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Elsevier

The Neuroscience of Spinal Cord Injury

  • 1st Edition - May 27, 2022
  • Latest edition
  • Editors: Rajkumar Rajendram, Victor R. Preedy, Colin R. Martin
  • Language: English

Diagnosis and Treatment of Spinal Cord Injury will enhance readers’ understanding of the complexities of the diagnosis and management of spinal cord injuries. Featuring chapte… Read more

Description

Diagnosis and Treatment of Spinal Cord Injury will enhance readers’ understanding of the complexities of the diagnosis and management of spinal cord injuries. Featuring chapters on drug delivery, exercise, and rehabilitation, this volume discusses in detail the impact of the clinical features, diagnosis, management, and long-term prognosis of spinal cord injuries on the lives of those affected. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand spinal cord injuries.

Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers’ understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries.

Key features

Diagnosis and Treatment of Spinal Cord Injury:

  • Covers both the diagnosis and treatment of spinal cord injury
  • Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding
  • Features chapters on epidemiology and pain
  • Includes MRI usage, biomarkers, and stem cell and gene therapy for management of spinal cord injury
  • Discusses pain reduction, drug delivery, and rehabilitation

Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury:

  • Summarizes the neuroscience of spinal cord injury, including cellular and molecular biology
  • Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding
  • Features chapters on signaling and hormonal events
  • Includes plasticity and gene expression
  • Examines health and stress behaviors after spinal cord injury

Readership

Designed for research and teaching purposes, it is suitable for neuroscientists, neurologists, clinicians, health scientists, public health workers, doctors, and research scientists. It is valuable as a personal reference book and also for academic libraries that covers the domains of neurology and health sciences. It is also suitable for undergraduates, postgraduate, lecturers and academic professors

Table of contents

Diagnosis and Treatment of Spinal Cord Injury:I. Setting The Scene: Introductory Chapters1. Outcomes of traumatic spinal cord injury in low-resource settingAvital Yohann, Laura Purcell and Anthony Charles2. Spine injuries associated with spinal cord injurySalomón Flórez Jiménez, Etienne Bourassa-Moreau, Jean-Marc Mac-Thiong and Gilles Maurais3. Body, action and space representations in people affected by spinal cord injuriesMichele Scandola4. Methods for treating pain and painful syndromes in spinal cord injury: medications, therapies, interventions, and neuromodulationJames J. Bresnahan

II. Clinical Features Of Spinal Injury 5. Factors Contributing To Pressure Injuries In Traumatic Spinal Cord InjuryGabrielle Gour-Provencal and Jehane Dagher6. Venous thromboembolismin spinal cord injury Rodrigo Lanna de Almeida7. Osteoporosis-related fractures: what they are and how they occur following spinal cord injuryAna Paula Champs8. Brain atrophy and white matter in compression injury to the spinal cordAngela Bernabeu-Sanz and Eduardo Fernández-Jover9. Spasticity in spinal cord injuryRamiro Palazón-García10. Falls among individuals living with spinal cord injuryL. Rice11. Infections and spinal cord injury: Covid 19 and beyondE. López-Dolado12. Treating sleep problems in spinal cord injuryDavid J. Berlowitz and Marnie Graco

III. Diagnosis and Evaluation13. Biomarkers in spinal cord injuryTania Cristina Leite de Sampaio e Spohr14. Quality of life tools for spinal cord injured peopleSebastian Salvador-De La Barrera, Ibone Gimenez-Jimenez, Manuel Astray-Lopaz, Antonio Rodriguez-Sotillo, M. Elena Ferreiro-Velasco and Antonio Montoto-Marqués Sr.15. S100 in spinal cord injuryGeorge Alexiou16. Balance measures and assessments in spinal cord injury: a narrativeKristin Musselman and Jean-Francois Lemay

IV. Treatments: Experimental and Clinical17. Surgical management of acute spinal cord injury in emergency departmentsFederico Fusini, Angela Coniglio, Alessandro Rava, Salvatore Risitano, Alessandro Massè and Massimo Girardo18. Spinal cord epidural stimulation for autonomic nervous system control April Herrity19. Treating spinal cord injury with implanted spinal cord stimulatorsHengze You, Y.-P. Zheng and Monzurul Alam20. Bowel dysfunction in spinal cord injury M. Elena Ferreiro-Velasco, Antonio Montoto-Marqués Sr., Maria Eugenia Díaz-Recarey, Renato Vilas-Boas, Sebastian Salvador-De La Barrera and Antonio Rodriguez-Sotillo21. Management of lower urinary tract dysfunction Noritoshi Sekido22. Bed and mattress for preventing pressure injuries after spinal cord injuryAnnie Levasseur23. Nerve and tendon transfers in tetraplegia: a new narrative Federico Fusini, Paolo Titolo, Stefano Artiaco, Bruno Battiston, Salvatore Risitano and Alessandro Massè24. Gemini-supported spinal cord transplantation for the treatment of chronic spinal paralysisSergio Canavero25. Chondroitinase ABC I as a novel candidate for reducing damage in spinal cord injuryKhosrow Khalifeh26. Phenol neurolysis for the management of spasticity in people with spinal cord injuryRadha Korupolu and Lavina Jethani27. Anti-repulsive guidance molecule-a antibody (RGMa) treatment in spinal cord injuryToshihide Yamashita28. Mitochondrial biogenesis for the treatment of spinal cord injuryR. G. Schnellmann, Epiphani Simmons, Natalie Scholpa and Joshua Crossman29. Exploring the exogenous and endogenous effects of melatonin on spinal cord injuryYonggeun Hong, Dewan Sumsuzzman and Kanghui Park30. High-intensity interval training in spinal cord injuryByron Lai, Jereme Wilroy, and Gordon Fisher31. Stem cells and chronic spinal cord injury: overviewJ. D. Ciacci32. Gene therapy in spinal cord injury Simon O'Carroll and Connor Clemett33. Curcumin usage inflammation and spinal cord injuryK.-T. Kim34. Use of (-)-epigallocatechin-3-gallate on spinal cord injury ali reza Khalatbary35. Vitamin D supplementation for active individuals with spinal cord injury Kelly Pritchett, Brianna Rice and Sophia Berg36. Corticospinal tract regeneration after spinal cord injury: implications for treatment and recoveryP. Lu37. Trophic factors in patients with spinal cord injuryJ. Quintanar

V. Rehabilitation in Spinal Injury38. Spinal cord injury: Multiple Family Group (MFG) education and supportDENNIS g. Dyck, Crystal Lederhos Smith and Bruce Becker39. Spinal cord injury rehabilitation: linking service delivery and community integrationLinda Barclay and Gillean Hilton40. Rehabilitation in spinal cord injury: Exercise and testing for cardiorespiratory endurance and musculoskeletal fitnessKerri A. Morgan, Kelly L. Taylor, and Susan Tucker41. Community based activity-based therapy for spinal cord injuries rehabilitationNatalia Padula and Camila Quel De Oliveira42. Rehabilitation and the Self-Management App: spinal cord injuryBen Mortenson, Gurkaran Singh, Megan MacGillivray, Ethan Simpson and Bonita Sawatzky43. Biomaterials and spinal cord injury and rehabilitation: a new narrative Filippo Rossi, Giuseppe Perale and Elisa Lacroce44. Support in spinal cord injury: a focus on roboticsAngel Gil-Agudo and Guillermo Asín-Prieto

VI. Resources45. Research and ResourcesRajkumar Rajendram

Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury:I. Setting The Scene and Introductory Chapters1. Causes of spinal injury: motor vehicle accidents and beyond Joji Inamasu2. MRI findings in spinal cord injury during acute and chronic phasesSyed Ather Enam, Kiran Aftab, Namrah Aziz, Batool Mujtaba, Asma Akbar Ladak and Fatima Mubarak3. Exercise programs in spinal cord injuryJeongmin Lee, Dong-il Kim and J. Jeon4. Use of anodal transcranial direct current stimulation: features, facets and applications to incomplete spinal cord injuryAmanda Vitória Lacerda de Araujo5. Neuromodulation and restoration of motor responses after severe spinal cord injury G. Taccola6. Rehabilitation and wheelchair users after spinal cord injury: an overview Marcelo Riberto, Ligia Jia Lin Wu and Daniel Rubio de Souza

II. Cellular and Molecular Aspects of Spinal Injury7. Gene expression, bone loss and spinal cord injuryA. Zamarioli8. Sperm DNA fragmentation and its relevance to men with spinal cord injuryS. Johnston9. Cytokines and spinal cord injuryJesús Amo-Aparicio and Clara Penas10. Interleukin-10, vascular pathology in traumatic cervical Spinal cord injuryMichael G. Fehlings11. Protein Degradome in Spinal Cord InjuryS. Bsat, Hani Chanbour, Ali Amine, Charbel Moussalem, Mohamad Nabih El Housheimy, Sarah Kawtharani, Adham Halaoui, Firas H. Kobaissy, Safwan Alomari and Ibrahim Omeis12. Proteomics of Pressure Ulcers in Spinal cord injuryM. Barderas13. Innate immune responses of glia and inflammatory cells in spinal cord injuryStella Elkabes, Lun Li, Cigdem Acioglu and Robert Heary14. The role of oxidative stress in spinal cord injury animal models: a focus on nuclear factor erythroid-2 related factor 2Fernando da Silva Fiorin, Caroline Cunha do Espírito-Santo and L.F.F. Royes15. Novel agent ONO-2506 suppresses astrocytic activation and attenuates post-spinal cord injury painHiroyuki Ishiguro and Takashi Kaito16. Histology, neural tissue loss and compression-induced spinal cord injuryJaroslav Pavel17. Remodeling mitochondrial transport and cellular energetics in axonal regeneration and spinal cord injuryNing Huang and Zu-Hang Sheng18. Neurotrophins and their Role in Axonal Outgrowth Following Spinal Cord InjuryDarren Svirskis, Anusha Dravid and Simon O'Carroll19. The neuroscience of transient receptor potential vanilloid type 4 (TRPV4) and spinal cord injuryI. Han and Hemant Kumar20. Autoantibodies in spinal cord injuryDaniel Garcia-Ovejero, Lukas Grassner, Eduardo Molina-Holgado and Angel Arevalo-Martin21. Calpain role in the pathophysiology of spasticity after spinal cord injuryFrédéric Brocard22. Targeting mTOR Signaling to Promote Autophagy for Functional Recovery after Spinal Cord InjuryNadia Al-Sammarraie and Swapan K. Ray23. Tertiary damage: Hippocampal and brain changes after spinal cord injuryFlorencia Labombarda

III. Physiological and Metabolic Effects24. Hormonal events and spinal cord injury: a focus on vasopressin and natriuretic peptideCharles Hubscher25. Linking sensorimotor plasticity, the motor cortex and spinal cord injuryR. Nardone26. Bone mass and spinal cord injury: risk of fractureIfaz T. Haider, Narina Simonian, Thomas Schnitzer and W. Brent Edwards27. Functional and morphological re-organization of the brain following spinal cord injury : Insights from MRIMaria M. D'Souza, Jeanne D'Souza, Prabhjot Kaur and Pawan Kumar28. Cardiometabolic changes and upper extremity exercise as an augmentative strategy in spinal cord injuryBenjamin Scoblionko, Patricia Orme, James Pendleton, Roger Liu and James J. Bresnahan29. Electrophysiological outcome measures in spinal cord injury: a new narrative Radha Korupolu, Argyrios Stampas, Sudha Tallavajhula and Lumy Sawaki30. Features and Physiology of Spinal Stretch Reflex Pathways in People with Chronic Spinal Cord InjuryAiko K. Thompson and Thomas Sinkjær31. Metabolic syndrome iin spinal cord injury: impact on healthArcangelo Barbonetti, Chiara Castellini, Sandro Francavilla, Felice Francavilla and Settmio D’Andrea32. Body composition and spinal cord injuryKatherine Jane Desneves, Nicole Kiss, Robin Daly and Leigh Ward33. Energy requirements and spinal cord injuryKatherine Jane Desneves, Nicole Kiss, Robin Daly and Leigh Ward34. Virtual walking and spinal cord injury neuropathic painElizabeth Richardson and Zina Trost35. Cervical spinal cord injury and thermoregulatory processes: a new narrativeIbrahim Omeis36. Spinal cord injury and the gut microbiotaPhillip G. Popovich and Kristina A. Kigerl

IV. Behavioural and Psychological Effects37. Risk factors and predictors of depression after spinal cord injury: emphasis on the inflammatory processCaroline Cunha do Espírito-Santo, Fernando da Silva Fiorin and L.F.F. Royes38. Spirituality, hope, and resilience in the recovery and adaptation process following spinal cord injuryKate Jones and Grahame Simpson39. Wellness intervention for spinal cord injuriesStephanie L. Silveira, Emma Richardson and Robert W. Motl40. Sexual satisfaction and spinal cord injurySeçil Taylan41. Depressive symptoms in rehabilitation, spinal cord injurySwati Mehta42. Self-Harm behaviors in Patients with Spinal Cord Injuries: From Nonadherence to SuicideMaggi Budd, Herb Ames and John Bradley

Product details

  • Edition: 1
  • Latest edition
  • Published: May 27, 2022
  • Language: English

About the editors

RR

Rajkumar Rajendram

Dr Rajkumar Rajendram is a clinician-scientist with expertise in internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St Thomas’ Medical School, King’s College London, in 2001, where he received several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram completed specialist training in acute and general medicine in Oxford and subsequently held a Consultant appointment in Acute General Medicine at the John Radcliffe Hospital, Oxford. He also trained in anaesthesia and intensive care in London, including advanced training in regional anaesthesia and intensive care, and subsequently held a Consultant appointment in Intensive Care, Anaesthesia and Peri-operative Medicine at the Royal Free London Hospitals.

His postgraduate training has spanned internal medicine, anaesthesia, intensive care and point-of-care ultrasound (POCUS). He was awarded Fellowship of the Royal College of Anaesthetists in 2009, Fellowship of the Faculty of Intensive Care Medicine in 2013, and the European Diploma in Intensive Care Medicine in 2014. He is a Fellow of both the Royal College of Physicians of Edinburgh and the Royal College of Physicians of London.

Dr Rajendram is currently a Consultant at King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, and holds a joint appointment as Associate Professor in the Research Unit, Department of Medical Education, at King Saud bin Abdulaziz University for Health Sciences.

His multidisciplinary clinical background has informed his research interests in nutrition, fluid management and fluid balance in health and disease, particularly in acutely and critically ill patients. His research has also addressed POCUS, COVID-19 phenotypes and nutritional support in illness. Dr Rajendram has contributed extensively to medical research and education and has authored more than 400 textbook chapters, review articles, peer-reviewed papers and conference abstracts.

Affiliations and expertise
Consultant, Medical Protocol Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia & Joint Appointment Associate Professor, Research Unit, Department of Medical Education, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

VP

Victor R. Preedy

Victor R. Preedy, BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC, FRSM, is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He also holds an Honorary Professorship at the University of Suffolk and served as the long‑term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy graduated with an Honours Degree in Biology and Physiology with Pharmacology and later obtained his PhD from the University of London. He subsequently received Membership of the Royal College of Pathologists and later earned his second doctorate (DSc) in recognition of his contributions to protein metabolism. He is a Fellow of the Royal Society of Medicine, the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health and Hygiene, the Royal Society for Public Health, and the Royal Society of Chemistry. Professor Preedy has conducted research while affiliated with Imperial College London, the School of Pharmacy (now part of University College London), and the MRC Centre at Northwick Park Hospital. He has collaborated widely with international research groups in Finland, Japan, Australia, the USA, and Germany. His longstanding academic interests include health and well‑being. He has published more than 750 works, including peer‑reviewed research articles, abstracts, symposium presentations, reviews, and edited books.

Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK; Visiting Professor, University of Hull, UK

CM

Colin R. Martin

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.
Affiliations and expertise
Visiting Professor of Perinatal Wellbeing, Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK