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The Mouse in Biomedical Research

Immunology

  • 2nd Edition, Volume 4 - December 5, 2006
  • Latest edition
  • Editors: James G. Fox, Stephen Barthold, Muriel Davisson, Christian E. Newcomer, Fred W. Quimby, Abigail Smith
  • Language: English

Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on t… Read more

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Description

Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.

Readership

Veterinary and medical students, graduate students, post-docs, immunologists, and researchers who utilize animals in biomedical research

Table of contents

Volume IV Immunology


1. The Molecular Basis of Lymphoid Architecture in the Mouse
Carola G. Vinuesa and Matthew C. Cook


2. The Biology of Toll-like Receptors in Mice
Osamu Takeuchi and Shizuo Akira


3. Genomic Organization of the Mouse Major Histocompatibility Complex
Attila Kumánovics


4. Some Biological Features of Dendritic Cells in the Mouse
Kang Liu, Anna Charalambous and Ralph M. Steinman


5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch
Recombination of Immunoglobulin Genes
Maria D. Iglesias-Ussel, Ziqiang Li, and Matthew D. Scharff


6. Mouse Natural Killer Cells: Function and Activation
Francesco Colucci


7. Cytokine-activated JAK-STAT Signaling in the Mouse Immune System
Bin Liu and Ke Shuai


8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse
Lakshmi R. Nagarajan and Yoji Shimizu


9. Mouse Models of Negative Selection
Troy A. Baldwin, Timothy K. Starr and Kristin A. Hogquist


10. Peripheral Tolerance of T Cells in the Mouse
Vigo Heissmeyer, Bogdan Tanasa, and Anjana Rao


11. The Genetics of Mouse Models of Systemic Lupus
Srividya Subramanian and Edward K. Wakeland


12. Inhibitory Receptors and Autoimmunity in the Mouse
Menna R. Clatworthy and Kenneth G.C. Smith


13. Mouse Models of Immunodeficiency
B. Anne Croy, James P. Di Santo, Marcus Manz, and Richard B. Bankert


14. Mouse Models to Study the Pathogenesis of Allergic Asthma
Chad E. Green, Nicholas J. Kenyon, Scott I. Simon, and Fu-Tong Liu


15. The Mouse Trap: How Well Do Mice Model Human Immunology?
Javier Mestas and Christopher C.W. Hughes

Product details

  • Edition: 2
  • Latest edition
  • Volume: 4
  • Published: December 5, 2006
  • Language: English

About the editors

JF

James G. Fox

Prof. James G. Fox obtained his Doctor of Veterinary Medicine at Colorado State University, Fort Collins, and, as an NIH postdoctoral fellow, received a Master of Science in Medical Microbiology at Stanford University. Dr. Fox is an adjunct professor at Tufts University School of Veterinary Medicine. He is a diplomate and a past president of the American College of Laboratory Animal Medicine, as well as a past president of the Massachusetts Society for Medical Research and the American Association of Veterinary Medical Colleges. Additionally, he has served as past chairman of the AAALAC Council and the NCCR/NIH Comparative Medicine Study Section. He is also an elected fellow of the Infectious Disease Society of America and the American Gastroenterological Association. He was recruited to MIT and created the Division of Comparative Medicine, which he directed from 1974 until 2021. As a faculty member in the MIT Department of Biological Engineering, Professor Fox received numerous scientific awards and was elected to the National Academy of Medicine in 2004. Dr. Fox has been the principal investigator of an NIH postdoctoral training grant for veterinarians for 30 years and has trained 90 veterinarians for careers in biomedical research. The NIH has continuously funded him to study infectious diseases of the gastrointestinal tract, where he has studied the gastrointestinal microbiome and how it interfaces with and influences the host’s immune response to gastrointestinal pathogens, particularly oncogenic Helicobacter species. He has authored over 600 papers, 84 chapters, holds 4 patents and has authored or edited 18 comparative medicine texts.

Affiliations and expertise
Division of Comparative Medicine, Department of Biological Engineering, MIT, Cambridge, MA, USA

SB

Stephen Barthold

Affiliations and expertise
Center for Comparative Medicine, UC Davis School of Veterinary Medicine, Davis CA

MD

Muriel Davisson

Affiliations and expertise
The Jackson Laboratory, Bar Harbor, Maine

CN

Christian E. Newcomer

Affiliations and expertise
Research Animal Resources and Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD

FQ

Fred W. Quimby

Affiliations and expertise
Laboratory Animal Research Center, The Rockefeller University, New York, NY

AS

Abigail Smith

Affiliations and expertise
School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA