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Textbook of Nephro-Endocrinology

The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidney… Read more

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Description

The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism.

Key features

  • Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems
  • Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work
  • Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field

Readership

Researchers and clinicians in nephrology and endocrinology

Table of contents

Part 1: The Kidney as an Endocrine Organ

Section 1: Erythropoietin

1.Erythropoientin: An Historical Overview of Physiology, Molecular Biology
And Gene Regulation
David R. Mole, Peter J. Ratcliffe


2.Erythropoiesis: The Role of Erythropoietin and Iron
Herbert Lin


3.Extra-Hematopoietic Action of Erythropoietin
Zheqing Cai, Gregg Semenza


4.Development of Recombinant Erythropoietin and Erythropoietin Analogues
Iain Macdougall


5.Erythropoietin Disease States & Resistance
Ajay K. Singh, Tejas Patel, Shona Pendse, Sairam Keithi-Reddy
Section 2: Vitamin D, PTH and Novel Regulators of Phosphate


6.Vitamin D and the Kidney: Introduction and Historical Perspective
Ajay K. Singh, Tejas Patel


7. Vitamin D: Molecular Biology and Gene Regulation
Adriana Dusso, Alex J. Brown


8. Molecular Biology of Parathyroid Hormone
Peter A. Friedman


9.Endocrine Regulation of Phosphate Homeostasis
Harald Jüppner
Section 3: Renin-angiotensin

10.Introduction and Historical Overview
Joel Menard


11.Molecular Biology of Renin and Regulation of Its Gene
Timothy L. Reudelhuber, Daniel F. Catanzaro


12. Physiology and Regulation of the RAAS System
Robert Carey, Shetal H. Padia


13. The Renin Angiotensin Aldosterone System and the Kidney
George Bakris, Benjamin Ko


14. The Renin Angiotensin and the Heart
Carlos Ferrario, Aaron Trask


15. The Renin-Angrotensin blockade: Therapeutic Agents
Domenic Sica
Part 2: The Kidney as a Hormonal target
Section 4: Anti-diuretic Hormone

16. Vasopressin in the Kidney: Historical Aspects
Jeffrey Sands, Lynn E. Schlanger


17. Molecular Biology and Gene Regulation
Carolyn Ecelbarger, Swasti Tiwari


18. Vasopressin Antagonists in Physiology and Disease
Tomas Berl, Robert W. Schrier


19. Diabetes Insipidus and SIADH
J Carlos Ayus, Michael Moritz

Section 5: The Atrial Natriuretic Peptides


20. ANP, BNP and CNP Physiology and Pharmacology of the Cardiorenal Axis
John C Burnett, Jr., Candace Lee

Section 6: Aldosterone

21.Introduction and Historical Overview
John Coghlan, James Tait


22.Aldosterone Receptors and Their Renal Effects: Molecular Biology
And Gene Regulation
Celso Gomez-Sanchez, Elise P. Gomez-Sanchez, Mario Galigniana

23. Aldosterone and Its Cardiovascular Effects
Gail K Adler, Rajesh Garg


24. Aldosterone Regulation
William Rainey, Wendy B. Bollag, Carlos M. Isales
Section 7: Endocrine Disorders in Renal Failure


25. Insulin resistance
Donald Simonson


26. Growth hormone
John Mahan


27.Sexual Dysfunction in Men and Women with Chronic Kidney Disease
Biff F. Palmer


28.Thyroid Status in Chronic Renal Failure Patients
Victoria Lim, Manish Suneja


29.Metabolic Acidosis of Chronic Kidney Disease
Jeffrey A. Kraut, Glenn T. Nagami


30.Pregnancy and the Kidney
Ananth Karumanchi, Chun Lam

Review quotes

"This well-written, relatively concise, and current book will find a home on the shelves of many nephrologists and endocrinologists. Because it is so readable, it should be useful for students, experts, and those in between. I know I will consult my copy on a frequent basis - an unusual event in this era of online material."—N Engl J Med, 2009

"All in all, this is a solid book that provides substantial up-todate information on endocrine aspects of the kidney. I will be glad to pull it down from my shelf rather than one of the true heavyweights to which I would previously have gone for this kind of reading."—Kidney International, 2009

"Written by multidisciplinary experts from several countries, this book is divided into 2 parts and 7 sections. A very useful volume. Each chapter is richly referenced."—Pediatric Endocrinology Reviews

Product details

About the editors

AS

Ajay K. Singh

Dr. Singh has led groundbreaking studies in anemia of kidney disease, including the CHOIR study, which was published in the New England Journal of Medicine, and well as being a member of the steering committees for the TREAT and DRIVE studies. More recently, he has taken on the role of leading the ASCEND Clinical development program - a phase 3 program for the development of a novel propyl hydroxylase inhibitor Daprodustat. The trial is aiming to recruit 7500 patients in over countries. He currently leads the office of Postgraduate Medical Education at the Brigham and Women's Hospital, and in this capacity leads several HMS CME courses. He is the author of over 160 original contributions and review articles, as well as author/editor of 11 books in internal medicine and nephrology. Dr. Singh is a Fellow of the Royal College of Physicians in London, and has an MBA from Boston University.
Affiliations and expertise
Nephrologist, Renal Division, Department of Medicine, Brigham and Women’s Hospital, Senior Associate Dean for Postgraduate Medical Education, Harvard Medical School, Boston, MA, USA

GW

Gordon H. Williams

Dr. Gordon H. Williams is an endocrinologist in Boston, Massachusetts and is affiliated with Brigham and Women's Hospital. He received his medical degree from Harvard Medical School and has been in practice for more than 30 years. He has published ~300 papers, is a well-respected and well-known expert, speaker and leader in the field of endocrinology.
Affiliations and expertise
Director, Center for Clinical Investigation, Brigham and Women's Hospital, Professor of Medicine, Harvard Medical School, Cambridge, MA, USA

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