The Digestive Involvement in Systemic Autoimmune Diseases

Section I Introduction

Chapter 1. Digestive System and Autoimmunity

• 1. The Digestive System and Gut-Associated Immunity
• 2. Self-Tolerance and Autoimmunity
• 3. Tolerance Mechanisms for Autoreactive B Cells in the Bone Marrow
• 4. Tolerance Mechanisms for Autoreactive T Cells in the Thymus
• 5. Clonal Anergy and Tuning
• 6. Extrinsic Controls of Self-Reactive Lymphocytes
• 7. Limitation of Costimuli
• 8. Regulation of Self-Reactive Lymphocytes in Follicles
• 9. Tolerance at the Effector Phase
• 10. Conclusions

Chapter 2. Immunopathogenesis of Autoimmune Liver Damage

• 1. Introduction
• 2. Antigens and Antigen Responses
• 3. Molecular Mechanisms of Liver Cell Injury
• 4. Cellular Mediators of Liver Cell Injury
• 5. Genetic Predispositions

Chapter 3. Autoantibodies in Gastrointestinal Autoimmune Diseases

• 1. Antibodies in Inflammatory Bowel Diseases
• 2. Antibodies in Celiac Disease
• 3. Antibodies in Autoimmune Liver Diseases
• 4. Clinical Practice

Chapter 4. Imaging Techniques in Digestive Diseases

• 1. Introduction
• 2. Imaging Modalities
• 3. Future Prospects

Section II Autoimmune Liver Diseases

Chapter 5. Primary Biliary Cholangitis

• 1. Introduction
• 2. Epidemiological Highlights
• 3. Pathophysiological Insights
• 4. Clinical Presentations
• 5. Natural History and Prognostic Considerations
• 6. Treatment Considerations
• 7. Conclusion
• 8. Five-Year Update

Chapter 6. Autoimmune Hepatitis

• 1. Introduction
• 2. History and Epidemiology
• 3. Clinical Features
• 4. Diagnosis and Laboratory Findings
• 5. Pathophysiology
• 6. Management and Prognosis
• 7. Autoimmune Hepatitis and Liver Transplant
• 8. Conclusion

Chapter 7. Primary Sclerosing Cholangitis

• 1. Introduction
• 2. Epidemiology
• 3. Etiopathogenesis
• 4. Clinical Features
• 5. Diagnosis
• 6. Special Patient Populations
• 7. Inflammatory Bowel Disease in Primary Sclerosing cholangitis
• 8. Primary Sclerosing Cholangitis and Malignancy
• 9. Nonmalignant Complications
• 10. Natural History of Disease
• 11. Treatment
• 12. Conclusion

Section III Autoimmune Manifestations of Viral Hepatitis

Chapter 8. Systemic and Autoimmune Manifestations of Hepatitis B Virus Infection

• 1. Introduction
• 2. Hepatitis B Virus Infection
• 3. Extrahepatic Manifestations of Hepatitis B Virus Infection
• Key Points

Chapter 9. Extrahepatic Manifestations in Patients With Chronic Hepatitis C Virus Infection

• 1. Introduction
• 2. Autoantibodies and Hepatitis C Virus
• 3. Organ-Specific Autoimmune Diseases and Hepatitis C Virus
• 4. Systemic Autoimmune Diseases and Hepatitis C Virus
• 5. Hematological Diseases and Hepatitis C Virus

Chapter 10. New Antivirals for Extrahepatic Manifestations of Hepatitis C Virus: The Model of Mixed Cryoglobulinemia Vasculitis

• 1. Introduction
• 2. Treatment of Hepatitis C Virus–Mixed Cryoglobulinemia Vasculitis

Section IV Gastrointestinal Involvement of Systemic Diseases

Chapter 11. Systemic Lupus Erythematosus

• 1. Introduction
• 2. Overview of Gastrointestinal Manifestations in Systemic Lupus Erythematosus
• 3. Oral Cavity, esophagus, and Gastrointestinal Abnormalities
• 4. Main Identifiable Lupus-Related Gastrointestinal Syndromes
• 5. Lupus-Associated Pancreatitis
• 6. Other Systemic Lupus Erythematosus–Related Gastrointestinal Problems

Chapter 12. Digestive Involvement in the Antiphospholipid Syndrome

• 1. Introduction
• 2. Gastrointestinal Involvement
• 3. Hepatic Involvement
• 4. Splenic Involvement
• 5. Pancreatic Involvement

Chapter 13. Gastrointestinal Involvement in Systemic Sclerosis

• 1. Introduction
• 2. Pathogenesis of Gastrointestinal Tract Dysmotility
• 3. Esophagus
• 4. Stomach
• 5. Small Intestine
• 6. Colon and Anorectal Disorders
• 7. Patient-Reported Outcome Measures
• 8. Conclusion

Chapter 14. Gastrointestinal Involvement in Inflammatory Myositis

• 1. Introduction
• 2. Dysphagia
• 3. Gastric Involvement
• 4. Gastrointestinal Vasculitis and Inflammation
• 5. Pneumatosis Cystoides Intestinalis
• 6. Overlap With Inflammatory Bowel Disease
• 7. Overlap With Coeliac Disease
• 8. Association With Chronic Viral Infections
• 9. Diagnosis and Differential Diagnosis
• 10. Therapeutic Management

Chapter 15. Digestive Involvement in Primary Sjögren's Syndrome

• 1. Introduction
• 2. Esophageal Involvement
• 3. Gastric Involvement
• 4. Intestinal Involvement
• 5. Pancreatic Involvement
• 6. Liver Involvement

Chapter 16. Gastrointestinal Involvement in Systemic Vasculitis

• 1. Introduction
• 2. Large-Vessel Vasculitis
• 3. Medium-Sized Vessel Vasculitis
• 4. Small-Sized Vessels Vasculitis

Chapter 17. Mixed Connective Tissue Disease

• 1. Introduction
• 2. Are Gastrointestinal Features a Common Manifestation of Mixed Connective Tissue Disease?
• 3. Oral Manifestations
• 4. Esophageal Dysfunction
• 5. Bowel Manifestations
• 6. Other Conditions
• 7. Therapeutic Considerations
• 8. Conclusion

Chapter 18. Gastrointestinal Manifestations of Rheumatoid Arthritis

• 1. Introduction
• 2. Manifestations Directly Due to Rheumatoid Arthritis
• 3. Gastrointestinal Disease Resulting From Rheumatoid Arthritis Therapeutics
• 4. Mimics of Gastrointestinal Disease in Rheumatoid Arthritis
• 5. Conclusion

Chapter 19. Spondyloarthritis and Gastrointestinal Involvement

• 1. Introduction
• 2. Prevalence and Epidemiology
• 3. Etiology/Pathogenesis
• 4. Clinical Manifestations
• 5. Diagnostic Investigations
• 6. Differential Diagnosis
• 7. Treatment

Chapter 20. Intestinal Behçet's Disease

• 1. Introduction
• 2. Epidemiology
• 3. Clinical Features
• 4. Differential Diagnosis
• 5. Pathogenesis
• 6. Diagnosis
• 7. Assessment of Severity
• 8. Management
• 9. Prognosis

Chapter 21. Gastrointestinal Involvement of Sarcoidosis

• 1. Introduction
• 2. Sarcoidosis of Upper Gastrointestinal Tract
• 3. Sarcoidosis of Lower Gastrointestinal Tract
• 4. Hepatic and Splenic Sarcoidosis
• 5. Conclusion

Chapter 22. IgG4-Related Disease: Gastrointestinal Involvement

• 1. Introduction
• 2. Clinical Spectrum of IgG4-Gastrointestinal Disease
• 3. Diagnostic Approach
• 4. Therapeutic Approach

Chapter 23. Gastrointestinal Complications of Antirheumatic Drugs

• 1. Introduction
• 2. The Clinical Setting
• 3. Gastrointestinal Reactions in Autoimmune Arthropathies
• 4. Gastrointestinal Reactions in Autoimmune Arthropathies
• 5. Coxibs Versus Nonselective NSAIDs
• 6. Strategies to Minimize or Eliminate Gastrointestinal Complications
• 7. Modification of Analgesics to Prevent Gastric Complications
• 8. Conclusion