The Cytokines of the Immune System
The Role of Cytokines in Disease Related to Immune Response
- 1st Edition - June 2, 2015
- Author: Zlatko Dembic
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 1 9 9 9 8 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 4 2 0 0 1 0 - 4
The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. I… Read more
The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles.
- Supplies new ideas for basic and clinical research
- Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials
- Offers a textbook-style view on the immune system with the immunologic role of each cytokine
graduate students to scientists, researchers, teachers in microbiology, immunology, biochemistry, cell biology, medicine, cytokine biology, and odontology: clinicians in all specialties of medicine and surgery: pharmaceutical companies and their R&D divisions.
- Foreword
- Acknowledgments
- Chapter 1. Introduction—Common Features About Cytokines
- Division
- Structure
- Receptors
- Intracellular Signal Transduction
- Hormones and Cytokines
- Function
- Chapter 2. The Immune System—Definition and Development of Immunity
- Organization of the Immune System
- Humoral Innate (Nonspecific) Immunity
- Cellular Innate (Nonspecific) Immunity
- Adaptive Humoral (Specific) Immune System
- Cellular Adaptive (Specific) Immune System
- Chapter 3. Activation of Cells of the Immune System
- Activation of Immune Cells in the Periphery of the Immune System
- Specific Recognition
- Coreceptors of T Cells: CD4 and CD8
- Costimulation During T-Cell Activation
- Signal Transduction in T Cell
- Signal Transduction in the B Cell
- Signal Transduction in Mast Cells
- Further Development of Immune Cells Upon Activation
- T lymphocyte homeostasis
- Repertoire and Tolerance
- Chapter 4. The Role and Regulation of the Immune Responses
- The Course of the Immune Response
- Regulation of Immunocyte Development after Activation
- Important Control Functions of Cytokines
- The Role of Th1-Type of Immune Response
- The Role of Th2-Type of Immune Response
- The Role of Th9 Subset
- The Role of Th17 Subset
- The Role of Th22 Subset
- The Role of Th3, and Tr1 Cells
- The Role of Regulatory CD4 T Lymphocytes—Tregs
- The Role of the Tfh Subset
- Chapter 5. Cytokines of the Immune System: Interferons
- Interferon-α/β
- Interferon-γ (IFN-γ)
- Interferon-λ (IFN-λ)
- Chapter 6. Cytokines of the Immune System: Interleukins
- IL-1
- IL-2
- IL-3
- IL-4
- IL-5
- IL-6
- IL-7
- IL-8
- IL-9
- IL-10
- IL-11
- IL-12
- IL-13
- IL-14 (IL-14 does not exist in databases)
- IL-15
- IL-16
- IL-17
- IL-18
- IL-19
- IL-20
- IL-21
- IL-22
- IL-23
- IL-24
- IL-25
- IL-26
- IL-27
- IL-28 and IL-29 (Type III Interferon, λ1–3)
- IL-30
- IL-31
- IL-32
- IL-33
- IL-34
- IL-35
- IL-36
- IL-37
- IL-38
- Chapter 7. Cytokines of the Immune System: Chemokines
- About Chemokines
- The Role of Chemokines in the Immune System
- CCL Chemokines (CCL1–CCL28)
- CXCL Chemokines (1–16)
- CX3CL Chemokine
- XCL Chemokines (1–2)
- Other Features of Chemokines
- Chapter 8. Cytokines Important for Growth and/or Development of Cells of the Immune System
- TNF-α/β
- TGF-β
- TSLP (Thymic Stromal Lymphopoietin)
- KGF (Keratinocyte Growth Factor)
- SCF (Stem Cell Factor) and Growth Factors (CSF, GM-CSF, M-CSF) of Hematopoietic Lines
- LIF—Leukemia Inhibitory Factor
- CNTF—Ciliary Neurotrophic Factor
- OSM—Oncostatin M
- A Short Description of Other Cytokines that Regulate Growth and Development of Various Tissues
- Chapter 9. Theories about the Function of the Immune System
- About Scientific Theories
- Self–Nonself Discrimination
- The “Pathogen-Associated Molecular Pattern (Pamp) Recognition” Theory (Janeway)
- Idiotypic Networks and Suppression (Jerne)
- The “Danger” Model (Matzinger)
- The “Integrity” Model (Dembic)
- Other Theories About Immunity
- Index
- Edition: 1
- Published: June 2, 2015
- Language: English
ZD
Zlatko Dembic
Dr. Zlatko Dembic, a distinguished scientist and medical doctor, has dedicated his career to exploring the intersections of medicine and biology, particularly in molecular and cellular immunology. Over the last two decades of the 20th century, he worked at prestigious institutions such as the Max-Planck-Institute for Biology in Germany, the Basel Institute for Immunology in Switzerland, and Hoffman-La Roche AG. His team was the first to identify genes underlying T-cell specificity and recognition, and they led the molecular cloning of key human cytokine receptors like the interferon-gamma receptor and the tumor necrosis factor receptor-2. In 1995, Dr. Dembic joined the Institute of Immunology at the University of Oslo, expanding his research to include T-cell development, cancer immunobiology, and immunogenetics. He proposed the "integrity" model of the immune system, emphasizing immunity's role in defense and symbiont selection and has over 100 scientific publications in many high impact factor scientific journals.
Affiliations and expertise
Professor Emeritus, University of Oslo, NorwayRead The Cytokines of the Immune System on ScienceDirect