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The Innate Immune System: A Compositional and Functional Perspective focuses on the components and functionality of the innate immune system, detailing how they work in their own… Read more
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Immediately download your ebook while waiting for your print delivery. No promo code needed.
The Innate Immune System: A Compositional and Functional Perspective focuses on the components and functionality of the innate immune system, detailing how they work in their own right, and then progressing to cover their relevance to disease and how they interface with the adaptive response.
Despite the growing appreciation of the importance of the innate immune system, many classical immunology books still focus predominantly on the adaptive immune response. Not only is this unbalanced, but it fails to reflect the growing synergy between the activation and function of the innate response and the final nature of adaptive response. This book fills the gap in knowledge that is needed to fully understand and appreciate the topic.
Researchers and students in immunology. It would also be appropriate as a general introduction to innate immunity for graduate students and researchers moving into the field from alternative backgrounds
Section 1. A Snapshot of the Innate Immune System
Section 2. Immune Cells and the Process of Pattern Recognition
Section 3. Effector Mechanisms and Cellular Outputs
Section 4. Integrated Innate Immunity—Combining Activation and Effector Functions
Section 5. Connecting the Innate and Adaptive Immune Responses
Section 6. The Innate Immune System in Health and Disease
TM
In 2008 Dr. Monie was awarded a prestigious Wellcome Trust Research Career Development Fellowship to run his own research group at the University of Cambridge. Focussing on the cytoplasmic NOD-like receptor family of PRRs Dr Monies’ research has subsequently contributed to improving our understanding of NLR function in health and disease. Specifically he has advanced our knowledge on how these proteins are activated by their ligands, how they interact with one another to mediate signalling in the cell, how they form macromolecular complexes in the cell, and how they contribute to the pathogenesis of inflammatory diseases such as Blau syndrome and Crohns’ Disease. He has recently started working with MRC Human Nutrition Research to more thoroughly study PRRs in the intestinal tract and the impact of nutrition on PRR function.