY3)
3 Functional Regulation of β-Cells by HNF1α
4 HNF1α Regulates β-Cell Growth
5 HNF4α Gene and Diabetes
6 Functional Role of HNF4α in β-Cells
7 Anks4b Is a Novel Target of HNF4α in β-Cells
8 Concluding Remarks
Acknowledgments
Chapter Seventeen: Role of the Mammalian Target of Rapamycin (mTOR) Complexes in Pancreatic β-Cell Mass RegulationAbstract
1 Introduction
2 Pancreatic β-Cell Mass
3 Structure of mTORC1/mTORC2 Complexes
4 Insulin and mTORC2 Signaling in Pancreatic β-Cells
5 Integration of Insulin, Energy, and Stress Signals by mTORC1
6 Conclusions and Future Directions
Index
- No. of pages: 520
- Language: English
- Edition: 1
- Volume: 95
- Published: February 20, 2014
- Imprint: Academic Press
- Hardback ISBN: 9780128001745
- eBook ISBN: 9780128004401
GL
Gerald Litwack
Dr. Litwack has authored 3 textbooks on biochemistry and hormones (one with John Wiley & Sons and 2 with Academic Press/Elsevier) and he has edited more than 70 volumes in the Vitamins & Hormones series (Academic Press/Elsevier); he has edited 14 volumes entitled Biochemical Actions of Hormones (Academica Press); He has edited (with David Kritchevsky) Actions of Hormones on Molecular Processes (Academic Press)
Affiliations and expertise
Emeritus Founding Chair and Professor, Geisinger Commonwealth School of Medicine, United States
Emeritus Professor, Rutgers University, United StatesRead The Pancreatic Beta Cell on ScienceDirect