The Lung
- 1st Edition - June 10, 2021
- Imprint: Academic Press
- Author: Ahmed El-Hashash
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 2 0 6 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 2 0 7 - 3
In the lung, more recent data have been accumulated on lung stem cell biology/function and the potential applications of stem cells in pulmonary diseases that are facilitated by th… Read more
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Request a sales quoteIn the lung, more recent data have been accumulated on lung stem cell biology/function and the potential applications of stem cells in pulmonary diseases that are facilitated by the recent development of a broad range of cutting edge in vitro and in vivo research tools and approaches, including mouse and human organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases.
Stem Cell Innovation in Health and Disease: Volume 2: The Lung, contains two major sections describing cutting edge research for understanding stem cell functions in the lung and respiratory system, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model lung diseases, through the cutting-edge research aiming to bring stem cells from bench to bedside, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of lung diseases/disorders. This book, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the lung in the real world.
- Provides intensive scientific background and most recent information on cutting edge research to understand respiratory stem cell functions and develop methods to bring stem cells from bench to bedside for different lung diseases
- Analyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and iPSC-derived alveolar epithelia cell therapy in the lung
- Contains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the lung
Researchers and practitioners in: Life Science: Stem Cell Biology Research and Biotechnology; Medicine: Stem Cell Research, Regenerative Medicine; Healthcare: Disease, Medical Education, Stem Cells, Regenerative Medicine; Engineering: Biomedical Engineering. Graduate and undergraduate students in these fields
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Epigraph
- About the author
- Foreword by Junfeng Ji
- Foreword by Alexzander A.A. Asea
- Preface
- Acknowledgments
- Chapter 1. Cutting-edge tools and approaches for stem cell research and application in pulmonary diseases
- Abstract
- Abbreviations
- 1.1 Introduction
- References
- Chapter 2. Organoid-based modality of lung development, cellular activities, and functions and lung stem cell activities/functions
- Abstract
- Abbreviations
- 2.1 Introduction
- 2.2 Organoid-based modality of lung development
- 2.3 Organoid-based modality of lung cellular activities, processes, and functions
- 2.4 Organoid-based modality of lung stem cell activities and functions
- 2.5 Conclusion and future directions
- References
- Chapter 3. Lung organoid culture system in pulmonary pathology and drug screening: an innovative test bed for basic and translational approaches
- Abstract
- Abbreviations
- 3.1 Introduction: lung organoid culture as innovative test bed for basic and translational approaches
- 3.2 Regenerative potentials of lung organoid cultures
- 3.3 Organoid-based modality of pulmonary diseases
- 3.4 Lung organoids as innovative test bed for drug development, screening, and therapeutics
- 3.5 Conclusions and future directions in lung organoid systems
- References
- Chapter 4. Stem cell-driven tissue engineering in lung engineering, regeneration, and diseases
- Abstract
- Abbreviations
- 4.1 Introduction: stem cell-driven tissue engineering
- 4.2 Roles of decellularized scaffolds in lung engineering and regeneration
- 4.3 Cells used for the repopulation of lung scaffold
- 4.4 The role of bioreactor designs in lung engineering and regeneration
- 4.5 Evaluation of the current data of lung engineering
- 4.6 Role of cell phenotype variety in the lung engineering
- 4.7 Function of engineered lungs ex vivo
- 4.8 Function of engineered lungs in vivo
- 4.9 Translation of decellularized lung scaffolds into accessible products with clinical applications
- 4.10 Conclusions and future direction
- References
- Chapter 5. Applications of innovative gene-editing technologies in respiratory diseases
- Abstract
- Abbreviations
- 5.1 Introduction to gene editing
- 5.2 CRISPR/Cas9 gene-editing technology and respiratory disorders/diseases
- 5.3 Applications of CRISPR/Cas9 genome editing in pulmonary cystic fibrosis
- 5.4 Applications of CRISPR/Cas9 gene editing in surfactant dysfunction/deficiency disorders
- 5.5 Applications of CRISPR/Cas9 gene editing in alpha-1 antitrypsin deficiency
- 5.6 Applications of CRISPR/Cas9 gene editing in other pulmonary diseases
- 5.7 Summary and conclusions and future direction
- References
- Chapter 6. Induced pluripotent stem cells in the modeling and therapy of lung diseases and airway production
- Abstract
- Abbreviations
- 6.1 Induced pluripotent stem cells
- 6.2 Induced pluripotent stem cell-derived airway tissues
- 6.3 Use of induced pluripotent stem cells in the therapy of lung diseases
- 6.4 Modeling of lung disease in vitro
- 6.5 Conclusion
- References
- Chapter 7. The gold standard embryonic stem cells in lung repair, regeneration and diseases
- Abstract
- Abbreviations
- 7.1 Introduction
- 7.2 The need for stem cell-based repair/regeneration of the lung
- 7.3 Embryonic stem cell-derived lung cells
- 7.4 Application of embryonic stem cells and their derived alveolar epithelial cells in lung repair and regeneration
- 7.5 Conclusion
- References
- Chapter 8. Hematopoietic stem cell roles in the treatment of respiratory diseases
- Abstract
- Abbreviations
- 8.1 Hematopoietic stem cells
- 8.2 Hematopoietic stem cell and lung diseases
- 8.3 BM-derived stem cell engraftment and relevance
- 8.4 The BM-derived stem cell/progenitor cells and relevance for lung disorders and diseases
- 8.5 Conclusion, perspectives, and future directions for lung tissue repair
- References
- Chapter 9. Preclinical and clinical applications of mesenchymal stem cell-based therapy in pulmonary diseases
- Abstract
- Abbreviations
- 9.1 Introduction
- 9.2 Molecular mechanisms underline MSC-based therapy of lung diseases
- 9.3 Mesenchymal stem cell therapeutic potentials in treating respiratory diseases
- 9.4 Prolonging the therapeutic effects of transplanted MSCs in the injured lung
- 9.5 Conclusions, future directions, and challenges of MSC-based therapy of lung diseases
- References
- Chapter 10. Endothelial progenitor cells in pulmonary diseases, repair and regeneration
- Abstract
- Abbreviations
- 10.1 Introduction
- 10.2 Circulating endothelial progenitor cell biology
- 10.3 The role of EPC cells in pulmonary hypertension associated with heart failure
- 10.4 The involvements of EPC cells in pulmonary arterial hypertension
- 10.5 Therapeutic approaches for pulmonary arterial hypertension using EPCs
- 10.6 The role of EPC cells in chronic obstructive pulmonary disease and pulmonary emphysema
- 10.7 Conclusion
- References
- Chapter 11. General discussion, conclusion remark, and future direction
- Abstract
- Abbreviations
- 11.1 Introduction
- 11.2 Advances of CRISPR/Cas9-based genetic editing/engineering and pulmonary organoid culture and their roles in pulmonary diseases: current challenges and future prospective
- 11.3 Role of different stem cell types in lung repair, regeneration, and diseases
- References
- Index
- Edition: 1
- Published: June 10, 2021
- No. of pages (Paperback): 174
- No. of pages (eBook): 174
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128212066
- eBook ISBN: 9780128212073
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Ahmed El-Hashash
Dr. Ahmed Hashash is currently Endowed Chair and Distinguished Professor at Elizabeth City State University, campus of the University of North Carolina (UNC). He received his PhD from Manchester University, UK. Dr. Hashash was a fellow of the California Institute of Regenerative Medicine (CIRM) and New York University Medical School (MSSM), USA. He was Assistant Professor and Principal Investigator of Stem Cell & Regenerative Medicine at School of Medicine University of California, USA. Dr Hashash was Associate Professor of Biomedicine at the University of Edinburgh (UK) Zhejiang Intl. campus and Texas A &M University, USA from 2017 to 2025. He has published more than 40 papers in reputed international journals, 10 books with Elsevier and Springer and over 20 book chapters, and is serving as an editorial board member of repute.
Affiliations and expertise
Endowed Chair, Distinguished Professor, University of North CarolinaRead The Lung on ScienceDirect