The immune system

Preface Foreword: Clippings from One Immunologist's JournalChapter 1 Introduction I. What Makes An Immune System Work? II. The Language of Immunology III. Why Read On? Chapter 2 Evolutionary Origins of the Immune System I. An Essential Assumption: the Immune System Evolved from Amoebae II. Amoebae Begin to Fight Back Against Intracellular Parasites III. Specificity Demands One Function Per Cell IV. The Big Evolutionary Leap V. Two New Effector Functions: An Evolutionary Puzzle VI. Merging Evolution with the Present Immune System The Take-Home Message Chapter 3 the Self-Nonself Discrimination I. Two Laws of the Immune System and Their Corollaries II. A Requirement for Two Signals III. "Help": A Property of T Cells or B Cells? IV. From Principles to Practice V. Associative Antigen Recognition VI. Mononuclear Phagocytes and the Self-Nonself Discrimination VII. The Paradox of Essential Anti-Self Immunoglobins VIII. Acquired Self-Destruction The Take-Home Message Chapter 4 A Cells and Immunoglobins I. Immunoglobins as Proteins II. The Organization and Reorganization of Genes III. Receptors and Effectors IV. Diversity and Dispersion of Combining Sites V. Haplotype Exclusion VI. The Protecton: A Module of B-Cell Function The Take-Home Message Chapter 5 T Cells I. Defensive T Cells II. Regulatory T Cells III. Which T Cells Show Restricted Recognition? IV. How Is Restrictive Recognition Accomplished? V. the Phenomena of Restrictive Recognition VI. The Organization and Reorganization of VT Genes VII. The Size of a Functional T-Cell Repertoire The Take-Home Message Chapter 6 Interleukins I. Interleukins and the Self-Nonself Discrimination II. Interleukins and Killer T Cells III. Interleukins and B Cells IV. Immunological Memory The Take-Home Message Chapter 7 the MHC: Structure and Function I. The Gene Complex II. The CLASS I and CLASS II Gene Products III. The Polymorphism Problem IV. The "Immune Response" (IR-1) Gene Effect V. Antigen Processing The Take-Home Message Chapter 8 Nonimmune Effector Functions I. Complement II. Mononuclear Phagocytes III. Mast Cells, Platelets, Histamines, and Allergy The Take-Home Message Chapter 9 Lymphoid Organs I. An Overview II. The Thymus: A Special Organ for T Cells III. Lymphoid Follicles in Spleen and Nodes The Take-Home Message Chapter 10 Other Views View I. An Idiotype Network Regulates the Immune System View II. Suppression Regulates the Self-Nonself Discrimination View III. Restricting Elements Make the Self-Nonself Discrimination View IV. There Are Many Ways to Become Unresponsive to Self View V. T Cells Recognize an Interaction Antigen View VI. Antigen Processing Is Obligatory View VII. Receptor Aggregation Signals the B Cell The Take-Home Message Index