
The Molecular Basis of Drug Addiction
- 1st Edition, Volume 137 - January 12, 2016
- Imprint: Academic Press
- Author: Shafiqur Rahman
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 0 3 7 8 6 - 7
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 3 8 6 8 - 0
This volume of Progress in Molecular Biology and Translational Science focuses on the molecular basis of drug addict… Read more

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- Informs and updates on all the latest developments in the field
Chapter One: Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects
- Abstract
- Abbreviations
- 1. Introduction
- 2. ERK Signaling Pathway
- 3. ERK Signaling and Drug Addiction
- 4. Conclusions and Future Directions
- Acknowledgment
Chapter Two: Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings
- Abstract
- 1. Alcoholism and Genetics
- 2. Central Glutamatergic Activity
- 3. Central Glutamate Activity and Alcohol Dependence
- 4. Glutamate-Associated Genetic Variations and Alcoholism
- 5. Alcohol and Glutamate Gene Expression
- 6. Alcohol-Associated Changes in Gene/Protein Expression of P Rats
- 7. Conclusions
- Acknowledgments
Chapter Three: S-Glutathionylation and Redox Protein Signaling in Drug Addiction
- Abstract
- 1. Introduction
- 2. Oxidative Stress
- 3. S-Glutathionylation of Proteins Occurs in Response to Oxidative Stress
- 4. S-Glutathionylation of Proteins is a Redox-Sensitive Signaling Mechanism in Cells
- 5. S-Glutathionylation in Addiction-Related Protein Signaling
- 6. S-Glutathionylation of PKA, PKC, Cdk5, and Actin May Influence Drug Behavior
- 7. S-Glutathionylation in Alcohol Addiction
- 8. S-Glutathionylation in Cocaine Addiction
- 9. S-Glutathionylation in Heroin Addiction
- 10. Future Research
- 11. Conclusions
- Acknowledgment
Chapter Four: Molecular Mechanisms of Cannabis Signaling in the Brain
- Abstract
- 1. Introduction
- 2. Chemical Components of Cannabis
- 3. Endocannabinoid System
- 4. Signal Transduction
- 5. CB1 Distribution
- 6. CB2 Receptors
- 7. Cannabis and Addiction
- 8. Animal Models
- 9. Molecular Adaptations to Chronic Use
- 10. Synaptic Plasticity
- 11. Cannabis Withdrawal
- 12. Monoaminergic Systems
- 13. Cannabidiol
- 14. The Case of Charlotte's Web
- 15. Conclusions
Chapter Five: The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction
- Abstract
- 1. Introduction
- 2. Orphanin FQ/Nociceptin/NOPr System
- 3. Molecular Mechanisms of Cocaine Addiction
- 4. Conclusions
Chapter Six: Recent Advances in Nicotinic Receptor Signaling in Alcohol Abuse and Alcoholism
- Abstract
- 1. Introduction
- 2. Mesolimbic-Dopamine System and nAChRs
- 3. Knockout and Transgenic Models and nAChRs
- 4. Alcohol, Nicotine Coabuse, and nAChRs
- 5. Genetic Polymorphisms, Alcohol Dependence and nAChRs
- 6. Alcohol Dependence, Comorbid Psychiatric Condition and nAChRs
- 7. Alcohol, Transcription Factors, and nAChRs
- 8. Conclusions
- Acknowledgments
Chapter Seven: Molecular Changes in Opioid Addiction: The Role of Adenylyl Cyclase and cAMP/PKA System
- Abstract
- 1. Introduction
- 2. The Adenylyl Cyclase Pathway
- 3. Opioid Effect on cAMP-Responsive Element-Binding Protein (CREB)
- 4. Molecular Changes in Brain Regions That May Underlie Opiate Dependence
- 5. Molecular Changes in the Ventral Tegmental Area
- 6. Molecular Changes in Other CNS Regions
- 7. Conclusions
Chapter Eight: Caenorhabditis elegans as a Model to Study the Molecular and Genetic Mechanisms of Drug Addiction
- Abstract
- 1. Introduction
- 2. Models of Addiction
- 3. Invertebrate Models
- 4. C. elegans as a Model System to Study Addiction
- 5. Drugs of Abuse
- 6. Convergent Mechanisms of Drugs of Abuse in C. elegans
- 7. Leveraging C. elegans for Model Development and Drug Discovery
- 8. Conclusions
- Acknowledgment
- Edition: 1
- Volume: 137
- Published: January 12, 2016
- Imprint: Academic Press
- No. of pages: 277
- Language: English
- Hardback ISBN: 9780128037867
- eBook ISBN: 9780128038680
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