The Herpesviruses

List of Contributors

Preface

Chapter 1 Herpes: History and Classification

I. Introduction

II. Development of the Concept of the Herpes Group of Viruses, 500 B.C. to 1972 A.D.

III. Subclassification of the Herpesviruses

IV. Summary and Conclusions

References

Chapter 2 Morphology

I. Introduction

II. Morphology of Particles of Herpes Simplex Virus

III. Other Herpesviruses

IV. Morphology and Clinical Diagnosis

V. Morphology and Classification of Herpesviruses

References

Chapter 3 The Physical and Chemical Properties of the Herpesviruses


1. Introduction

II. The Herpes Virion—Physical Properties

III. The Herpes Virion—Chemical Properties

IV. Resistance of the Herpesviruses to Inactivation

V. Conclusion

References

Chapter 4 Replication—Biological Aspects

I. Introduction

II. Host Range

III. Environmental Factors Affecting Virus Growth

IV. Virus Growth Cycle

V. Cytopathogenic Effect and Quantitation of Virus Growth

VI. Variation and Genetics

References

Chapter 5 Replication of the Viruses—Morphological Aspects

I. Introduction

II. Attachment and Penetration

III. Growth of the Virus

IV. Conclusion

References

Chapter 6 Replication—Biochemical Aspects

I. Introduction

II. Effect of Infection on Macromolecular Synthesis

III. RNA Synthesis

IV. DNA Synthesis

V. Protein Synthesis

VI. Membrane Alterations

VII. Virion Assembly

VIII. Abortive Infection

IX. Enzymology of the Infected Cells

X. Control of the Infective Process

References

Chapter 7 Immunological Relationships

I. Serological Tests

II. Immunology of Herpesviruses

References

Chapter 8 Interference and Interferon with Respect to Herpesviruses

I. Introduction

II. Interference—Possibly Mediated by Interferon

III. Interference Not Mediated by Interferon

IV. Relative Resistance of Herpesviruses to Interferon and Poly rI:Poly rC

V. Induction of Interferon

VI. Dual Infections

VII. Conclusion

References

Chapter 9 Persistent and Latent Infections

I. Introduction and Definition of Terms

II. In Vivo Studies

III. Latency In Vitro

IV. Transformation of Cells In Vitro

V. Recapitulation

References

Chapter 10 Herpes Simplex Virus

I. Introduction

II. Pathology and Pathogenesis

III. Epidemiology

IV. Immunity to Herpesvirus

V. Clinical Manifestations of Herpesvirus Type 1

VI. Clinical Manifestations of Herpesvirus Type 2

VII. Herpesvirus Type 2 and Cervical Cancer

VIII. Laboratory Diagnosis

IX. Conclusion

References

Chapter 11 Varicella—Zoster Viruses

I. Introduction

II. Clinical Features and Diagnosis

III. Pathology and Pathogenesis

IV. Immunity

V. Epidemiology

References

Chapter 12 Cytomegaloviruses

I. Introduction

II. Disease States Associated with CMV (Essential Clinical Features)

III. CMV in Animals

IV. Pathogenesis and Pathology

V. Immunity

VI. Epidemiology

VII. Treatment, Prevention, and Control

VIII. Summary

References

Chapter 13 The Simian Herpesviruses

I. Introduction

II. Introduction to and Origin of the Simian Herpesviruses

III. Nature of Infections Produced

IV. Distribution and Prevalence

V. Epidemiological Features

VI. Diagnosis of Simian Infections

VII. Prevention and Control

VIII. Simian Herpesviruses as Zoonotic Agents

IX. Epidemiologic Features of H. simiae Infection in Man

X. Pathogenesis in Man

XI. Clinical Features

XII. Clinical and Laboratory Diagnosis

XIII. Preventive Measures

References

Chapter 14 Viruses of Other Vertebrates

I. Introduction

II. Bovine Herpesvirus-1 Infections: Infectious Bovine Rhinotracheitis, Infectious Pustular Vulvovaginitis

III. Bovine Herpesvirus-2 Infection: Bovine Herpesvirus Mammillitis

IV. Equine Herpesvirus Infections: Equine Rhinopneumonitis, Equine Coital Exanthema

V. Porcine Herpesvirus Infection: Pseudorabies

VI. Canine Herpesvirus Infection

VII. Feline Herpesvirus Infection: Feline Viral Rhinotracheitis

VIII. Cottontail Herpesvirus Infection

IX. Herpesvirus Infection of Chickens: Infectious Laryngotracheitis

References

Chapter 15 Herpesviruses of Lower Vertebrates

I. Introduction

II. Reptilian Hosts

III. Teleostean Fish Hosts

IV. Specific Pathogen-Free Test Animals

References

Chapter 16 The Epstein-Barr Virus

I. History

II. Virus-Cell Relationships

III. EB Virus and Infectious Mononucleosis

IV. Relationship between EB Virus and Burkitt's Lymphoma (BL)

V. Relationship between EB Virus and other Lymphoproliferative Diseases

VI. Relationship between EB Virus and Nasopharyngeal Carcinoma

VII. Cell-Mediated Immunity

VIII. Discussion

References

Chapter 17 Marek's Disease

I. Introduction

II. Clinical Disease

III. Pathology

IV. Etiology

V. Virology

VI. Epizootiology

VII. Control

References

Chapter 18 Herpesvirus saimiri

I. Introduction

II. Studies in Vitro

III. Natural History

IV. Pathogenesis of Diseases Caused by Herpesvirus saimiri

V. Discussion

VI. Addendum

References

Chapter 19 The Lucké Renal Carcinoma of the Frog

I. Introduction

II. The Tumor

III. Properties of the Lucké Tumor-Associated Herpesvirus

References

Chapter 20 Chemotherapy—Molecular Aspects

I. 5-Iodo-2'-Deoxyuridine (IUdR, IdUrd, IdU, Idoxuridine)

II. 6-Azauracil Ribonucleoside (6-Azauridine)

III. 5-Ethyl-2'-Deoxyuridine

IV. Trifluoromethyl-2'-Deoxyuridine

V. 1-ß-D-Arabinofuranosyl Cytosine (Arabinosyl Cytosine, Cytosine Arabinoside)

VI. 9-ß-D-Arabinofuranosyl Adenine (Adenine Arabinoside)

VII. Conclusion

References

Chapter 21 Chemotherapy of Herpesviruses—Clinical Aspects

I. Introduction

II. Antiviral Chemotherapy in Experimental Herpes Infections of Laboratory Animals

III. Herpetic (HSV) Keratitis in Man

IV. Herpesvirus Infections with Prominent Skin Lesions (Simplex, Zoster, Varicella)

V. Herpesvirus Encephalitis

VI. Conclusions

References

Author Index

Subject Index