The Complex Interplay Between Gut-Brain, Gut-Liver, and Liver-Brain Axes
- 1st Edition - April 6, 2021
- Imprint: Academic Press
- Editor: Cristina Stasi
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 9 2 7 - 0
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 9 2 8 - 7
The Complex Interplay Between Gut–Brain, Gut–Liver, and Liver–Brain Axes provides current and wide-ranging information in the field of gastrointestinal, liver, and brain intera… Read more
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Request a sales quoteThe Complex Interplay Between Gut–Brain, Gut–Liver, and Liver–Brain Axes provides current and wide-ranging information in the field of gastrointestinal, liver, and brain interactions that can be used in resolving important clinical issues. This book is systematically split into three distinct sections. The first section introduces the pathophysiology of the gut–brain connection, including the causative effect of the interactions between the gut and brain in gastrointestinal and psychiatric/neurological disorders, and the role of serotonin and its pathways in gastrointestinal disorders. The second section examines the pathophysiology of the gut–liver connection along with the interactions between gut microbiota and liver in chronic liver diseases, with special focus on the role of serotonin and its pathways in hepatic fibrogenesis. Finally, the third section describes the pathophysiology of the liver–brain connection, including the role of gut microbiota in hepatic encephalopathy, as well as dietary and therapeutic interventions that target the gut microbiome.
- Provides current and wide-ranging knowledge in the field of gastrointestinal, liver, and brain interactions
- Resolves important clinical issues concerning gut, liver, and brain interactions
- Demonstrates advances in the understanding of the pathophysiology of gastrointestinal and liver diseases
Gastroenterology and Hepatology researchers and Gastroenterologists and Hepatologists. Immunologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Preface
- Acknowledgments
- Introduction
- Section I: Gut-brain axis
- Chapter 1. The pathophysiology of gut–brain connection
- Abstract
- 1.1 Introduction
- 1.2 The anatomical entity
- 1.3 The functional entity and the role of microbiota
- 1.4 The pathological entity
- 1.5 Conclusion
- References
- Chapter 2. The interactions between gut and brain in gastrointestinal disorders
- Abstract
- 2.1 Introduction and anatomo-physiological background
- 2.2 Clinical presentation of the disorders of the gut–brain interaction
- 2.3 Therapy of main disorders of the gut–brain axis
- References
- Chapter 3. The interactions between gut and brain in psychiatric and neurological disorders
- Abstract
- 3.1 Introduction
- 3.2 Development of gut microbiota
- 3.3 Pathways of brain–gut–microbiota interaction
- 3.4 Tryptophan metabolism
- 3.5 Endocrinologic pathway
- 3.6 Microbial neural substrates
- 3.7 Neuropsychiatric disorders affected by brain–gut interplay
- 3.8 Psychiatric disorders in gastrointestinal diseases
- 3.9 Conclusion
- References
- Chapter 4. The role of serotonin and its pathways in gastrointestinal disorders
- Abstract
- 4.1 Role of serotonin in the physiology of digestive and extradigestive systems
- 4.2 5-HT receptors, serotonin transporter, and their polymorphisms
- 4.3 Serotonin in functional gastrointestinal disorders and the brain–gut axis
- 4.4 Serotonin, psychological/psychiatric and extra-gastrointestinal comorbidities
- 4.5 Serotonin and microbiota, the brain–gut axis and the psychobiota
- 4.6 Conclusion
- References
- Section II: Gut-liver axis
- Chapter 5. The pathophysiology of gut–liver connection
- Abstract
- 5.1 Regulation of intestinal permeability
- 5.2 Role of altered intestinal permeability in the pathogenesis of NAFLD
- 5.3 Role of incretins in NAFLD
- 5.4 Alteration of bile acid pathways in NAFLD
- References
- Chapter 6. The role of gut microbiota in chronic liver diseases
- Abstract
- 6.1 Introduction
- 6.2 Metabolic liver disease
- 6.3 Primary sclerosing cholangitis
- References
- Chapter 7. Gut-liver The role of serotonin and its pathways in hepatic fibrogenesis
- Abstract
- 7.1 The state of the art
- 7.2 Serotonin synthesis and metabolism
- 7.3 Serotonin receptors
- 7.4 The natural course of chronic liver disease
- 7.5 Serotonin and liver fibrogenesis
- 7.6 Serotonin and hepatocellular carcinoma
- 7.7 Gut microbiota
- 7.8 Serotonin and gut microbiota
- 7.9 Conclusions
- Acknowledgment
- References
- Section III: Liver-brain axis
- Chapter 8. Gut–liver–brain axis in chronic liver disease with a focus on hepatic encephalopathy
- Abstract
- 8.1 Introduction
- 8.2 Gut–brain axis in health and liver disease
- 8.3 Pathogenesis of hepatic encephalopathy
- 8.4 Clinical relevance and presentation of hepatic encephalopathy
- 8.5 Treatment options
- 8.6 Recent advances
- 8.7 Outlook
- References
- Chapter 9. The gut microbiota in hepatic encephalopathy
- Abstract
- 9.1 Introduction
- 9.2 Defining hepatic encephalopathy
- 9.3 Ammonia as a driver of hepatic encephalopathy
- 9.4 Classifying HE by cause of hyperammonemia
- 9.5 The role of inflammation
- 9.6 The gut microbiome in health and disease
- 9.7 Gut dysbiosis in cirrhosis
- 9.8 Drug use in cirrhosis contributes to dysbiosis
- 9.9 How dysbiosis drives systemic inflammation and HE
- 9.10 Directly altering the gut microbiome improves outcomes in HE
- 9.11 Conclusion and future directions
- References
- Chapter 10. The gut–liver–brain axis: dietary and therapeutic interventions
- Abstract
- 10.1 Introduction
- 10.2 Routes of communication between periphery and brain
- 10.3 Gut–brain axis dysregulation in liver disease
- 10.4 Changes in brain function and behavior in liver disease
- 10.5 Therapeutics targeting gut–liver–brain axis
- 10.6 Concluding remarks
- References
- Index
- Edition: 1
- Published: April 6, 2021
- No. of pages (Paperback): 264
- No. of pages (eBook): 264
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128219270
- eBook ISBN: 9780128219287
CS
Cristina Stasi
In 2001, Cristina Stasi graduated with a degree in Medicine and Surgery at the Catholic University of the Sacred
Heart, Rome, Italy. In 2006, Dr. Stasi went on to specialize in Gastroenterology at the University of Pisa, Italy.
From 2006 to 2009, she took part in clinical research projects at the Careggi University Hospital in Florence,
Italy. At the same time, Dr. Stasi improved her knowledge in study design, management of clinical research
projects, statistics, and epidemiology. In 2013, she earned her PhD in Experimental and Clinical Medicine
from the University of Florence, Italy. Dr. Stasi has published more than 70 papers in reputed international
journals and serves as an editorial board member within international journals. She currently works at both the
MASVE Interdepartmental Hepatology Center (Department of Experimental and Clinical Medicine, University
of Florence and Center for Research and Innovation CRIA-MASVE, Careggi University Hospital, Florence,
Italy) as well as at the Epidemiology Unit (Regional Health Agency of Tuscany, Florence, Italy). Dr. Stasi has
obtained the National Scientific Qualification to work as an associate and full professor in the field of skin,
infectious, and gastrointestinal diseases in Italian universities and even to work as an associate professor in
the field of technology and methodology in medicine and nursing sciences, again in Italian universities.
Affiliations and expertise
- MASVE Interdepartmental Hepatology Center, Department of Experimental and Clinical Medicine, University of Florence and Center for Research and Innovation CRIA-MASVE, Careggi University Hospital, Florence, 50134, Italy
- Epidemiology Unit, Regional Health Agency of Tuscany, Villa La Quiete, Via Pietro Dazzi, 1, 50141 Florence, ItalyRead The Complex Interplay Between Gut-Brain, Gut-Liver, and Liver-Brain Axes on ScienceDirect