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The molecular aspects of autoimmunity
1st Edition - February 28, 1990
Editor: Nadir Farid
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 5 6 2 3 - 3
The Molecular Aspects of Autoimmunity contains a selection of the papers presented at the first of a series of biannual meetings on molecular aspects of autoimmunity held in… Read more
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The Molecular Aspects of Autoimmunity contains a selection of the papers presented at the first of a series of biannual meetings on molecular aspects of autoimmunity held in L'Esterel, Quebec, Canada, October 30-November 2, 1988. The book contains 20 chapters and begins with a study of the expression of the Ly-1 gene and V gene families in autoantibodies. This is followed by separate chapters on the structural characteristics of human IgM autoantibodies; human IgV gene segments for autoantibodies; and the genetic basis of anti-DNA immune responses. Subsequent chapters cover topics such as the epibodies from the immune response to the acetylcholine receptor (AChR); the specificities and idiotypes of anti-histone H1 autoantibodies; T cell tolerance; and T cell antigen receptor (TCR) gene biology and the genomic composition and expressed repertoire of these genes in several autoimmune and normal mouse strains. Also discussed are MHC Class II associations with autoimmune disorders such as type 1 diabetes, rheumatoid arthritis, and thyroid disease.
Contributors
Preface
The Expression of LY-1 and Immunoglobulin Variable Gene Families in Hybridomas Producing Autoantibodies of Various Specificities
Structural Characteristics of Human IgM Autoantibodies
Molecular Genetics of Human Autoantibodies
Molecular Characterization of Human Anti-DNA Antibodies
From Idiotypic Expression of Lupus Anti-DNA Antibodies to Diversification of Ig Variable Region Genes
Murine Autoantibodies Specific for Bromelinized Red Blood Cells Use Restricted Set of Genetic Elements and Their Heavy Chains Define a Novel VH Family
Molecular Analysis of Murine Lupus-Associated Humoral Anti-Self Response
Establishment of V-Gene Repertoires in Normal Mice
Characterization of a Regulatory Idiotope by Antibody Engineering
Epibodies in the Immune Response to the Acetylcholine Receptor
Interspecies Idiotypes on Anti-Sm Antibodies
Specificities and Idiotypy of Anti-Histone HI Autoantibodies
Experimental Models of T Cell Tolerance
Genomic and Expressed T Cell Antigen Receptor Repertoire in Autoimmune Murine Models
Structure of the Human Interleukin 2 Receptor and the Biochemical Basis for Its Regulation
Viruses as a Triggering Factor of Autoimmune Type I Diabetes
Mapping Susceptibility to Rheumatoid Arthritis into a Conformationally Equivalent Region of MHC Class II Molecules Encoded by Different Alleles
In Vitro Model Systems for the Study of Thyroid Autoimmunity: Regulation of Rat MHC Class II Antigens
The Molecular Basis of MHC Association with Disease
Basic Role for Anti-Idiotype Autoantibodies in the Prevention of Experimental Autoimmune Thyroiditis
Index
- No. of pages: 318
- Language: English
- Published: February 28, 1990
- Imprint: Academic Press
- eBook ISBN: 9780323156233