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The Gut-Brain Axis
Dietary, Probiotic, and Prebiotic Interventions on the Microbiota
- 2nd Edition - December 7, 2023
- Editors: Niall Hyland, Catherine Stanton
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 9 7 1 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 8 3 0 2 - 0
The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota, Second Edition presents the most advances on how the gut microbiome influences central n… Read more
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Request a sales quoteThe Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota, Second Edition presents the most advances on how the gut microbiome influences central nervous system and brain function introduced in the first edition. The book also describes how environmental influences which affect the microbiota, including, diet, exercise, and early-life, impact on the gut-brain axis.
The second edition contains new chapters on metabolomics and the gut-brain-axis; dietary factors in the maintenance of a healthy brain ; the role of gut microbes in neurodegenerative disorders; the link between exercise and the gut-brain-axis; and infant Nutrition, the microbiome and neurodevelopment. In addition, the second edition presents coverage of mechanisms underlying neurological disease; approaches to investigate the role of the microbiome in brain and behavior, and 'next generation' probiotics and prebiotics.
The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota, Second Edition continues to be the “go-to” resource for further exploration of the microbiota.
- Includes five new chapters focused on metabolomics and the gut-brain axis; dietary polyphenols to maintain healthier brain measures and cognitive function; the role of gut microbes in neurodegenerative disorders, exploration of exercise and the gut-brain axis, and coverage of infant nutrition, the microbiome, and neurodevelopment
- Addresses the role of the microbiota in several significant disorders characterized by disruption of the gut-brain axis
- Focuses on specific ways by which the microbiota can be manipulated to influence gut-brain communication
- Examines common mechanisms and pathways by which the microbiota may influence brain and behavior and how environmental factors influence the microbiome
- Discusses strategies to explore the contribution of the microbiome to the gut-brain axis; methods to enhance therapeutic strategies targeted toward the microbiota; and regulatory consideration
Professors, Associate Professors, PostDocs, Graduate Students, and Team Leaders researching: Gut-brain axis, Neuro-Gastroenterology, Microbiology, Nutrition, Food Science, Psychiatry, Behavioral Sciences, Neuroscience, Translational Research
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1. Correlating the Gut Microbiome to Health and Disease
- Introduction
- Gut Microbiota and Immune System-Related Diseases
- Gut Microbiota and Intestinal Diseases
- Gut Microbiota and Diseases of the Nervous System
- Gut Microbiota and Metabolic Diseases
- Overview of Some Potential Therapies That Are Currently Being Used to Re-Establish a Healthy Gut Microbiota
- Conclusion
- Chapter 2. Importance of the Microbiota in Early Life and Influence on Future Health
- Early Life Development of the Gut–Brain Axis
- Adverse Early Life Events
- Disorders of Early Life Stress
- Microbiota-Targeted Interventions for Disorders of the Gut–Brain Axis
- Concluding Remarks
- Chapter 3. The Microbiome and Aging
- Gut Microbiome and Health: A General Introduction
- Aging is of Special Medical and Microbiome Importance
- Microbiome Alterations and Aging—Cohort Studies
- The Special Case of Centenarians
- Aging and Health: Cohort and Observational Studies
- Granular Analysis of Microbiome Shifts in Aging and Unhealthy Aging
- Interventions to Improve Microbiome and Aging
- Summary and Perspectives
- Chapter 4. Influence of the Microbiota on the Development and Function of the “Second Brain”—The Enteric Nervous System
- Introduction
- Development of the Enteric Nervous System
- Microbial Colonization of the GI Tract
- Influence of Microbiota on the Development of the ENS
- Proposed Mechanisms for Microbial–ENS Interactions
- Clinical Relevance
- Conclusions
- Chapter 5. Altering the Gut Microbiome for Cognitive Benefit
- Introduction
- Factors Influencing Cognition
- Probiotic Interventions and Cognitive Function
- Prebiotic Intervention and Cognitive Function
- Conclusions
- Chapter 6. Gut Microbiota and Metabolism
- Introduction
- Gut Microbiota Composition and Metabolic Disorders
- Prebiotics and Probiotics as Tools to Modulate Dysbiosis in Metabolic Diseases
- Conclusions
- Chapter 7. The Influence of Gut Microbiota in Psychosis
- Introduction
- Gut–Brain Pathways in Psychosis
- Inflammation and Immunity in Psychotic Disorders
- Diet and Psychotic Disorders
- Metabolic Dysfunction and Psychotic Disorders
- Hypothalamic–Pituitary–Adrenal Axis
- Evidence of Alterations in the Gut Microbiome in Psychotic Disorders
- Microbiota–Gut–Brain Interventions in Psychosis
- Summary
- Chapter 8. Microbiota–Gut–Brain Axis in Neurodevelopmental Disorders
- Introduction
- Interactions Between the Gut Microbiome and Social Behavior
- Microbial Dysbiosis in Autism Spectrum Disorder
- Targeting the gut Microbiome to Treat Symptoms of ASD
- Dietary Interventions in ASD
- Conclusion and Perspectives
- Chapter 9. Gut Microbes in Parkinson's Disease: Opportunities for Microbial-Based Therapies
- Introduction
- Gut Dysfunction and Gut Dysbiosis in PD
- Mechanisms of Microbiota-Gut–Brain Axis Modulation in PD
- Targeting the Gut–Brain Axis in PD via the Microbiota
- Future Perspectives/Conclusion
- Chapter 10. Exercise and the Brain–Gut Axis
- Introduction
- Physical Exercise as a Health Modulator
- Physical Exercise and the BrainGut Axis
- Conclusions
- Chapter 11. Global and Epidemiological Perspectives on Diet and Mood
- Introduction
- Changes to the Food Supply and Global Impact on Health
- Nutrients and Mental Health
- Diet Quality and Mental Health
- The Importance of Diet to Mental Health Across the Lifespan
- Intervention Studies
- Clinical Applications
- Conclusions
- Chapter 12. Dietary Interventions and Brain–Gut Disorders
- Introduction
- Diet and IBS
- Modulation of the Gut Microbiome by Diet or Dietary Supplements in IBS
- Conclusions
- Chapter 13. Pediatric Nutrition: Implications for the Developing Microbiota–Gut–Brain Axis
- Introduction
- Human Milk and Neurocognitive Development
- Human Milk, Microbiome Development, and the MGBA
- The MGBA and Neurocognition in Early Life
- The Pig as a Biomedical Model
- The Pig as a Model to Study Early Life Neurocognitive Development
- Investigation of Bioactives on the MGBA in Young Pigs
- Overall Conclusions
- Chapter 14. Dietary Polyphenols to Maintain Healthier Brain Measures and Cognitive Function, as Mediated by Gut Microbiota Metabolites
- Introduction
- What are Polyphenols?
- Preclinical Evidence for Biological Mechanisms Mediating Brain Health Benefits
- Clinical Evidence Supporting a Potential Effect of Polyphenols on Cognitive Function
- Summary and Conclusion
- Chapter 15. Probiotics as Curators of a Healthy Gut Microbiota: Delivering the Solution
- Introduction
- Gut Microbiota Composition in Infants and Adults
- Factors Disrupting the Gut Microbiota
- Prebiotics and Probiotics
- Gut Microbiota Modulation and Health Outcomes Using Probiotics
- Conclusion
- Chapter 16. Germ-Free Animals: A Key Tool in Unraveling How the Microbiota Affects the Brain and Behavior
- Introduction
- Communication Along the Microbiota–Gut–Brain Axis
- The Microbiota–Gut–Brain Axis in Health and Disease
- The Germ-Free Mouse
- The Germ-Free Mouse and Health
- Gnotobiotics, Humanization, and Fecal Microbial Therapy
- Anxiety and Stress Responsivity
- Social, Repetitive, and Locomotor Behaviors
- Learning and Memory
- Neurochemical and Molecular Alterations
- Novel Models to Investigate the Microbiota–Gut–Brain Axis
- The Germ-Free Model: Strengths, Limitations, and Alternativies
- Chapter 17. Metabolomics and the Gut–Brain Axis
- Introduction: The Gut Microbiota–Gut–Brain Axis
- Metabolomics: Tools and Applications
- Main Classes of Microbiota-Derived Metabolites
- Gut Microbial Metabolites and Their Role in Brain Function
- Conclusions and Future Perspectives
- Chapter 18. Mining for the Next-Generation Microbiota Across the Gut–Brain Axis: A Case Study on the Translational Success of Bifidobacterium Longum APC1472
- Introduction
- A Pharmaceutical Approach to Mine Microbes and Metabolites
- Microbiota and G-Protein Coupled Receptors (GPCRs)
- Microbiota and Ghrelin Receptor Signaling
- Validation and Translation of B. longum APC1472
- Conclusion
- Chapter 19. Perspectives on Manipulating the Microbiome to Modulate the Gut-Brain Axis: Mechanisms, Causality and Translation
- Introduction
- Moving Towards Mechanisms
- Establishing Causality
- Translational Research
- Conclusions
- Index
- No. of pages: 508
- Language: English
- Edition: 2
- Published: December 7, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780323999717
- eBook ISBN: 9780323983020
NH
Niall Hyland
Niall Hyland is a Senior Lecturer in the Department of Physiology at University College Cork in Ireland and a Funded Investigator at APC Microbiome Ireland. Dr Hyland has over 20 years’ experience in gastrointestinal physiology and enteric neuroscience and his fields of interest include enteric physiology and pharmacology, the brain-gut axis, and microbiota-host interactions. He received a BSc (Hons) in Biomedical Sciences from the University of Ulster and PhD in Pharmacology from King’s College London. Dr. Hyland was a visiting fellow at the Department of Pharmacology and Experimental Therapeutics, Louisiana State University Medical Center, USA and completed postdoctoral training at the University of Calgary, Canada. He returned to Ireland in 2007. He has represented Ireland on the Steering Committee of the European Society of Neurogastroenterology and Motilty and is an Honorary Fellow of the British Pharmacological Society.
Affiliations and expertise
Senior Lecturer, Department of Physiology, University College Cork, Cork, IrelandCS
Catherine Stanton
Catherine Stanton is a Senior Principal Research Officer at Teagasc Moorepark Food Research Centre, Moorepark, Fermoy, Ireland, a Research Professor at University College Cork, College of Medicine and Health, and one of the original PI of APC Microbiome Ireland. Her research program addresses development of innovative dairy foods and probiotics that influence human health and the developing gut microbiota in early life. She has led numerous national and international grants, including the coordination of a number EU projects on various aspects of probiotics for human and animal applications.
Affiliations and expertise
Senior Principal Research Officer, Teagasc Moorepark Food Research Centre, Moorepark Fermoy; Research Professor, College of Medicine and Health, University College Cork, Cork, IrelandRead The Gut-Brain Axis on ScienceDirect