The Mouse in Biomedical Research
- 2nd Edition - December 1, 2006
- Latest edition
- Editors: James G. Fox, Stephen Barthold, Muriel Davisson, Christian E. Newcomer, Fred W. Quimby, Abigail Smith
- Language: English
In no other species of animal has such a wealth of experimental data been utilized for scientific pursuits. Now in its Second Edition, this Four Volume Set is dedicated to the… Read more
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Description
Description
In no other species of animal has such a wealth of experimental data been utilized for scientific pursuits. Now in its Second Edition, this Four Volume Set is dedicated to the understanding of the mouse and its role in scientific research. This valuable compendium serves as a standard reference source of information for students embarking on scientific careers, specialists in laboratory animal science, technicians in both animal care and research, and the broad scientific community. This set is also sold individually and covers History, Wild Mice, and Genetics; Diseases; Normative Biology, Husbandry, and Models; and Immunology.Volume 1: History, Wild Mice, and GeneticsKEY FEATURES:• A primer for scientists new to the field of mouse research• Information about the history, biology and genomics of the laboratory mouse (Mus musculus)• Mouse origins and relationships covered in chapters on history, evolutionary taxonomy and wild mice• Mouse genetics and genomics discussed in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome• Use of the mouse as a model system for basic biomedical research described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulationVolume 2: DiseasesKEY FEATURES:• New format by discussing specific disease causing microorganisms versus the format used in the first edition which discussed infectious diseases affecting specific organs and tissues• Consists of 26 chapters subdivided into RNA viruses and DNA viruses, mycotic, and parasitic infections. • Provides updates on pathogenesis, epidemiology and prevention of previously recognized murine pathogens• Offers information on newly recognized disease-causing organisms: mouse parvovirus, cilia associated respiratory bacilli and Helicobacter Volume 3: Normative Biology, Husbandry, and ModelsKEY FEATURES:• Encompasses 23 chapters with a broad overview on the laboratory mouse’s normative biology, husbandry, and its use as a model in biomedical research. • Includes chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry.• Discusses management, nutrition, gnotobiotics and disease surveillance• Provides analysis of the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases Volume 4: ImmunologyKEY FEATURES:• A complete new addition to this series, dedicated to mouse immunology including both the innate and adaptive immune systems• Based on the mouse as a choice model when studying immunity in man-arguably more is known about the immune system in mice than any other species except man• Chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells
Key features
Key features
NEW TO THIS EDITION:
* Over 50% new material
* Each volume contains 4-color page inserts with indispensable figures
* Greatly expanded sections on genetics including: the mouse genome, gene mapping, and gene therapy
* Information on newly recognized disease-causing organisms, such as mouse parvovirus and Helicobacter
* A volume entirely devoted to mouse immunology
* New section on stem cell biology
* Each of the four volumes are available individually
* Over 50% new material
* Each volume contains 4-color page inserts with indispensable figures
* Greatly expanded sections on genetics including: the mouse genome, gene mapping, and gene therapy
* Information on newly recognized disease-causing organisms, such as mouse parvovirus and Helicobacter
* A volume entirely devoted to mouse immunology
* New section on stem cell biology
* Each of the four volumes are available individually
Readership
Readership
Veterinary and medical students, senior graduate, graduate students, post-docs, and researchers who utilize animals in biomedical research
Table of contents
Table of contents
Volume I History, Wild Mice, and Genetics
1. Building a Better Mouse: One Hundred Years of Genetics and Biology
Herbert C. Morse III
2. Systematics of the genus Mus
Priscilla K. Tucker
3. The Secret World of Wild Mice
Grant R. Singleton and Charles J. Krebs
4. Breeding Systems: Considerations, Genetic Fundamentals, Genetic Background, and Strain Types
Melissa L. Berry and Carol Cutler Linder
5. Mouse Strain and Genetic Nomenclature: an Abbreviated Guide
Janan T. Eppig
6. The Mouse Genome
Mark D. Adams
7. Gene Mapping
Muriel T. Davisson
8. Genetic Monitoring
Richard R. Fox, Michael V. Wiles, and Petko M. Petkov
9. Cytogenetics
Muriel T. Davisson and Mary Ann Handel
10. Mouse Embryology: Research Techniques and a Comparison of Embryonic Development between Mouse and Man
M.H. Kaufman
11. Gamete and Embryo Manipulation
K.C. Kent Lloyd
12. Chemical Mutagenesis in Mice
Martin Hrabé de Angelis, Dian Michel, Sibylle Wagner, Sonja Becker and Johannes Beckers
13. Gene-Specific Mutagenesis
K.C. Kent Lloyd
14. Gene Transfer Studies Using Mouse Models
Robert G. Pergolizzi and Ronald G. Crystal
15. Mouse and Human Pluripotent Stem Cells
Leslie F. Lock
16. Drugs and the Mouse: Pharmacology, Pharmacogenetics, and Pharmacogenomics
Lucia F. Jorge-Nebert, Sandrine Derkenne and Daniel W. Nebert
Volume II Diseases
Viral Diseases
DNA Viruses
1. Mouse Cytomegalovirus and other Herpesviruses
Geoffrey R. Shellam, Alec J. Redwood, Lee M. Smith and Shelley Gorman
2. Mouse Adenoviruses
Katherine R. Spindler, Martin L. Moore, Angela N. Cauthen
3. Mousepox
R. Mark L. Buller and Frank Fenner
4. Parvoviruses
Robert O. Jacoby and Lisa Ball-Goodrich
5. Polyoma Viruses
Thomas L. Benjamin
RNA Viruses
6. Mouse Hepatitis Virus
Stephen W. Barthold and Abigail L. Smith
7. Lymphocytic Choriomeningitis Virus
Stephen W. Barthold and Abigail L. Smith
8. Lactate Dehydrogenase-Elevating Virus
Jean-Paul Coutelier and Margo A. Brinton
9. Reoviridae
Richard L. Ward, Monica M. McNeal, Mary B. Faron and Anthony L. Farone
10. Retroelements in the Mouse
Herbert C. Morse III
11. Sendai Virus and Pneumonia Virus of Mice (PVM)
David G. Brownstein
12. Cardioviruses: Encephalomyocarditis Virus and Theiler's Mouse Encephalomyelitis Virus
Howard L. Lipton, A.S. Manoj Kumar, and Shannon Hertzler
Bacterial Diseases
13. Chlamydial Diseases
Robert G. Rank
14. Clostridial Species
Kimberly S. Waggie
15. Enterobacteriaceae, Pseudomonas aeruginosa, and Streptobacillus moniliformis
Hilda Holcombe and David B. Schauer
16. Aerobic Gram-positive Organisms
Cynthia Besch-Williford and Craig L. Franklin
17. Helicobacter Infections in Mice
James G. Fox and Mark T. Whary
18. Mycoplasma pulmonis, Other Mouse Mycoplasmas, and Cilia-Associated Respiratory Bacillus
Trenton R. Schoeb
19. Pasteurellaceae
Werner Nicklas
Mycotic and Parasitic Diseases
20. Fungal Diseases in Laboratory Mice
Virginia L. Godfrey
21. Protozoa
Katherine Wasson
22. Helminth Parasites of Laboratory Mice
Kathleen R. Pritchett
23. Anthropods
David G. Baker
Miscellaneous Diseases
24. The Tumor Pathology of Genetically Engineered Mice: A New Approach to Molecular Pathology
Robert D. Cardiff, Robert J. Munn, and Jose J. Galvez
25. Spontaneous Diseases in Commonly Used Mouse Strains
Cory Brayton
26. Zoonoses and Other Human Health Hazards
Christian E. Newcomer and James G. Fox
Volume III Normative Biology, Husbandry, and Models
Normative Biology
1. Gross Anatomy
Vladimír Komárek
2. Mouse Physiology
Robert F. Hoyt, Jr., James V. Hawkins, Mark B. St Claire and Mary B. Kennett
3. Reproductive Biology of the Laboratory Mouse
Kate Pritchett and Robert Taft
4. Endocrinology: Bone as a target tissue for hormonal regulation
Krista M. Delahunty and Wesley G. Beamer
5. Hematology of the Laboratory Mouse
Nancy E. Everds
6. Clinical Chemistry of the Laboratory Mouse
Fred W. Quimby and Richard H. Luong
Management, Techniques, and Husbandry
7. Gnotobiotics
Richard J. Rahija
8. Management and Design: Breeding Facilities
William J. White
9. Design and Management of Research Facilities for Mice
Neil S. Lipman
10. Nutrition
Graham Tobin, Karla A. Stevens and Robert J. Russell
11. Health Delivery and Quality Assurance Programs for Mice
Diane J. Gaertner, Glen Otto and Margaret Batchelder
12. Environmental and Equipment Monitoring
J. David Small and Rick Deitrich
13. Biomethodology and Surgical Techniques
Alison M. Hayward, Laura B. Lemke, Erin C. Bridgeford, Elizabeth J. Theve, Courtnye N. Jackson, Terrie L. Cunliffe-Beamer, Robert P. Marini
14. In Vivo Whole-Body Imaging of the Laboratory Mouse
Simon R. Cherry
Use of Mice in Biomedical Research
15. Behavioral Testing
Douglas Wahlsten and John C. Crabbe
16. Cardiovascular Disease: Mouse Models of Atherosclerosis
Nobuyo Maeda, Raymond C. Givens and Robert L. Reddick
17. Convulsive Disorders
Mariana T. Todorova and Thomas N. Seyfried
18. Eye Research
Richard S. Smith, Patsy M. Nishina, John P. Sundberg, Johann Zwaan, and Simon W.M. John
19. Genetic Analysis of Rodent Obesity and Diabetes
Sally Chiu, Janis S. Fisler, and Craig H. Warden
20. Mouse Models in Aging Research
Kevin Flurkey, Joanne M. Currer, and D.E. Harrison
21. Mouse Models of Inherited Human Neurodegenerative Disease
Karl Herrup
22. Mouse Skin Ectodermal Organs
Maksim V. Plikus, John P. Sundberg, and Cheng-Ming Chuong
23. Quality Control Testing of Biologicals
William R. Shek
Volume IV Immunology
Molecular and Cellular Immunology of the Mouse: An Overview
Fred W. Quimby and David D. Chaplin
1. The Molecular Basis of Lymphoid Architecture in the Mouse
Carola G. Vinuesa and Matthew C. Cook
2. The Biology of Toll-like Receptors in Mice
Osamu Takeuchi and Shizuo Akira
3. Genomic Organization of the Mouse Major Histocompatibility Complex
Attila Kumánovics
4. Some Biological Features of Dendritic Cells in the Mouse
Kang Liu, Anna Charalambous and Ralph M. Steinman
5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch
Recombination of Immunoglobulin Genes
Maria D. Iglesias-Ussel, Ziqiang Li, and Matthew D. Scharff
6. Mouse Natural Killer Cells: Function and Activation
Francesco Colucci
7. Cytokine-activated JAK-STAT Signaling in the Mouse Immune System
Bin Liu and Ke Shuai
8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse
Lakshmi R. Nagarajan and Yoji Shimizu
9. Mouse Models of Negative Selection
Troy A. Baldwin, Timothy K. Starr and Kristin A. Hogquist
10. Peripheral Tolerance of T Cells in the Mouse
Vigo Heissmeyer, Bogdan Tanasa, and Anjana Rao
11. The Genetics of Mouse Models of Systemic Lupus
Srividya Subramanian and Edward K. Wakeland
12. Inhibitory Receptors and Autoimmunity in the Mouse
Menna R. Clatworthy and Kenneth G.C. Smith
13. Mouse Models of Immunodeficiency
B. Anne Croy, James P. Di Santo, Marcus Manz, and Richard B. Bankert
14. Mouse Models to Study the Pathogenesis of Allergic Asthma
Chad E. Green, Nicholas J. Kenyon, Scott I. Simon, and Fu-Tong Liu
15. The Mouse Trap: How Well Do Mice Model Human Immunology?
Javier Mestas and Christopher C.W. Hughes
1. Building a Better Mouse: One Hundred Years of Genetics and Biology
Herbert C. Morse III
2. Systematics of the genus Mus
Priscilla K. Tucker
3. The Secret World of Wild Mice
Grant R. Singleton and Charles J. Krebs
4. Breeding Systems: Considerations, Genetic Fundamentals, Genetic Background, and Strain Types
Melissa L. Berry and Carol Cutler Linder
5. Mouse Strain and Genetic Nomenclature: an Abbreviated Guide
Janan T. Eppig
6. The Mouse Genome
Mark D. Adams
7. Gene Mapping
Muriel T. Davisson
8. Genetic Monitoring
Richard R. Fox, Michael V. Wiles, and Petko M. Petkov
9. Cytogenetics
Muriel T. Davisson and Mary Ann Handel
10. Mouse Embryology: Research Techniques and a Comparison of Embryonic Development between Mouse and Man
M.H. Kaufman
11. Gamete and Embryo Manipulation
K.C. Kent Lloyd
12. Chemical Mutagenesis in Mice
Martin Hrabé de Angelis, Dian Michel, Sibylle Wagner, Sonja Becker and Johannes Beckers
13. Gene-Specific Mutagenesis
K.C. Kent Lloyd
14. Gene Transfer Studies Using Mouse Models
Robert G. Pergolizzi and Ronald G. Crystal
15. Mouse and Human Pluripotent Stem Cells
Leslie F. Lock
16. Drugs and the Mouse: Pharmacology, Pharmacogenetics, and Pharmacogenomics
Lucia F. Jorge-Nebert, Sandrine Derkenne and Daniel W. Nebert
Volume II Diseases
Viral Diseases
DNA Viruses
1. Mouse Cytomegalovirus and other Herpesviruses
Geoffrey R. Shellam, Alec J. Redwood, Lee M. Smith and Shelley Gorman
2. Mouse Adenoviruses
Katherine R. Spindler, Martin L. Moore, Angela N. Cauthen
3. Mousepox
R. Mark L. Buller and Frank Fenner
4. Parvoviruses
Robert O. Jacoby and Lisa Ball-Goodrich
5. Polyoma Viruses
Thomas L. Benjamin
RNA Viruses
6. Mouse Hepatitis Virus
Stephen W. Barthold and Abigail L. Smith
7. Lymphocytic Choriomeningitis Virus
Stephen W. Barthold and Abigail L. Smith
8. Lactate Dehydrogenase-Elevating Virus
Jean-Paul Coutelier and Margo A. Brinton
9. Reoviridae
Richard L. Ward, Monica M. McNeal, Mary B. Faron and Anthony L. Farone
10. Retroelements in the Mouse
Herbert C. Morse III
11. Sendai Virus and Pneumonia Virus of Mice (PVM)
David G. Brownstein
12. Cardioviruses: Encephalomyocarditis Virus and Theiler's Mouse Encephalomyelitis Virus
Howard L. Lipton, A.S. Manoj Kumar, and Shannon Hertzler
Bacterial Diseases
13. Chlamydial Diseases
Robert G. Rank
14. Clostridial Species
Kimberly S. Waggie
15. Enterobacteriaceae, Pseudomonas aeruginosa, and Streptobacillus moniliformis
Hilda Holcombe and David B. Schauer
16. Aerobic Gram-positive Organisms
Cynthia Besch-Williford and Craig L. Franklin
17. Helicobacter Infections in Mice
James G. Fox and Mark T. Whary
18. Mycoplasma pulmonis, Other Mouse Mycoplasmas, and Cilia-Associated Respiratory Bacillus
Trenton R. Schoeb
19. Pasteurellaceae
Werner Nicklas
Mycotic and Parasitic Diseases
20. Fungal Diseases in Laboratory Mice
Virginia L. Godfrey
21. Protozoa
Katherine Wasson
22. Helminth Parasites of Laboratory Mice
Kathleen R. Pritchett
23. Anthropods
David G. Baker
Miscellaneous Diseases
24. The Tumor Pathology of Genetically Engineered Mice: A New Approach to Molecular Pathology
Robert D. Cardiff, Robert J. Munn, and Jose J. Galvez
25. Spontaneous Diseases in Commonly Used Mouse Strains
Cory Brayton
26. Zoonoses and Other Human Health Hazards
Christian E. Newcomer and James G. Fox
Volume III Normative Biology, Husbandry, and Models
Normative Biology
1. Gross Anatomy
Vladimír Komárek
2. Mouse Physiology
Robert F. Hoyt, Jr., James V. Hawkins, Mark B. St Claire and Mary B. Kennett
3. Reproductive Biology of the Laboratory Mouse
Kate Pritchett and Robert Taft
4. Endocrinology: Bone as a target tissue for hormonal regulation
Krista M. Delahunty and Wesley G. Beamer
5. Hematology of the Laboratory Mouse
Nancy E. Everds
6. Clinical Chemistry of the Laboratory Mouse
Fred W. Quimby and Richard H. Luong
Management, Techniques, and Husbandry
7. Gnotobiotics
Richard J. Rahija
8. Management and Design: Breeding Facilities
William J. White
9. Design and Management of Research Facilities for Mice
Neil S. Lipman
10. Nutrition
Graham Tobin, Karla A. Stevens and Robert J. Russell
11. Health Delivery and Quality Assurance Programs for Mice
Diane J. Gaertner, Glen Otto and Margaret Batchelder
12. Environmental and Equipment Monitoring
J. David Small and Rick Deitrich
13. Biomethodology and Surgical Techniques
Alison M. Hayward, Laura B. Lemke, Erin C. Bridgeford, Elizabeth J. Theve, Courtnye N. Jackson, Terrie L. Cunliffe-Beamer, Robert P. Marini
14. In Vivo Whole-Body Imaging of the Laboratory Mouse
Simon R. Cherry
Use of Mice in Biomedical Research
15. Behavioral Testing
Douglas Wahlsten and John C. Crabbe
16. Cardiovascular Disease: Mouse Models of Atherosclerosis
Nobuyo Maeda, Raymond C. Givens and Robert L. Reddick
17. Convulsive Disorders
Mariana T. Todorova and Thomas N. Seyfried
18. Eye Research
Richard S. Smith, Patsy M. Nishina, John P. Sundberg, Johann Zwaan, and Simon W.M. John
19. Genetic Analysis of Rodent Obesity and Diabetes
Sally Chiu, Janis S. Fisler, and Craig H. Warden
20. Mouse Models in Aging Research
Kevin Flurkey, Joanne M. Currer, and D.E. Harrison
21. Mouse Models of Inherited Human Neurodegenerative Disease
Karl Herrup
22. Mouse Skin Ectodermal Organs
Maksim V. Plikus, John P. Sundberg, and Cheng-Ming Chuong
23. Quality Control Testing of Biologicals
William R. Shek
Volume IV Immunology
Molecular and Cellular Immunology of the Mouse: An Overview
Fred W. Quimby and David D. Chaplin
1. The Molecular Basis of Lymphoid Architecture in the Mouse
Carola G. Vinuesa and Matthew C. Cook
2. The Biology of Toll-like Receptors in Mice
Osamu Takeuchi and Shizuo Akira
3. Genomic Organization of the Mouse Major Histocompatibility Complex
Attila Kumánovics
4. Some Biological Features of Dendritic Cells in the Mouse
Kang Liu, Anna Charalambous and Ralph M. Steinman
5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch
Recombination of Immunoglobulin Genes
Maria D. Iglesias-Ussel, Ziqiang Li, and Matthew D. Scharff
6. Mouse Natural Killer Cells: Function and Activation
Francesco Colucci
7. Cytokine-activated JAK-STAT Signaling in the Mouse Immune System
Bin Liu and Ke Shuai
8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse
Lakshmi R. Nagarajan and Yoji Shimizu
9. Mouse Models of Negative Selection
Troy A. Baldwin, Timothy K. Starr and Kristin A. Hogquist
10. Peripheral Tolerance of T Cells in the Mouse
Vigo Heissmeyer, Bogdan Tanasa, and Anjana Rao
11. The Genetics of Mouse Models of Systemic Lupus
Srividya Subramanian and Edward K. Wakeland
12. Inhibitory Receptors and Autoimmunity in the Mouse
Menna R. Clatworthy and Kenneth G.C. Smith
13. Mouse Models of Immunodeficiency
B. Anne Croy, James P. Di Santo, Marcus Manz, and Richard B. Bankert
14. Mouse Models to Study the Pathogenesis of Allergic Asthma
Chad E. Green, Nicholas J. Kenyon, Scott I. Simon, and Fu-Tong Liu
15. The Mouse Trap: How Well Do Mice Model Human Immunology?
Javier Mestas and Christopher C.W. Hughes
Product details
Product details
- Edition: 2
- Latest edition
- Published: December 1, 2006
- Language: English
About the editors
About the editors
JF
James G. Fox
Prof. James G. Fox obtained his Doctor of Veterinary Medicine at Colorado State University, Fort Collins, and, as an NIH postdoctoral fellow, received a Master of Science in Medical Microbiology at Stanford University. Dr. Fox is an adjunct professor at Tufts University School of Veterinary Medicine. He is a diplomate and a past president of the American College of Laboratory Animal Medicine, as well as a past president of the Massachusetts Society for Medical Research and the American Association of Veterinary Medical Colleges. Additionally, he has served as past chairman of the AAALAC Council and the NCCR/NIH Comparative Medicine Study Section. He is also an elected fellow of the Infectious Disease Society of America and the American Gastroenterological Association. He was recruited to MIT and created the Division of Comparative Medicine, which he directed from 1974 until 2021. As a faculty member in the MIT Department of Biological Engineering, Professor Fox received numerous scientific awards and was elected to the National Academy of Medicine in 2004. Dr. Fox has been the principal investigator of an NIH postdoctoral training grant for veterinarians for 30 years and has trained 90 veterinarians for careers in biomedical research. The NIH has continuously funded him to study infectious diseases of the gastrointestinal tract, where he has studied the gastrointestinal microbiome and how it interfaces with and influences the host’s immune response to gastrointestinal pathogens, particularly oncogenic Helicobacter species. He has authored over 600 papers, 84 chapters, holds 4 patents and has authored or edited 18 comparative medicine texts.
Affiliations and expertise
Division of Comparative Medicine, Department of Biological Engineering, MIT, Cambridge, MA, USASB
Stephen Barthold
Affiliations and expertise
Center for Comparative Medicine,
UC Davis School of Veterinary Medicine,
Davis CAMD
Muriel Davisson
Affiliations and expertise
The Jackson Laboratory,
Bar Harbor, MaineCN
Christian E. Newcomer
Affiliations and expertise
Research Animal Resources and Department of
Molecular and Comparative Pathobiology,
Johns Hopkins University,
Baltimore, MDFQ
Fred W. Quimby
Affiliations and expertise
Laboratory Animal Research Center,
The Rockefeller University,
New York, NYAS
Abigail Smith
Affiliations and expertise
School of Veterinary Medicine,
University of Pennsylvania
Philadelphia, PAView book on ScienceDirect
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