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The Mouse in Biomedical Research
Normative Biology, Husbandry, and Models
- 2nd Edition, Volume 3 - November 30, 2006
- Editors: James G. Fox, Stephen Barthold, Muriel Davisson, Christian E. Newcomer, Fred W. Quimby, Abigail Smith
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 6 9 4 5 7 - 7
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 4 6 9 0 7 - 2
Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overvi… Read more
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Request a sales quoteNormative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse’s normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.
Veterinary and medical students, senior graduate, graduate students, post-docs, and researchers who utilize animals in biomedical research
- Cover image
- Title page
- Table of Contents
- Copyright
- List of Reviewers for Chapters in this Volume
- Contributors
- Foreword for Volume III
- Preface
- Normative Biology
- Chapter 1: Gross Anatomy
- INTRODUCTION
- ACKNOWLEDGMENT
- Chapter 2: Mouse Physiology
- I. CARDIOVASCULAR SYSTEM
- II. RESPIRATORY PHYSIOLOGY
- III. THE DIGESTIVE SYSTEM
- IV. METABOLISM: THE PROBLEM OF SIZE
- V. THERMOREGULATION
- VI. RENAL PHYSIOLOGY*
- VII. WATER REGULATION
- ACKNOWLEDGMENTS
- Chapter 3: Reproductive Biology of the Laboratory Mouse
- I. ONTOGENY OF THE REPRODUCTIVE SYSTEM
- II. ORGANIZATION AND FUNCTION OF THE REPRODUCTIVE TRACT
- III. MANAGING REPRODUCTION IN MICE
- ACKNOWLEDGMENTS
- Chapter 4: Endocrinology: Bone as a Target Tissue for Hormonal Regulation
- I. OVERVIEW
- II. BONE CELLULAR ORGANIZATION AND ACTIVITY
- III. HORMONAL ACTIONS ON BONE
- H. 1,25-Dihydroxy Vitamin D3 [1,25(OH)2D3]
- IV. SUMMARY
- Chapter 5: Hematology of the Laboratory Mouse
- I. INTRODUCTION
- II. GENERAL CONSIDERATIONS FOR MURINE HEMATOLOGY
- III. TECHNIQUES IN HEMATOLOGY
- IV. ERYTHROCYTES
- V. LEUKOCYTES
- VI. PLATELETS
- VII. HEMOSTASIS
- VIII. HEMATOLOGY OF THE MOUSE EMBRYO
- IX. HEMATOLOGY OF YOUNG MICE
- X. HEMATOLOGY OF AGING MICE
- XI. THE ROLE OF THE SPLEEN IN MURINE HEMATOPOIESIS
- XII. CONCLUSIONS
- ACKNOWLEDGMENTS
- Chapter 6: Clinical Chemistry of the Laboratory Mouse
- I. INTRODUCTION
- II. METHODS OF ANALYSIS AND INSTRUMENTATION
- III. SAMPLING
- IV. REFERENCE RANGES
- V. SPECIFIC TESTS
- Management, Techniques, and Husbandry
- Chapter 7: Gnotobiotics
- I. TERMINOLOGY
- II. HISTORICAL HIGHLIGHTS IN GNOTOBIOTICS
- III. ISOLATOR TECHNOLOGY
- IV. DERIVATION OF GNOTOBIOTIC MICE
- V. ASSOCIATING GERMFREE MICE WITH DEFINED FLORA
- VI. MONITORING FOR ISOLATOR CONTAMINATION
- VII. ASSOCIATION FOR GNOTOBIOTICS
- Chapter 8: Management and Design: Breeding Facilities
- I. INTRODUCTION
- II. FACILITIES FOR BREEDING MICE
- III. MICROBIOLOGIC STATUS
- IV. ESTABLISHING A BREEDING COLONY
- V. GENETIC QUALITY CONTROL
- Chapter 9: Design and Management of Research Facilities for Mice
- I. INTRODUCTION
- II. ARCHITECTURE AND ENGINEERING
- III. ENVIRONMENTAL CONTROL AND MONITORING
- IV. EQUIPMENT
- V. MATERIALS
- VI. OPERATIONAL ISSUES
- VII. ENVIRONMENTAL ENRICHMENT
- VIII. CONCLUSION
- Chapter 10: Nutrition
- I. INTRODUCTION
- II. NUTRIENTS: MEASUREMENT AND REQUIREMENTS
- III. CONTAMINANTS IN DIET
- IV. LABORATORY TESTING
- V. DIET TYPES AND FORMULAS
- VI. DIET MANUFACTURE
- VII. STORAGE OF DIET
- VIII. DECONTAMINATION OF DIET
- IX. DIET RESTRICTION
- X. INFLUENCE OF DIET ON INFECTIOUS DISEASES AND IMMUNITY
- XI. WATER
- XII. CONCLUDING COMMENTS
- Chapter 11: Health Delivery and Quality Assurance Programs for Mice
- I. INTRODUCTION
- II. HEALTH CARE PROVISION FOR EXPERIMENTAL MICE
- III. QUALITY ASSURANCE (QA) PROGRAMS FOR MICE
- IV. INFECTIOUS OUTBREAK SOURCES AND MANAGEMENT
- V. LIMITATIONS OF OUR CURRENT KNOWLEDGE AND FUTURE DIRECTIONS
- Chapter 12: Environmental and Equipment Monitoring
- I. INTRODUCTION
- II. MANAGEMENT
- III. ENVIRONMENTAL FACTORS
- IV. EQUIPMENT AND SYSTEMS
- V. FEED AND BEDDING
- VI. SANITATION
- VII. MONITORING FOR PESTS
- VIII. CONCLUSION
- Chapter 13: Biomethodology and Surgical Techniques
- I. INTRODUCTION
- II. HANDLING, IDENTIFICATION, AND RESTRAINT
- III. DRUG ADMINISTRATION
- IV. COLLECTION OF BIOLOGIC SPECIMENS
- V. ANESTHESIA
- VI. SURGICAL PROCEDURES
- VII. POSTANESTHETIC AND POSTOPERATIVE CARE
- VIII. EUTHANASIA
- IX. NECROPSY
- Chapter 14: In-Vivo Whole-Body Imaging of the Laboratory Mouse
- I. INTRODUCTION
- II. GENERAL FEATURES
- III. ADVANTAGES AND OPPORTUNITIES
- IV. DISADVANTAGES AND CHALLENGES
- V. LOGISTICAL ASPECTS
- VI. X-RAY IMAGING, INCLUDING X-RAY COMPUTED TOMOGRAPHY
- VII. ULTRASOUND
- VIII. MAGNETIC RESONANCE IMAGING
- IX. NUCLEAR IMAGING
- X. OPTICAL IMAGING
- XI. MULTIMODALITY IMAGING
- XII. SUMMARY
- ACKNOWLEDGMENTS
- Use of Mice in Biomedical Research
- Chapter 15: Behavioral Testing
- I. BEHAVIORAL PHENOTYPES
- II. APPROACHES TO MEASURING BEHAVIOR
- III. BEHAVIORAL DOMAINS AND SUBDOMAINS
- IV. MEASURING BEHAVIOR
- V. PLANNING BEHAVIORAL EXPERIMENTS
- VI. CONDUCTING A BEHAVIORAL TEST
- VII. SOURCES OF INFORMATION
- VIII. CONCLUSIONS AND RECOMMENDATIONS
- ACKNOWLEDGMENT
- Chapter 16: Cardiovascular Disease: Mouse Models of Atherosclerosis
- I. INTRODUCTION
- II. MOUSE MODELS OF ATHEROSCLEROSIS
- III. MODIFIERS OF ATHEROSCLEROSIS
- IV. INDUCTION OF CVD IN ATHEROSCLEROTIC MICE
- V. SUMMARY AND PERSPECTIVE
- Chapter 17: Convulsive Disorders
- I. INTRODUCTION
- II. HOMOLOGOUS MOUSE MODELS OF HUMAN EPILEPSY
- III. ORPHAN MOUSE MUTANTS
- IV. MULTIFACTORIAL EPILEPSY
- V. CONCLUSION
- ACKNOWLEDGMENTS
- Chapter 18: Eye Research
- I. INTRODUCTION
- II. RELEVANCE OF MICE IN EYE RESEARCH
- III. PHENOTYPIC EFFECTS PRODUCED BY STRAIN BACKGROUND AND STOCHASTIC EVENTS
- IV. OCULAR ANGIOGENESIS
- V. GLAUCOMA MODELS
- VI. MOLECULAR MECHANISMS IN RETINAL DEGENERATION
- Chapter 19: Genetic Analysis of Rodent Obesity and Diabetes
- I. THE OBESITY AND DIABETES CRISIS
- II. OBESITY IS INFLUENCED BY MANY GENES
- III. MOUSE MODELS OF OBESITY AND DIABETES USED IN GENETIC ANALYSIS
- IV. FUTURE DIRECTIONS
- Chapter 20: Mouse Models in Aging Research
- I. INTRODUCTION
- II. AGING, SENESCENCE, AND DISEASE: DEFINITIONS AND APPLICATION TO AGING RESEARCH
- III. BASICS OF EXPERIMENTAL DESIGN AND HUSBANDRY IN AGING RESEARCH
- IV. EXAMPLES OF GERONTOLOGIC STUDIES AND MOUSE MODELS USED
- V. SUMMARY AND CONCLUSIONS
- Chapter 21: Mouse Models of Inherited Human Neurodegenerative Disease
- I. INTRODUCTION
- II. INHERITED DEVELOPMENTAL DEGENERATIONS OF THE MOUSE
- III. MOUSE MODELS OF INHERITED HUMAN NEURODEGENERATION
- IV. CONCLUSIONS
- Chapter 22: Mouse Skin Ectodermal Organs
- I. INTRODUCTION
- II. HAIR FOLLICLES
- III. SEBACEOUS GLANDS
- IV. INTERFOLLICULAR SKIN
- V. SWEAT GLANDS
- VI. NAILS
- VII. VOLAR PADS
- VIII. MAMMARY GLANDS
- IX. CONCLUSION
- ACKNOWLEDGMENTS
- Chapter 23: Quality Control Testing of Biologics
- I. INTRODUCTION
- II. OVERVIEW OF MICROBIOLOGIC QUALITY CONTROL
- III. PRODUCTION
- IV. MICROBIOLOGIC QUALITY CONTROL TESTING
- V. NONMICROBIOLOGIC QUALITY CONTROL TESTING
- VI. INVESTIGATION OF OUT-OF-SPECIFICATION (OOS) RESULTS
- Index
- No. of pages: 816
- Language: English
- Edition: 2
- Volume: 3
- Published: November 30, 2006
- Imprint: Academic Press
- Hardback ISBN: 9780123694577
- eBook ISBN: 9780080469072
JF
James G. Fox
Prof. Fox obtained his Master of Science degree in Medical Microbiology at Stanford University and a Doctor in Veterinary Medicine at Colorado State University, Fort Collins. Dr. Fox is an Adjunct Professor at Tufts University School of Veterinary Medicine and the University of Pennsylvania, School of Veterinary Medicine. He is a Diplomate and a past president of the American College of Laboratory Animal Medicine, past president of the Massachusetts Society of Medical Research, past chairman of AAALAC Council, and past chairman of the NCCR/NIH Comparative Medicine Study Section. He also is an elected fellow of the Infectious Disease Society of America. In 2004 Professor Fox was elected to the Institute of Medicine of the National Academy of Sciences.
Affiliations and expertise
Division of Comparative Medicine, Department of Biological Engineering, MIT, Cambridge, MA, USASB
Stephen Barthold
Affiliations and expertise
Center for Comparative Medicine,
UC Davis School of Veterinary Medicine,
Davis CAMD
Muriel Davisson
Affiliations and expertise
The Jackson Laboratory,
Bar Harbor, MaineCN
Christian E. Newcomer
Affiliations and expertise
Research Animal Resources and Department of
Molecular and Comparative Pathobiology,
Johns Hopkins University,
Baltimore, MDFQ
Fred W. Quimby
Affiliations and expertise
Laboratory Animal Research Center,
The Rockefeller University,
New York, NYAS
Abigail Smith
Affiliations and expertise
School of Veterinary Medicine,
University of Pennsylvania
Philadelphia, PA