The Liver Graft Before Transplantation
Defining Outcome After Liver Transplantation
- 1st Edition - November 15, 2023
- Imprint: Academic Press
- Editor: Xavier Verhelst
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 6 5 5 - 6
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 6 5 6 - 3
The Liver Graft Before Transplantation: Defining Outcome After Liver Transplantation provides a comprehensive overview of pretransplant assessment and conditioning of liver gra… Read more
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Request a sales quoteThe Liver Graft Before Transplantation: Defining Outcome After Liver Transplantation provides a comprehensive overview of pretransplant assessment and conditioning of liver grafts to guide the best strategy for successful transplantation and better outcomes for patients. Sections provide an overview of the history and indications for liver transplantations as well as coverage of current practices used in transplantation. Next, donor and liver graft assessment are discussed with specific coverage of diseases that carry a risk of recurrence after liver transplantation, including hepatocellular carcinoma, NASH, primary biliary cholangitis, primary sclerosing cholangitis, and viral hepatitis.
Finally, the impact of the use of suboptimal liver grafts and clues to make the right trade-off between benefit and risk are discussed. This is the perfect reference for clinicians who need a comprehensive, clinically relevant overview of pretransplant assessment and conditioning of liver grafts and want to know what to expect in future years.
- Provides a comprehensive overview of pretransplant assessment and conditioning of liver grafts in one reference
- Provides the latest information in the rapidly evolving field of machine perfusion
- Includes expert opinions that help readers understand and anticipate issues to be addressed regarding the donor and the allograft before transplantation
Clinicians and Transplant Surgeons looking for a comprehensive overview of how to assess the quality of liver graft quality, Researchers interested in improving pre-transplant graft quality, Fellows in hepatology, nurses, people in training to become surgeons or clinicians, transplant coordinators, intensive care workers
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Part 1: Introduction: A history of liver transplantation
- Chapter 1 Introduction, history
- Introduction
- References
- Chapter 2 Current practice in liver transplantation
- Abstract
- The place of liver transplantation in the treatment of liver diseases
- Liver transplantation worldwide
- Different categories of donors in different geographic areas
- Living donors
- The burden of disease recurrence and posttransplant complications
- Perspectives beyond liver transplantation
- Reasons why to focus on the liver graft before transplantation
- References
- Chapter 3 Outcome after liver transplantation
- Abstract
- Introduction
- Outcomes
- Outcome predictors
- Frailty
- Conclusion
- References
- Chapter 4 Living donation in liver transplantation: Overview of history, indications, and specific aspects of living donation in liver transplantation
- Abstract
- Historical overview
- Indications to LDLT
- Contraindications
- Peculiar aspects of living donors in living donation
- References
- Part 2: Assessment of a liver graft
- Chapter 5 Assessment of a donor for liver transplantation
- Abstract
- Potential donor assessment
- Primary disease recurrence
- Transmission of diseases through the liver graft
- References
- Chapter 6 Assessment of a liver graft
- Abstract
- Introduction
- Available tools to assess the liver graft
- The place for biomarkers in the evaluation of the liver graft
- Conclusion
- References
- Chapter 7 Nonmechanical preservation and allocation of liver grafts
- Abstract
- Introduction
- Preservation solutions
- Principles and basic elements of preservation solutions
- Comparison of various (cold storage) preservation solutions
- Prediction and allocation models
- History of liver allocation
- Ethical considerations on organ allocation
- Prediction models
- References
- Chapter 8 Liver procurement: DBD, DCD, and living donation
- Abstract
- Introduction
- The importance of ischemia time on the quality of the donor’s liver
- Liver-specific requirements for preservation
- The donor after brain death
- Extended criteria donors
- The donor after cardiac death (DCD donor)
- Normothermic regional perfusion (NRP) and normo- (NMP) or hypothermic machine perfusion (HMP)
- Splitting the donor liver for split liver transplantation (SPLT)
- Living donor liver transplantation (LDLT)
- References
- Chapter 9 The use of machine perfusion in liver transplantation
- Abstract
- Introduction
- Ischemia reperfusion injury (IRI)
- Techniques of machine perfusion
- Clinical evidence
- Viability assessment
- Conclusion
- References
- Chapter 10 Emerging treatments in graft reconditioning beyond machine perfusion
- Abstract
- Introduction
- Pathophysiology of ischemia-reperfusion injury
- Factors that aggravate ischemia-reperfusion injury
- The role of perfusate as treatment
- Emerging treatments during ex vivo machine perfusion
- Defatting strategies
- RNA-inhibition techniques
- Discussion
- References
- Index
- Edition: 1
- Published: November 15, 2023
- No. of pages (Paperback): 250
- No. of pages (eBook): 350
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323996556
- eBook ISBN: 9780323996563
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Xavier Verhelst
Prof. Dr. Xavier Verhelst, MD, PhD, is a senior hepatologist at the Gastrointestinal and Liver Diseases Department at Ghent University Hospital. Dr. Verhelst is a member of the Global PBC Study Group for primary biliary cholangitis, the International PSC Study Group for primary sclerosing cholangitis (iPSCsg), and the Vascular Liver Disease Group (VALDIG) for vascular liver disease. He has been involved as a primary or subinvestigator in numerous phase I, II, and III clinical studies for new therapies in patients with viral hepatitis, primary liver tumors, primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), autoimmune hepatitis, and liver transplantation. He has given lectures at national and international conferences. He is the author and coauthor of more than 100 peer-reviewed publications. He is a member of the Board of the Flemish Association for Gastroenterology and a member of the Belgian Association for the Study of the Liver, the European Association for the Study of the Liver (EASL), and Belgian Transplant Association.
Affiliations and expertise
Senior Hepatologist, Gastrointestinal and Liver Diseases Department, Ghent University Hospital, BelgiumRead The Liver Graft Before Transplantation on ScienceDirect