The Cell Nucleus V2

List of Contributors

Preface

Contents of Other Volumes

Introduction

Part I Chromosomes-General

Chapter 1 Mammalian Chromosomes

I. Introduction

II. DNA Content, Chromosome Number, and Chromosome Morphology

III. Sex Chromosomes

IV. Heterochromatin

V. Cytochemical Differentiation of Chromosomal Regions

VI. Somatic Cell Hybridization

VII. Chromosomes in Evolution

References

Chapter 2 The Human Cell Nucleus: Quinacrine and Other Differential Stains in the Study of Chromatin and Chromosomes

I. Perspectives on Human and Medical Cytogenetics

II. Human Chromosome Identification

III. Human Chromosome Polymorphisms

IV. Study of Chromosome Abnormalities

V. Chromosome Abnormalities in Malignancies

VI. Paternity Studies

VII. Parental Origin of Chromosome Abnormalities

VIII. Gene Mapping Using Chromosome Polymorphisms, Rearrangements,

and Somatic-Cell Hybridization

IX. Chromatin: Differentially Marked Regions on Autosomes and the Y in Interphase

X. Meiotic Chromosomes

XI. Chromosome Evolution and Banding

References

Chapter 3 Studies of Isolated Mammalian Metaphase Chromosomes

I. Introduction

II. Isolation of Metaphase Chromosomes

III. Chemical Composition of Metaphase Chromosomes

IV. Studies with Fractionated Metaphase Chromosomes

V. The Structure of Metaphase Chromosomes

VI. Conclusions

References

Chapter 4 The Kinetics of DNA Replication in Chromosomes

I. Introduction

II. The Replicon

III. The Replicon Series

IV. The Chromosome

V. Discussion

VI. Conclusions

References

Chapter 5 The Organization of Meiotic Chromosomes

I. Introduction

II. General Organization of DNA in Chromosomes

III. Special Features of Meiotic Chromosomes

IV. Relation of Chromosome Structure to Meiotic Chromosome Behavior

V. Summary and Conclusions

References

Chapter 6 Progress in Human Gene Mapping by Somatic Cell Hybridization

I. Introduction

II. Methodology and Rationale of Human Gene Mapping

III. Assignments of Genes to Human Chromosomes

IV. Regional Localization of Human Genes

V. Conclusion

References

Part II Chromosomes-Specific

Chapter 7 Chromosomes of Birds

I. Introduction

II. Phylogeny of Birds and Genome Size

III. Mitotic Chromosomes

IV. Meiotic Chromosomes

V. Heterochromatin

VI. Heteroploidy

VII. Summary

References

Chapter 8 Plant Cytogenetics

I. Physical and Chemical Constitution of Chromosomes

II. Behavior of Chromosomes in Different Tissues

III. Differentiation of Chromosome Segments

IV. Numerical and Structural Variability of Chromosome Complement—Origin and Role

V. Size and Morphology of Chromosomes in Evolution

VI. Karyotype as an Aid in Taxonomy

VII. Conclusion

References

Chapter 9 Polytene Chromosomes in Studies of Gene Expression

I. Introduction

II. DNA Content of the Chromosome Band

III. Genetic Equivalent of the Chromosome Band

IV. Relation of Puffing to Gene Activity

V. The Transcriptory Activity

VI. Release of Chromosomal RNA to the Nuclear Sap

VII. Puff RNA in the Cytoplasm

VIII. Conclusions and Perspectives

References

Chapter 10 Giant Chromosomes

I. Structural Organization of Giant Chromosomes

II. Metabolic Activities of Giant Chromosomes

III. Giant Chromosomes from the View of Genome

Organization

References

Part III Chromosomes-Pathology

Chapter 11 Clinical Cytogenetics

I. Trisomy

II. Monosomy G

III. Trisomy 18

IV. Deletion-18 Syndromes

V. B Deletion Syndromes

VI. Trisomy 13

VII. D-Deletion Syndromes

VIII. C-Group Trisomies

Chapter 12 Viruses and Chromosomes

I. Introduction

II. Types of Virus-Induced Chromosome Alterations

III. Studies on the Mechanisms of Virus-Induced Chromosomal Alteration

IV. Significance of Virus-Induced Chromosome Alterations

V. Summary

References

Part IV Mitosis and Meiosis

Chapter 13 The Mitotic Apparatus

I. Introduction

II. Fine Structure of the Mitotic Apparatus

III. Biochemistry of the Isolated Mitotic Appartus

References

Chapter 14 Genome Separation Mechanisms in Prokaryotes, Algae, and Fungi

I. Introduction

II. Prokaryotes

III. Introduction to Microtubules

IV. Algae

V. Fungi

VI. Summary

References

Author Index

Subject Index