The Human Hypothalamus
Neuroendocrine Disorders
- 1st Edition, Volume 181 - July 4, 2021
- Imprint: Elsevier
- Editors: Dick F. Swaab, Ruud M. Buijs, Paul J. Lucassen, Ahmad Salehi, Felix Kreier
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 0 6 8 3 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 0 6 8 4 - 3
The Human Hypothalamus: Neuroendocrine Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and ner… Read more
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The Human Hypothalamus: Neuroendocrine Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume summarizes the role of the hypothalamus in neuroendocrine disorders, identifying the mechanism of action, disorder etiology, and best practices for assessment and treatment. Disorders covered include pituitary hypothalamic disorders of development and growth, hypothalamic tumor related disorders, hypothalamic autoimmune disorders and infection, disorders of vasopressin, water and sodium homeostasis, eating disorders, and gonadotropic hormone regulation disorders.
- Discusses the importance of the hypothalamus in human growth and development
- Reviews hypothalamic related tumors, as well as pituitary, autoimmune, vasopressin and hormone regulation disorders
- Includes metabolic and eating disorders
- Identifies mechanisms of disease action and etiology
- Provides best practice information for assessment and treatment
Clinical neurologists, researchers in neurology
1. Introduction: The human hypothalamus and neuroendocrine disorders
SECTION 15 Structural disorders of the hypothalamo-pituitary region
2. Pituitary stalk interruption syndrome
3. Empty sella syndrome: Multiple endocrine disorders
4. Pituitary dysfunction after aneurysmal subarachnoidal hemorrhage
5. Septo-optic dysplasia
SECTION 16 Tumors of the hypothalamus
6. Hypothalamic hormone-producing tumors
7. Craniopharyngiomas primarily affecting the hypothalamus
SECTION 17 Neuroimmunological disorders
8. The stress-axis in multiple sclerosis: Clinical, cellular, and molecular aspects
9. Neuroendocrine manifestations of Langerhans cell histiocytosis
10. Neuroendocrine manifestations of Erdheim–Chester disease
11. Hypothalamitis and pituitary atrophy
12. Narcolepsy Type I as an autoimmune disorder
13. Neuromyelitis optica, aquaporin-4 antibodies, and neuroendocrine disorders
14. Antibodies against the pituitary and hypothalamus in boxers
15. Autoimmune diabetes insipidus
SECTION 18 Drinking disorders
16. Neuroimaging of central diabetes insipidus
17. Differential diagnosis of familial diabetes insipidus
18. The vasopressin–aquaporin-2 pathway syndromes
19. Adipsic diabetes insipidus
20. Animal models for diabetes insipidus
21. Nocturnal enuresis in children: The role of arginine–vasopressin
SECTION 19 Eating disorders
22. Monogenic human obesity syndromes
23. Hypothalamic microinflammation
24. Glucose and fat sensing in the human hypothalamus
25. Hypothalamus and neuroendocrine diseases: The use of human-induced pluripotent stem cells for disease modeling
26. Prader–Willi syndrome: Hormone therapies
27. Transcriptomics of the Prader–Willi syndrome hypothalamus
28. Disorders of hypothalamic function: Insights from Prader–Willi syndrome and the effects of craniopharyngioma
29. Animal models for Prader–Willi syndrome
30. Is there a hypothalamic basis for anorexia nervosa?
SECTION 20 Reproduction, olfaction and sexual behavior
31. Sexual differentiation of the human hypothalamus: Relationship to gender identity and sexual orientation
32. Klinefelter syndrome or testicular dysgenesis: Genetics, endocrinology, and neuropsychology
33. Neurobiology of puberty and its disorders
- Edition: 1
- Volume: 181
- Published: July 4, 2021
- Imprint: Elsevier
- Language: English
DS
Dick F. Swaab
Dick Swaab (1944) earned his medical and doctoral degrees at the University of Amsterdam, where he became involved in brain research during his third year of medical school. He was Director of the Netherlands Institute for Brain Research from 1978 to 2005. Since 1979 he is Professor of Neurobiology at the Medical Faculty, University of Amsterdam.
In 1985, Dr. Swaab founded the Netherlands Brain Bank (NBB) to serve as a source of clinically and neuropathologically well-documented research tissue. Since its founding, the Brain Bank has provided samples from more than 4,000 autopsies to 500 research groups in 25 countries. He was director of the NBB until 2005.
He is Leader Research team Neuropsychiatric Disorders, Neth. Inst for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences (KNAW). Swaab is also appointed for 2011-2017 Chao Kuang Piu Chair of Zhejiang University, Hangzhou, P.R. China.
His major research interests focus on, sexual differentiation of the human brain in relation to gender identity and sexual orientation, aging of the brain, Alzheimer’s disease, the neurobiological basis of depression, suicide and eating disorders. He has published over 540 papers in SCI journals, authored more than 200 chapters in books, and edited more than 60 books. Swaab mentored 84 PhD students from which 16 are now full professor. He is “Companion in the Order of the Dutch Lion”, bestowed by her Royal Majesty Queen Beatrix of the Netherlands. In 2008 Swaab obtained the Academy medal for his role in national and international neuroscience.
Dick Swaab is author of the 2 volume monograph The Human Hypothalamus that appeared in the Handbook of Clinical Neurology series, Elsevier, Amsterdam (1000 pp) and the Dutch best seller We are our Brains (450.000 copies sold), that is translated in 14 languages. A children's version of the book (You are your brains) has also appeared in Dutch in 2013 and Russian (2014). Swaab's H-factor is 76.
Affiliations and expertise
Netherlands Institute for Brain Research, University of Amsterdam, Amsterdam, The NetherlandsRB
Ruud M. Buijs
Dr. Ruud M. Buijs is head of the Physiology department of the I.I.Biomedicas at the UNAM university and leader of the group Hypothalamic Integration Mechanisms. In that group, the scientists study how the brain and body interact with each other, and hereby the attention is focussed on autonomic and hormonal regulation of body functions under the influence of the biological clock of the brain.
Affiliations and expertise
Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico D.F.PL
Paul J. Lucassen
Paul J. Lucassen did his PhD in 1995 on Alzheimer’s Disease at the Netherlands Institute for Brain Research in Amsterdam.
After a.o. a postdoc in Leiden, he became Full Professor of Brain Plasticity in 2011 at the Swammerdam Institute for Life Sciences (SILS) of the University of Amsterdam, The Netherlands.
His group studies molecular, nutritional, pharmacological and environmental regulation of brain plasticity. They combine molecular tools, in vitro/vivo model systems, human brain tissue, cohort studies and brain imaging. A major focus is on adult neurogenesis and cognition in relation to; (early life) stress, exercise, enrichment, depression, brain insults and dementia.
Affiliations and expertise
Swammerdam Institute for Life Sciences (SILS) - Center for Neuroscience, University of Amsterdam, Amsterdam, The NetherlandsAS
Ahmad Salehi
Ahmad Salehi is affiliated with Stanford Medical School, Department of Psychiatry & Behavioral Sciences, in Palo Alto, CA, United States.
Affiliations and expertise
Stanford Medical School, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA, United StatesFK
Felix Kreier
Felix Kreier is a pediatrician and affiliated with OLVG Hospitals in Amsterdam, The Netherlands.
Affiliations and expertise
OLVG Hospitals, Amsterdam, The NetherlandsRead The Human Hypothalamus on ScienceDirect