Textbook of Pathology, 1e
- 1st Edition - May 4, 2022
- Author: Rajeswari Kathiah
- Language: English
- Hardback ISBN:9 7 8 - 8 1 - 3 1 2 - 6 2 0 7 - 8
- eBook ISBN:9 7 8 - 8 1 - 3 1 2 - 6 2 0 8 - 5
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Institutional subscription on ScienceDirect
Request a sales quoteCompetency mapping in each chapter would help to understand what is expected out of them in that particular chapter.
Mind maps will surely enhance the understanding and the memory
Two chapters in accordance to the new curriculum: Advanced Diagnostic Techniques & Clinical Pathology
Self-assessment questions in the end will assist the learners in the evaluation of their learning
Clinical case scenarios and High quality Image bank
Important points and facts being highlighted for better understanding
Mind maps will surely enhance the understanding and the memory
Two chapters in accordance to the new curriculum: Advanced Diagnostic Techniques & Clinical Pathology
Self-assessment questions in the end will assist the learners in the evaluation of their learning
Clinical case scenarios and High quality Image bank
Important points and facts being highlighted for better understanding
- Cover image
- Title page
- Table of Contents
- Copyright
- Acknowledgement
- Preface
- List of Contributors
- Competency List
- List of Tables
- List of Illustrations
- 1. Cell as a unit of health and disease
- Introduction
- Normal cell structure
- The genome
- Fundamental housekeeping mechanisms of cells
- Growth factors and receptors
- Signalling pathways (Fig. 1.16)
- Role of extracellular matrix
- Cell cycle
- Stem cells
- Self-assessment questions
- Topics for self-directed learning
- 2. Cell injury and adaptations
- Overview of cellular responses to stress
- Cellular adaptations PA2.6
- Overview of cell injury and cell death
- Causes of cell injury PA2.1
- Mechanisms of cell injury PA2.2
- Morphological changes in cell injury (Table 2.3) PA2.2
- Ischaemia–reperfusion injury
- Apoptosis PA2.4, PA2.7
- Autophagy
- Autolysis PA2.4
- Intracellular accumulations PA2.3
- Pathological calcification PA2.5
- Cellular ageing PA2.7
- Self-assessment questions
- Topics for self-directed learning
- 3. Inflammation, healing and repair
- Overview of inflammation
- Acute inflammation PA4.1
- Chronic inflammation PA4.3
- Systemic effects of inflammation (Fig. 3.32)
- Healing and repair PA5.1
- Self-assessment questions
- Answer key
- Topics for self-directed learning
- 4. Haemodynamic disorders
- Introduction
- Hyperaemia and congestion PA6.2
- Haemorrhage PA6.2
- Oedema and effusions PA6.1
- Haemostasis PA6.4
- Thrombosis PA6.4
- Embolism PA6.5
- Infarction PA6.6
- Shock PA6.3
- Self-assessment questions
- Topics for self-directed learning
- 5. Genetic disorders
- Introduction
- Mendelian disorders PA11.1
- Autosomal disorders with defects in structural proteins
- Autosomal disorders with defective receptor proteins
- Autosomal disorders with enzyme defects PA11.3
- Non-Mendelian disorders
- Complex multigenic disorders/multifactorial disorders
- Chromosomal disorders
- Molecular genetic diagnosis
- Self-assessment questions
- Answer key
- Topics for self-directed learning
- 6. Immune disorders
- The immune system
- The normal immune response PA9.1
- Hypersensitivity reactions PA9.2
- Autoimmune disorders PA9.4, PA9.5 AND PA9.7
- Immunodeficiency disorders
- Transplant rejection reactions PA9.3
- Amyloidosis PA3.1
- Self-assessment questions
- Topics for self-directed learning
- 7. Neoplasia
- Overview PA7.1
- Epidemiology and aetiology of cancer
- Molecular basis of malignancies PA7.2
- Carcinogenic agents and carcinogenesis PA7.3
- Clinical presentation of tumours
- Paraneoplastic syndromes (Table 7.19) PA7.4
- Laboratory diagnosis of cancer
- Molecular profiling of tumours – precision oncology
- Self-assessment questions
- Topics for self-directed learning
- 8. Infectious diseases
- Introduction
- Common bacterial infections
- Common viral infections
- Common fungal infections
- Parasitic infections
- Emerging infectious diseases
- Special techniques for diagnosis of infectious diseases
- Self-assessment questions
- Self-directed learning
- 9. Environmental and nutritional disorders
- Introduction
- Environmental effects on global disease burden
- Environmental pollution
- Effects of tobacco PA12.1
- Effects of alcohol PA12.1
- Injury by physical agents
- Nutritional diseases
- Self-assessment questions
- Topics for self-directed learning
- 10. Disorders of infancy and childhood
- Introduction
- Congenital anomalies
- Diseases associated with prematurity
- Fetal hydrops
- Inborn errors of metabolism
- Other genetic disorders
- Sudden infant death syndrome
- Tumours and tumour-like lesions of infancy and childhood PA11.2
- Self-assessment questions
- 11. Basic diagnostic cytology and clinical pathology
- I. Basic diagnostic cytology
- Introduction
- Role of diagnostic cytology PA8.1
- Staining methods in cytology
- Types of diagnostic cytology
- II. Clinical pathology
- Urine analysis PA23.1
- Examination of body fluids PA23.2
- Organ function tests PA23.3
- Semen analysis
- Self-assessment questions
- Answers
- Topics for self-directed learning
- 12. Advanced diagnostic techniques
- Introduction
- Immunohistochemistry
- Immunofluorescence
- Frozen section
- Flow cytometry
- Electron microscopy
- Polarizing microscopy
- Fluorescence in situ hybridization
- Electrophoresis
- Blotting techniques
- Polymerase chain reaction
- Next-generation sequencing
- Multiplex ligation-dependent probe amplification
- Linkage analysis
- Tissue microarray
- Self-assessment questions
- Topics for self-directed learning
- 13. Blood vessels
- Overview of vascular system
- Vessel wall response to injury
- Hypertensive vascular disease
- Arteriosclerosis PA27.1
- Atherosclerosis PA27.1
- Aneurysms and dissection PA27.2
- Vasculitis
- Vascular tumours
- Self-assessment questions
- Answer key
- Self-directed learning topics
- 14. The heart
- Introduction
- Overview of cardiac structure and physiology
- Overview of cardiac pathophysiology
- Heart failure PA 27.3
- Congenital heart diseases
- Ischaemic heart disease PA27.5
- Arrhythmias
- Sudden cardiac death
- Hypertensive heart disease
- Syphilitic heart disease PA27.10
- Diseases of the valves
- Cardiomyopathies PA27.9
- Pericardial diseases PA27.7
- Cardiac tumours
- Self-assessment questions
- Answer key
- Topics for self-directed reading
- 15. Red cell disorders
- Introduction and basic haematology
- Anaemias PA13.3
- Polycythaemia
- Self-assessment questions
- Key
- Topics for self-directed learning
- 16. Disorders of white blood cells, lymph nodes, spleen and thymus
- Introduction
- I. WBCs and lymphnodes
- Non-neoplastic disorders of WBCs
- Non-neoplastic disorders of lymph nodes
- Neoplastic proliferations of WBCs
- II. Spleen
- III. Thymus
- Self-assessment questions
- Answer key
- Self-directed learning topics
- 17. Bleeding disorders
- Review of haemostasis PA21.1
- Bleeding disorders
- Disorders due to vessel wall abnormality PA21.2
- Disorders due to platelet abnormality
- Bleeding disorders due to defects in clotting factors
- Disseminated intravascular coagulation (PA21.4)
- Vitamin K deficiency (PA21.5)
- Platelet versus clotting disorders (Table 17.8) (PA21.3)
- Approach to a patient with bleeding disorder (Fig. 17.17)
- Self-assessment questions
- Answer key
- Topics for self-directed learning
- 18. Transfusion medicine
- Introduction to transfusion medicine
- Blood group systems (Table 18.1) PA22.1
- Pretransfusion compatibility tests PA22.2
- Blood components (cellular and plasma) and plasma derivatives (fractions) PA22.4
- Transfusion reactions PA22.6
- Nonimmune reactions
- Transfusion-transmissible infections PA22.5
- Autologous blood donation PA22.7
- Self-assessment questions
- Self-directed learning
- 19. The lungs
- Introduction
- Atelectasis
- Pulmonary oedema
- Acute lung injury and acute respiratory distress syndrome
- Obstructive and restrictive lung diseases (Table 19.3)
- Obstructive pulmonary diseases PA26.3
- Restrictive lung diseases
- Diseases of pulmonary blood vessels
- Tuberculosis, TB PA26.4
- Pulmonary infections
- Tumours PA26.6
- Lung transplantation
- Pleura
- Self-assessment questions
- Answer key
- Topics for self-directed learning
- 20. Head and neck
- I. Diseases of the oral cavity
- II. Diseases of the upper airways
- III. Diseases of the neck
- IV. Diseases of the salivary glands
- Self-assessment questions
- Answer key
- Topics for self-directed learning
- 21. The gastrointestinal tract
- Anatomy and histology
- Congenital anomalies
- Oesophagus
- Stomach
- Small intestine and colon
- Self-assessment questions
- Answer key
- Topics for self-directed learning
- 22. Liver and gallbladder
- Introduction
- Anatomy, histology and functions of the liver
- Mechanisms of injury and repair
- Liver failure PA25.2
- Hepatitis PA25.3
- Fatty liver disease
- Alcoholic liver disease PA25.4
- Inherited liver diseases
- Cholestatic diseases
- Autoimmune cholangiopathies
- Nodules and tumours of the liver
- Gallbladder
- Self-assessment questions
- Answers
- Topics for self-directed learning
- 23. The pancreas
- Anatomy and histology of pancreas
- Congenital anomalies
- Pancreatitis
- Non-neoplastic cysts of the pancreas
- Pancreatic neoplasms
- Self-assessment
- Key
- Topics for self-directed learning
- 24. The kidney
- Introduction and basics
- Clinical manifestations of renal disease
- Renal failure PA28.2
- Glomerular diseases PA28.5
- Tubular and interstitial diseases
- Vascular diseases PA28.11
- Cystic diseases of the kidney PA28.12
- Obstructive uropathy (urinary tract obstruction) PA28.13
- Neoplasms of the kidney PA28.14
- Self-assessment questions
- Answers
- Topics for self-directed learning
- 25. The lower urinary tract and male genital system
- I. Lower urinary tract
- Development, anatomy and histology
- Congenital anomalies of the lower urinary tract
- Diseases of the ureters
- Diseases of the urinary bladder
- Diseases of the urethra
- II. Male genital system
- Development, anatomy and histology of the male genital system
- Congenital anomalies
- Diseases of the penis
- Diseases of the testis and epididymis
- Prostate
- Self-assessment questions
- Answer key
- Topics for self-directed learning
- 26. The female genital tract
- Introduction
- Diseases of the vulva
- Diseases of the vagina
- Diseases of the cervix
- Endometrium and body of the uterus
- Fallopian tubes
- Ovaries
- Gestational trophoblastic diseases PA30.5
- Self-assessment questions
- Answers
- Tasks for self-directed learning
- 27. The breast
- Introduction
- Clinical presentation of breast diseases
- Investigations in breast diseases
- Developmental disorders
- Inflammatory lesions
- Benign epithelial lesions PA31.1
- Stromal tumours PA31.1
- Gynaecomastia PA 31.4
- Carcinoma of the breast PA 31.2
- Male breast cancer
- Other malignant tumours of the breast
- Laboratory approach to a case of breast carcinoma
- Self-assessment questions
- Answer key
- Topics for self-directed learning
- 28. The endocrine system
- Introduction
- I. The thyroid gland
- II. The parathyroid gland
- III. The endocrine pancreas
- IV. The adrenal gland
- Self-assessment questions
- Answer key
- Topics for self-directed learning
- 29. The skin
- Introduction
- Inflammatory dermatoses
- Blistering (Bullous) diseases
- Infections
- Disorders of melanocytes
- Benign epithelial tumours
- Premalignant epidermal tumours
- Malignant epidermal tumours
- Adnexal tumours
- Dermal tumours
- Tumours of migrants to skin
- Self-assessment questions
- Answers
- Tasks for self-directed learning
- 30. Bones, joints, soft tissue tumours, skeletal muscle and peripheral nervous system
- I. Bones
- Structure and functions of bone
- Developmental disorders of bone and cartilage
- Metabolic disorders of bone
- Osteomyelitis PA33.1
- Tumour and tumour-like lesions PA33.2
- II. Joints
- Osteoarthritis
- Rheumatoid arthritis PA33.5
- Seronegative spondyloarthropathies
- Infectious arthritis
- Crystal-induced arthritis
- III. Soft tissues
- Tumours PA33.3
- Tumours of adipose tissue
- Fibrous tumours
- Smooth muscle tumours
- Tumours of uncertain origin
- Undifferentiated pleomorphic sarcoma
- IV. Skeletal muscles
- Inherited diseases
- Skeletal muscle tumours
- Tumours
- V. Peripheral nerve sheath tumours
- Tumours
- Self-assessment questions
- Answer key
- Tasks for self-directed learning
- 31. Central nervous system and eye
- Anatomy and histology
- Reaction of cells of central nervous system to injury
- Cerebrovascular disease
- Infections
- Prion diseases
- Demyelinating diseases
- Neurodegenerative diseases
- Acquired metabolic diseases
- Tumours of the brain PA35.2
- Eye
- Self-assessment questions
- Answer key
- Topics for self-directed learning
- Appendix-Mind Maps
- Index
- No. of pages: 910
- Language: English
- Edition: 1
- Published: May 4, 2022
- Imprint: Elsevier India
- Hardback ISBN: 9788131262078
- eBook ISBN: 9788131262085