The Neuroscience of Pain, Anesthetics, and Analgesics
- 1st Edition - December 15, 2021
- Imprint: Academic Press
- Editors: Rajkumar Rajendram, Vinood Patel, Victor R Preedy
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 0 6 6 - 6
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 0 3 1 3 - 4
The Neuroscience of Pain, Anesthetics and Analgesics examines the syndromes of pain and how they interlink with anesthesia and analgesics. The book covers assessments, s… Read more
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The Neuroscience of Pain, Anesthetics and Analgesics examines the syndromes of pain and how they interlink with anesthesia and analgesics. The book covers assessments, screening and resources, and provides applications to related areas of medicine. It explores how the perception of pain results from a multifaceted interaction between illness beliefs, age, gender, time of onset, stress, socioeconomic status, and other factors. In addition, it scrutinizes how the neuroscience of pain in one condition may be relevant to understanding pain observed in other conditions. Sections address the onset of pain, the cause of pain, and the administration of analgesia or anesthesia.
The book works to clarify all of the subjects pertinent to anesthesia and the brain. Featuring chapters on neurotransmitters, pharmacology and brain imaging, this volume discusses the mechanisms of pain and experimental studies undertaken to better understand the pathways involved.
- Includes content on the features and assessments of pain, anesthesia and analgesia
- Provides a mini-dictionary of terms and summary points that succinctly encapsulate each chapter
- Covers a broad range of topics related to the neuroscience of analgesics and anesthetics
- Helps readers navigate key areas for research and further clinical recommendations
- Features chapters on molecular pathways, imaging and a deep look at behavior associated with the experience of pain
Neuroscientists, anesthesiologists, neurologists, clinicians, graduate students, and post-doctoral fellows. Neurologists, anesthesiologists, pharmacologists, physiologists, psychologists, doctors, health care workers and experts in behavior. Academic libraries that covers the neuroscience of pain, anesthetics and analgesics. Undergraduates, postgraduate, lecturers, academic professors, and graduate students and trainees in the basic sciences or clinical disciplines who have an interest in pain mechanisms, diagnosis and/or management
Features and Assessments of Pain, Anaesthesia and Analgesia:
I. Setting the scene: General aspects of anesthesia, analgesics and pain1. The concept of multimorphic cancer pain: a new approach from diagnosis to treatmentAntoine Lemaire2. Recent advances in the linkage of attachment and pain: a new reviewAlessandro Failo3. The management of pain in older peopleFelicity Claire Veal and Kelsey Kwong Pui Ng4. Anesthesia and body mass: epidural depth and beyondMehmet Canturk5. Anesthetics and analgesic activities of herbal medicine: Review of the possible mechanism of actionU G Chandrika6. Analgesia-first sedation and multimodal analgesia in the intensive care unitJohn Devlin and Paul Szumita7. The multidisciplinary Acute Pain Service: features and experiencesStefano Turi, Deni Francesco, Marilena Marmiere, Renato Meani and Luigi Beretta8. Monitoring anaesthesia: EEG and beyhondWangning ShangGuan
II. The syndromes of pain9. Cluster headache and pain: features and treatmentsRoemer Brandt and G M. Terwindt10. Migraine and pain: features and treatmentsAlfonso Gil-Martinez11. Complex regional pain syndromeChristopher R. Phillips, CDR, MC and United States Navy12. Phantom limb pain.Christopher R. Phillips, CDR, MC and United States Navy13. Painful diabetic neuropathy: The roles of microglia Idris Bin Long14. Maternal deprivation and nociceptiionIraci Lucena da Silva Torres15. Giving birth and painPelin Corman Dincer16. Abdominal Pain in GastroparesiAsad Jehangir17. Appendicitis and related abdominal painMarcos Prada-Arias Sr.18. Ovarian hormones, site-specific nociception and hypertensionLuiz GS Branco, Bruna Maitan Santos and Glauce Crivelaro do Nascimento19. Linking the heart and pain: physiological and psychophysiological mechanismsDmitry M. Davydov20. Chronic pain in military veteransA.M. Baria21. Nociception during surgeryMunetaka Hirose22. Breast cancer and nociceptionGabriela Trevisan and Amanda Spring de Almeida23. Postoperative pain after rhinoplasty and rhinologic surgeryAnthony P. Sclafani24. Pain response, neonates and venipunctureDr Hardeep Kaur25. Carpal tunnel syndrome and painCarlos Cruz-Montecinos26. Pain and HIVSara Pullen27. Pain mechanisms in computer and smartphone usersAlberto Marcos Heredia-Rizo, Pascal Madeleine and Grace PY Szeto
III. Interlinking anesthesia, analgesics and pain 28. Patients' and health professionals' positions regarding the use of analgesics in cancer casesEtienne Mullet29. Linking compression of myofascial trigger points and musculoskeletal painHisao Nishijo30. Multimodal analgesia and post-surgical painGiustino Varrassi, Martina Rekatsina, Antonella Paladini and Giorgia Saltelli31. Pain, ultrasound-guided Pecs II block and general anesthesiaA A Gde Putra Semara Jaya, Marilaeta Cindryani and Tjokorda Gde Agung Senapathi32. Pain control during prostate biopsy and evolution of local anesthesia techniqesMustafa Suat Bolat, Önder Cinar, Ali Batur, Ramazan Aşcı and Recep Büyükalpelli33. Pain reduction, in cosmetic injections: fillers and beyondRoya Sabzian, Hamid Reza Fallahi, Seied Omid Keyhan and Dana Zandian34. Anesthesia and combat-related extremity injuryRobert (Trey) Henry Burch III35. Spinal anesthesia: applications to cesarean section and painReyhan Arslantas36. Postoperative Pain Management: Truncal blocks in thoracic surgery Gulbin Tore Altun37. Postoperative Pain Management: Truncal blocks in general surgeryGulbin Tore Altun38. Linking analgesia, epidural oxycodone, pain and laparoscopyMerja Kokki and Hannu Kokki39. Levobupivacaine features and linking in infiltrating analgesiaDinko Bagatin, Tomica Bagatin, Johann Nemrava, Judith Adrianne Deutsch, Katarina Sakic, Livija Sakic, Maja Malic, Martina Ivelj, Josip Lovric and Zlatko Klanjcic
IV. Assessments, screening and resources40. The Pain Catastrophizing Scale: Features and ApplicationsTurgay Tuna41. The Pain Behaviour Scale (PaBS)Dalyah Alemam42. The analgesia nociception index: features and applicationSriganesh Kamath and Sonia Bansal43. Back Pain Evaluation QuestionnaireJun Komatsu44. The Back Pain Functional Scale: features and applicationsMeltem Koç45. Cognitive impairment, pain and analgesiaVanesa Cantón-Habas, José Manuel Martínez-Martos, Manuel Rich-Ruiz, Maria Jesus Ramirez-Exposito and María Pilar Carrera-González46. Biomarkers in endometriosis-associated painLuis Bahamondes and Deborah Margatho Sr.47. Biomarkers in bladder pain syndrome: a new narrativeThais Fontes de Magalhaes and Jorge Haddad48. Biomarkers of statin-induced musculoskeletal pain: Vitamin D and beyondMichele Malaguarnera49. Performance-based and self-reported physical fitness as a powerful marker of musculoskeletal painFernando Estevez-Lopez
Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics:
I. Drugs and agents used in anesthesia and analgesia1. Anesthesia for malignant hyperthermia susceptible patientsHelga Cristina Almeida da Silva, Calim Neder and Mariana Lima2. Use of dextran in regional anesthesiaMasahiko Tsuchiya3. Intraperitoneal local anesthetic agents in the management of post-operative painKarlin Sevensma4. Automatic control of anesthesia via different vital signsJiann-Shing Shieh, Jerry Chen and Maysam F. Abbod5. Non-opioid based analgesia in otolaryngologyKhanh K. Nguyen, Yohanan Kim and Anthony Sanchez
II. Mechanisms of action of drugs6. Buprenorphine: mechanisms and applicationsAnuj Aggarwal and Albert Lin7. Caffeine usage in pain managementThomas Weiser8. Chloroprocaine: features and applicationsAlain Borgeat9. Clonidine: features and applicationsRenato Gomez and Magda Lourenço Fernandes10. An excursion into secondary pharmacology of fentanyls with potential implications for drug design: σ1 receptorPiotr F. J. Lipiński11. Isoflurane: mechanisms and applicationsAlexander Bautista12. The lidocaine patch: features and applications: post-thoracotomy pain and beyondAlfonso Fiorelli13. Memantine: features and application to chronic pain control Harsha Shanthanna14. Midazolam: Perioperative administrationJoe C. Hong15. Intravenous paracetamol: features and applicationsRistiawan Muji Laksono16. Prilocaine: mechanisms and applicationsSreekantha Babu Jonnalagadda17. Sevoflurane: features and use in topical application for wound careManuel Gerónimo-Pardo18. Tramadol as an analgesicAyman M. Mahmoud
III. Adverse effects, reactions and outcomes19. Long-term effects of anaesthesia on the brain: an update on neurotoxicityRajkumar Rajendram20. Neuraxial labour analgesia and breast feedingRoberto Giorgio Maria F. Wetzl21. Mechanistic Overview of How Opioid Analgesics Promote ConstipationJesse Di Cello22. Cognitive-behavioral therapy for opioid use disorder and chronic painDeclan Barry23. Preoperative opioid and benzodiazepines: impact on adverse outcomes Martin Ingi Sigurdsson24. Anesthetics, Malignant hyperthermia syndrome and Kv7 channelsMariarosaria. Bucci, Valentina Vellecco, Antonio Mancini and Giuseppe Cirino25. Problems with epidural catheterMustafa Kemal Arslantas26. Headache after neuroaxial blocks: a focus on combined-epidural anesthesiaReyhan Arslantas27. Liposomal bupivacaine, pain relief and adverse eventsAlparslan Turan28. Adverse events associate with analgesics: a focus on paracetamol useGrzegorz Porebski and Iwona Popiolek
IV. Novel and non-pharmacological aspects and treatments29. Acronychia pedunculata leaves and usage in painU G Chandrika and W. M. K. M. Ratnayake30. Adansonia digitata and use in neuropathic pain: prostaglandins and beyondAboyeji Lukuman Oyewole, Abdulmusawwir Alli-Oluwafuyi, Abdulrazaq Nafiu and Aminu Imam31. Andrographis paniculata standardized extract (ParActin) and painRafael A. Burgos32. Capsaicin: features usage in diabetic neuropathic painKongkiat Kulkantrakorn33. Cola nitida and Pain reliefLawrence Dayo Adedayo34. Analgesic effects of Ephedra Herb extract and ephedrine alkaloids-free Ephedra Herb extract (EFE)Sumiko Hyuga, Shunsuke Nakamori, Yoshiaki Amakura, Masashi Hyuga, Nahoko Uchiyama, Yoshinori Kobayashi, Takashi Hakamatsuka, Yukihiro Goda, Hiroshi Odaguchi and Toshihiko Hanawa35. Euphorbia bicolor (Euphorbiaceae) Latex Phytochemicals and applications to analgesia Paramita Basu, Dayna Loyd Averitt and Camelia Maier Maier36. Pain relieving activity of muntingia calabura l.: elucidation of possible mechanisms of action and identification of responsible phytoconstituents Zainul Amiruddin Zakaria37. Resolving neuroinflammation and pain with Maresin 1, a specialized pro-resolving lipid mediatorWaldiceu A. Verri Jr., Victor Fattori, Camila Ferraz, Fernanda Soares Rasquel-Oliveira, Tiago H. Zaninelli, Sergio Marques Borghi and Rubia Casagrande38. Therapeutic role of naringenin to alleviate inflammatory painWaldiceu A. Verri Jr., marilia Fernandes manchope, Camila Ferraz, Sergio Marques Borghi, Fernanda Soares Rasquel-Oliveira, Anelise Franciosi, Julia Bagatim de Souza, Amanda Martins Dionisio and Rubia Casagrande39. Analgesic properties of Solanum paniculatum and S.torvum extractsFrancisco José Roma Paumgartten40. Dietary constituents contribute to local anesthetic agent: neurophysiologicals mechanism of nociceptive painMamoru Takeda41. Pain response following prenatal stress and its modulation by antioxidantsC B Abd Aziz42. Physical activity and fitness in the prevention of musculoskeletal pain in youthFernando Estevez-Lopez, Pablo Molina-García Sr. and Patrocinio Ariza-Vega43. Linking aerobic exercise and childhood pain alleviation: a narrativeC. Cushing44. Physical activity and exercise in the management of musculoskeletal pain: a focus on fibromyalgiaFernando Estevez-Lopez45. Spinal cord stimulation and limb pain Usman Latif and Timothy Sowder46. Effectiveness of neural mobilization on pain and disability in individuals with musculoskeletal disorders Carlos Romero Morales47. Virtual reality and applications to treating neck painM. Razeghi48. Virtual reality-induced analgesia and dental pain Elitsa Veneva49. Vibrotactile devices, DentalVibe and local anesthesiaElitsa Veneva, Ani Belcheva and Ralitsa D. Raycheva50. Cooled radiofrequency ablation (CRFA) and osteoarthritis treatment for painAntonia Chen and Eric Moorhead51. Non-pharmacologic analgesic therapies: a focus on photobiomodulation, acustimulation and cryoanalgesia (ice) therapyRoya Yumul, Ofelia Loani Elvir Lazo and Paul Frederick White52. New coping strategies and self-education for chronic pain management: e-healthVictoria Mazoteras Pardo, Marta San-Antolín, Daniel López-López, Ricardo Becerro-de-Bengoa-Vallejo, Marta Losa-Iglesias, Carlos Romero Morales, David Rodríguez-Sanz, Eva María Martinez-Jiménez and César Calvo-Lobo Sr.53. Postoperative Pain Management Truncal blocks in obstetric and gynecologic surgery Pelin Corman Dincer
The Neurobiology, Physiology and Psychology of Pain:
I. Molecular and cellular aspects1. Gene expression, KCNQ/Kv7 channels and neuropathic pain Q. Yang and Zizhen Wu2. The NTRK1 gene and congenital insensitivity to painMaryam Sobhani3. Prdm12, a key transcriptional regulator of the nociceptive lineageEric Joseph Bellefroid4. Linking the genetics of fibromyalgia and painFernando Estevez-Lopez5. Fentanyl: Polymorphisms, and adverse eventsAna M. Peiro6. Propofol anesthesia and molecular changes in the brainVesna Pesic7. Protein Kinase G is a Molecular Switch for PainY-J Sung8. Adrenergic agonists and the mu opioid receptor Robert Root-Bernstein9. Inflammatory and neuropathic pain impact on the opioid function in the mesocorticolimbic systemLHipolito, Yolanda Campos-Jurado, Javier Cuitavi Javier, Natalia Landsberg and Jesús David Lorente10. Clinacanthus nutans, analgesia and the l-arginine/nitric oxide-mediated/cyclic-guanosine monophosphate-independent pathwayZainul Amiruddin Zakaria11. alpha2/3-selective GABAA receptor PAMs as pain medications Jeffrey Witkin and Rok Cerne12. alpha5GABAA receptors and their role in pain perception Rodolfo Delgado-Lezama, Úrzula Franco-Enzástiga, Yarim De la Luz-Cuellar, Luis Eduardo Hernández-Reyes, Guadalupe Raya-Tafolla, Janet Murbartián, Vinicio Granados-Soto and Jorge Elías Torres-López13. ATP sensitive potassium channels in pain and analgesia Celina MC Lotufo, Tais Campos Lima and Débora Oliveira Santos14. Astrocyte-neuron lactate shuttle and painMasahiro Ohsawa and Keisuke Miyamoto15. Nociception and sweet solutions: applications to inflammatory pain KHawla Nuseir16. Interlinking Interleukin-33 (IL-33), neuroinflammation and neuropathic pain Camila Ferraz, Fernanda Soares Rasquel-Oliveira, Sergio Marques Borghi, Anelise Franciosi, Thacyana Carvalho, Telma Saraiva-Santos, Nayara Anitelli Artero, Rubia Casagrande and Waldiceu A. Verri Jr.17. Neurons of the parabrachial nucleus, nociceptive input and pain pathways Masashi Fujitani18. Anterior cingulate cortex, pain perception and pathological neuronal plasticity during chronic painFernando Kasanetz19. Sleep deprivation headaches and Fos immunohistochemistryJeongWook Park and Seonghoon Kim20. Antinociceptive glucagon-like peptidesDuygun Altıntaş Aykan21. Pain transmission and peripheral group III metabotropic glutamate receptors (mGluRs)Hee Chul Han and Eui Ho Park22. TRPM -8 receptor and menthol in pain managementMerja Kokki
II. Physiology, imaging and physical recordings 23. Anesthetic and proconvulsant effects of ketamine on EEG Shaila Gowda and Charles Akos Szabo24. Electroencephalography and anesthetic doses of ketamineJamie Sleigh25. Linking heart function and analgesiaGiustino Varrassi, Giorgia Saltelli, Antonella Paladini and Martina Rekatsina26. Computed Tomography-guided procedures for epidural injections Semih Gungor27. Chronic pain: Linking deep brain stimulation and sensory functional MRIWitold Henryk Polanski and Johann Klein28. Neurocognition and placebo analgesia: linking in functional magnetic resonance imaging Sara Palermo29. Linking the cortex, functional spectroscopy and pain: features and applicationsWolnei Caumo Sr.30. Muscle origins of myofascial pain syndromeEva María Martinez-Jiménez
III. Psychology and Behaviour31. Behavioral markers of painScott Holmes, Aisling E. Quinlan and Meghan Pierce32. Adverse life events, sensitization of spinal nociception, and chronic pain riskJamie Lynn Rhudy and Natalie Hellman33. Cognitive-affective modulation of pain: The Placebo and nocebo phenomena and their impact on pain treatmentSergiu Albu, Hans Linsenbardt and Mary Meagher34. Nociception-related behavioral phenotypes in adult zebrafishFabiano Vargas Costa Sr.35. Pain, implantable pain devices and psychosocial aspects as a narrativeK. Chakravarthy and Vishal Varshney36. Influence of psychological factors in myofascial painCésar Calvo-Lobo Sr.
IV. Resources37. ResourcesRajkumar Rajendram
- Edition: 1
- Published: December 15, 2021
- Imprint: Academic Press
- Language: English
RR
Rajkumar Rajendram
Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.
Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.
Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.
Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.
Affiliations and expertise
Consultant, Medical Protocol Department, King Abdulaziz Medical City, Ministry of National Guard Heath Affairs, Riyadh, Saudi ArabiaVP
Vinood Patel
Vinood B. Patel, BSc, PhD, FRSC, is currently Professor in Clinical Biochemistry at the University of Westminster. In 2014 Dr Patel was elected as a Fellow to The Royal Society of Chemistry. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School, NC, USA studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding mitochondrial oxidative stress in neurological disorders and iron dysregulation in diabetes. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to the use or investigation of active agents or components. These books include The Handbook of Nutrition, Diet, and Epigenetics, Branched Chain Amino Acids in Clinical Nutrition, Cancer: Oxidative Stress and Dietary Antioxidants, Toxicology: Oxidative Stress and Dietary Antioxidants, Molecular Nutrition: Vitamins, The Neuroscience of Pain, Cognitive Behavioural Therapy. He is Editor of the ten-volume series Biomarkers in Disease: Methods, Discoveries and Applications.
Affiliations and expertise
Professor, Clinical Biochemistry, School of Life Sciences University of Westminster, London, UKVP
Victor R Preedy
Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.
Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK Visiting Professor, University of Hull, UK