Section I. The mitochondrion and gametes
Chapter 1
The role of the mitochondrion in sperm function. Is there a place for oxidative phosphorylation or is this a purely glycolytic process?
Eduardo Ruiz-Pesini, Carmen Díez-Sánchez, Manuel José López-Pérez and José Antonio Enríquez
Chapter 2
The role of mitochondrial function in the oocyte and embryo
Remi Dumollard, Michael Duchen, John Carroll
Chapter 3
Mitochondrial DNA in the Oocyte and the developing embryo
Pascale May-Panloup, Marie-Françoise Chretien, Yves Malthier, Pascal Reynier
Section II. Transmission
Chapter 4
Mitochondrial DNA and the mammalian oocyte
Eric A. Shoubridge and Timothy Wai
Chapter 5
Mitochondrial disease - its impact, aetiology and pathology
McFarland R, Taylor RW and Turnbull DM
Chapter 6
Cybrid models of mtDNA disease and transmission, from cells to mice
Ian A. Trounce, Carl A. Pinkert
Section III. The use of ARTs to regulate mtDNA disease.
Chapter 7
The use of Micromanipulation Methods as a Tool to Prevention of Transmission of Mutated Mitochondrial DNA
Helena Fulka, Josef Fulka, Jr.
Chapter 8
Difficulties and possible solutions in the Genetic Management of mtDNA disease in the pre-implantation embryo
Joanna Poulton, Pippa Oakeshott, Stephen H. Kennedy
Section IV. The effects of invasive ARTs on mtDNA transmission
Chapter 9
Impact of assisted reproductive techniques: a mitochondrial perspective from the cytoplasmic transplantion
Carol Brenner, A. J. Harvey, T. C. Gibson
Chapter 10
Nuclear Transfer – preservation of a nuclear genome at the expense of its associated mtDNA genome(s)
Emma J. Bowles, Keith H. S. Campbell, Justin C. St. John